Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of the mixed disease of the connective tissue (MCTD) in male patient occupationally exposed to PVC and other toxic agents is presented. Clinical symptoms consisted of the typical signs of SLE, rheumatoid arthritis and lupoid hepatitis. MCTD diagnosis was confirmed serologically by the presence of autoantibodies anti-RNP. Prednisone administered in the daily dose of 60 mg produced remission.
Pol Tyg Lek
PMID:[Mixed connective tissue disease in a male patient chronically exposed to toxic chemicals]. 830 26

The subject of analysis were data concerning the 101 pregnancies in 43 patients with systemic lupus erythematodes observed in years 1965-1990. The evaluation proved that pregnancy does not deteriorate the course of lupus nephritis that is in the remission before the conception. In lupus patients the risk of fetal loss and stillbirth is high, especially in the presence of anticardiolipin antibodies. The course of active lupus occurring during pregnancy is frequently severe and its effect on the pregnancy is very harmful.
Ginekol Pol 1995 Jun
PMID:[Lupus pregnancy, its effect on the course of lupus nephritis and the evaluation of fetal loss frequency]. 852 33

106 women was screened for a lupus anticoagulant. Activated partial thromboplastin time, tissue thromboplastin inhibition test and euglobulin lysis time was performed. Ten of 61 women (16%) with spontaneous multiple abortions, foetal death, intrauterine growth retardation (IUGR) and gestosis had one or two pathological results of tests while no one of the 41 women which had no pregnancy complication. Significance of difference between this two groups was verified by Fischer exact test (P less than 0.05).
Ginekol Pol 1995 Feb
PMID:[Hemostatic disturbances in women with unexplained fetal loss]. 857 82

Here is presented a case of woman treated by immunosuppressive preparations because of systemic lupus erythematosus with ski manifestations as tubercles and ulcerations on skin of trunk and extremities. On the basis of histological examination of tubercle skin specimens and mycological examinations of material obtained from skin ulcerations cryptococcosis was diagnosed. Disease was limited to skin that was an entry of infection. Patient was treated by Amphotericin B administered intravenously and Flucitosine per os. Amphotericin B was also applied topically. The results of cultures became gradually negative, up to total disappearance of fungus cells in direct specimens, prepared from examined material. After treatment continuing for 5 months only discoloured scars were observed on sick skin.
Pneumonol Pol
PMID:[A case of skin cryptococcosis in systemic lupus erythematosus]. 861 77

Vascular diseases of CNS are usually a result of certain risk factors. In a number of cases vascular diseases are caused by inflammatory process within arteries. Establishing the intrathecal synthesis of immunoglobulins is an important indicator of the inflammatory process in the CNS. 16 patients with multifocal vascular lesions in neuroimaging examinations (MRI or CT), were analysed for the frequency of occurrence of inflammatory process within the CNS. The presence of intrathecal synthesis of IgG was established by mathematical formulas and presence oligoclonal IgG bands. In some patients presence of oligoclonal IgG bands was found, and regarded responsible for stroke. In this group the patients were younger, and mainly without other risk factors for vascular diseases. In the majority they were patients with systemic inflammatory process (e.g. SLE). The establishing of inflammatory process within the CNS sometimes has therapeutic implications.
Neurol Neurochir Pol
PMID:[Detection of oligoclonal immunoglobulin G in the cerebrospinal fluid of patients with multifocal vascular lesions of the CNS]. 875 49

The aim of the investigation was microalbuminuria evaluation as an early symptom of renal involvement in systemic lupus erythematosus (SLE). Thirty patients aged 18 to 66 years (mean: 39,4 years) with mean duration of SLE of 6,3 years (range: 0,5 to 22 years) were examined. All of them fulfilled the preliminary criteria of the American Rheumatism Association for the classification of SLE. During the study none of patients had clinical or laboratory symptoms of nephropathy, hypertension, diabetes mellitus and heart failure. Microalbuminuria was measured by immunoturbidimetric method and the urine microalbumin concentration was expressed as the ratio microalbumin-creatinine concentration in 24 hour urine [equation: see text] Ratio I was 3,36 (+/- 2,76) in patients suffering from SLE comparing to I = 1,35 (+/- 0.89) in normal controls (p < 0.001). There was no correlation between increasing microalbuminuria and patients age and duration of disease. There was also no correlation between microalbuminuria and erythrocyte sedimentation rate or immunological activity parameters (i.e. antinuclear antibodies, anti dsDNA antibodies, levels of C3 and C4 components of complement).
Pol Arch Med Wewn 1996 Aug
PMID:[Microalbuminuria in patients with systemic lupus erythematosus]. 912

Antiphospholipid-protein syndrome (APS) comprises venous and arterial thrombosis, spontaneous abortion and thrombocytopenia in patients with antiphospholipid-protein antibodies (APA). Such antibodies are detected by immunoenzymatic (ELISA) methods (e.g. anticardiolipin antibodies-ACL) or coagulation assays (lupus anticoagulant-LA). APS in patients showing other symptoms of autoimmune disease is called secondary antiphospholipid-protein syndrome. The aim of the study was to find relation between history of thrombosis and APA in a group of patients with lupus erythematosus and lupus-like disease. Lupus anticoagulant was detected by a three step procedure using phospholipid dependent clotting assays and anticardiolipin antibodies were measured by ELISA. We studied 95 subjects (91 women, 4 men) suffering from lupus erythematosus (67 patients) and lupus-like-disease (28 patients). Lupus anticoagulant was found in 26, anticardiolipin antibodies IgG in 34 and IgM in 27 subjects. In a retrospective study 40 thrombotic events were detected in 36 patients; deep vein thrombosis in 19, pulmonary embolism in 7, ischaemic CNS events in 13 and myocardial infarction in one. Thrombosis was present more often in subjects with LA (61%) and ACL IgG (52%) than in subjects without these antibodies (24%) (p = 0.004 and 0.015, respectively). ACL IgM antibodies were not related to thrombotic episodes. The ACL IgG antibodies and LA are helpful in identifying subjects at risk factors of venous and arterial thrombosis among patients suffering from lupus erythematosus and lupus-like disease.
Pol Merkur Lekarski 1996 Nov
PMID:[Prevalence of thrombosis in secondary antiphospholipid-protein syndrome]. 927 2

This is a case report of a 34 years old man with Evans syndrome associated with antiphospholipid-protein antibodies. They include lupus anticoagulant and antibodies against cardiolipin, prothrombin and beta 2-glycoprotein I, detected by ELISA. No thrombotic events were observed. The presence of several antibodies directed against surface cell membrane structures in Evans syndrome suggests a common pathogenetic mechanism.
Pol Merkur Lekarski 1996 Nov
PMID:[Evan's syndrome with antiphospholipid-protein antibodies]. 927 14

Lupus anticoagulant (LA) prolongs clotting times in vitro, but in vivo leads to an increased risk of thromboembolic complications. LA is detected in many patients with lupus erythematosus but also in subjects without any autoimmune disease (primary antiphospholipid syndrome). We determined LA in 133 patients, mostly with lupus erythematosus and other autoimmune diseases. Three screening and two confirmatory tests based on different mechanisms of clotting system activation were used. LA was found in 34 patients. DRVVT was the most useful test in detecting LA while kaolin clotting time was the least sensitive. Anticardiolipin antibodies (ACL) of IgG class were found in 41 patients studied (31%). They were most often detected in patient positive for LA (64%). ACL IgM were not associated with prolonged clotting times. Laboratory diagnosis of antiphospholipid syndrome is easy when the presence of LA is confirmed by two independent tests and in addition ACL would be detected. In other cases, when only single tests are positive, it is suggested to repeat diagnostic procedure at least once.
Pol Merkur Lekarski 1996 Nov
PMID:[Laboratory diagnosis of lupus anticoagulant]. 927 19

Various hemostatic abnormalities that can be met in the course of apparently unrelated diseases are caused by antiphospholipid antibodies (APA). Nearly on half of the population with antibodies detectable in serum suffer from systemic lupus erythematosus (SLE) or the disease will be diagnosed in the future. The supposition considering that APA do not bind phospholipids directly becomes popular recently. They bind serum beta 2-Glycoprotein. The APA-beta 2 GIP complexes speed up prothrombin activation and make beta 2 GIP less available for serum C- and S-protein transformation. APA are a heterogenous population of antibodies. Postinfectious APA differ from those found in autoimmune diseases. Thrombotic events caused by APA are treated according to general principles. Steroid therapy is essential in treatment programme of SLE with APA. In severe cases it is supplemented by intravenous cyclophosphamide. Plasmapheresis and intravenous immunoglobulins are of limited usefulness. In severe resistant thrombocytopenia one can try to introduce Danazol carefully.
Pol Tyg Lek 1996 May
PMID:[Antiphospholipid antibody syndrome in systemic lupus erythematosus]. 928 18


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>