Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunoglobulin G (IgG) antibodies reactive with intracellular components of transformed cells were detected in 26/35 sera from patients with melanoma using immunofluorescence and/or Western blotting. By extracting cellular proteins with either sodium dodecyl sulphate or moderate concentrations of salt (400 mM NaCl), the protein antigens were partially characterized by immunoblotting procedures. Although considerable heterogeneity in the molecular weights of the protein antigens was observed, two common groups were delineated. The anti-Pol antibodies reacted with 30 kd cytoplasmic protein and the anti-Ca antibodies recognized acidic high molecular weight (75-95 kd) proteins. These antigens were detected in all transformed cell lines tested, but were not restricted to them. Anti-Ca and anti-Pol antibodies were not found in sera from patients with other solid tumors or in systemic lupus erythematosus.
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PMID:Detection of immunoglobulin G antibodies in melanoma sera reactive with intracellular proteins. 333 62

A solid support radioimmunoassay has been developed to detect immunoglobulin specific circulating antibodies to polyuridylic acid (Pol U), single-stranded RNA (ss RNA), and single-stranded DNA (ss DNA) in scleroderma and other connective tissue diseases. The assay system uses flex-vinyl microtiter plates on which bovine methyl albumin, the respective polynucleotide, a 1:80 dilution of patient serum, and tritiated high affinity anti-IgG, -IgA, or -IgM are layered. The individual wells containing the sandwich assay are then counted for the presence of labeled immunoglobulins and the results are reported in microgram/ml. Of the 30 scleroderma patients tested, only patients with diffuse systemic scleroderma had antibody levels reactive to Poly U > 4.0 microgram/ml and to ss RNA < 3.0 microgram/ml. Patients with linear scleroderma or morphea had antibody levels to Poly U < 3.0 microgram/ml and very little antibody to ss DNA or ss RNA in their sera. Partial cross reactivity to Poly U was found only in SLE patients with high levels of Ab to ss DNA. Insignificant levels of Poly U antibody were found in patients with other connective tissue diseases and in normal controls. High levels of serum antibody in patients which reacted with Poly U suggest active diffuse systemic scleroderma.
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PMID:Elevated levels of antibodies to polyuridylic acid detected and quantitated in systemic scleroderma patients by solid phase radioimmunoassay. 615 54

Using as target cells chicken erythrocytes labelled with chromium 51Cr the cytotoxic activity (spontaneous and induced with PHA and Con A mitogens) of peripheral blood lymphocytes was studied in patients with multiple sclerosis. The control group comprised healthy subjects, patients with systemic lupus erythematosus and other central nervous system diseases. No changes were observed in the cytotoxic activity of lymphocytes of patients with multiple sclerosis without respect to the course and a duration of the disease process. On the other hand, in patients with SLE a decrease of cytotoxic activity was observed in vitro, both spontaneous activity (p less than 0.01) and mitogen-induced (p less than 0.05) as compared with other group of patients.
Neurol Neurochir Pol
PMID:[In vitro cytotoxic activity of peripheral blood lymphocytes in patients with multiple sclerosis. Preliminary report]. 666 8

A case of SLE in female 43 years old is presented. The patient was hospitalized with diagnosis of pneumonia. The correct diagnosis was made after LE-cell and antinuclear antibodies in blood serum were found. After the treatment with small prednisone doses the long years remission was given. In discussion the diagnosis difficulties and basis diagnosis are presented.
Pneumonol Alergol Pol 1994
PMID:[Diagnostic difficulties in systemic lupus erythematosus]. 752 26

Systemic lupus erythematosus (SLE) remains a disease of unknown origin, characterized by major alterations of both the cellular and the humoral arms of immunity. Hematological changes, including anaemia, leucopenia and thrombocytopenia, occur in more than one half of patients with this disease. Anaemia is the most common hematological abnormality seen in SLE. Its possible causes are anaemia of chronic disease (ACD), auto-immune haemolytic anaemia and hypoplastic anaemia. Leucopenia affects both granulocytic and lymphocytic lines and may be caused by autoantibodies. The influence of drugs, hypersplenism and marrow suppression are also possible. Thrombocytopenia occurs frequently and is almost invariably autoimmune. Patients with SLE are at increased risk of thrombosis. Haematological abnormalities in patients with this disease require careful long-term monitoring and prompt therapeutic intervention.
Acta Haematol Pol 1995
PMID:[Hematologic problems in systemic lupus erythematosus]. 765 19

We presented the coexistence of the severe aortic insufficiency and the systemic lupus erythematosus with antiphospholipid syndrome in 33-years old woman. She was qualified for the operation of the prosthesis aortic valve replacement after she was treated with steroids. During the operation, the heart infarct of the inferior wall had been observed, but finally in the postoperation period the heart efficiency improvement was observed. We have discussed same theories and clinical experiences of lupus erythematosus with antiphospholipid syndrome and clinical sequels.
Pol Arch Med Wewn 1994 Dec
PMID:[Coexistence of severe aortic insufficiency and systemic lupus erythematosis with antiphospholipid syndrome--case report]. 771 57

DNA metabolism in lymphocytes was evaluated in patients suffering from the nephrotic syndrome decompensation, basing on measurement of endonucleases (DNases) activity in these cells. The examination involved 17 patients, aged 27.7 +/- 7.11 with clinical and biochemical active disease, all with the nephrotic syndrome decompensation and erythrocytes in urine. A significant rise in the enzyme activity was observed in T and B lymphocytes (p < 0.001) in all the patients, with a distinct 3-fold increase in enzyme activity in B lymphocytes, when compared with the other cell populations. To elucidate the nature of the observed changes in DNases activity in systemic lupus erythematosus, nucleus proteins of the cells were separated electrophoretically in acrylamide gradient with immobilized DNA. Degradation processes in nucleic acids were considerably more efficient than the DNA synthesis in B lymphocytes of these cells. A smaller increase in the enzyme activity in T cells than in B lymphocytes results exclusively from more intense catabolism of nucleic acids not parallel to the intensified DNA synthesis in these cells.
Pol Arch Med Wewn 1994
PMID:[DNA metabolism in lymphocytes of patients with lupus nephropathy]. 773

Lupus anticoagulant and anticardiolipin antibodies belong to a heterogeneous family of antiphospholipid antibodies, directed probably against complexes composed of protein and negatively charged phospholipids. The antiphospholipid syndrome consists in the association of antiphospholipid antibodies and both venous and arterial occlusive events. The mechanism by which the antiphospholipid antibodies could induce thrombosis remains unclear.
Acta Haematol Pol 1994
PMID:[Diagnostic antiphospholipid antibodies and their clinical significance]. 799 77

In a 45 years woman with advanced nephrotic syndrome in the course of SLE IgM nephropathy, transient renal failure made the continuation of the conventional steroid therapy impossible. Applied as a saving life therapy, plasmapheresis followed by i.v. pulses of cyclophosphamide, caused resolution of lupus nephritis. Since the withdrawal of cyclophosphamide, the patient has been observed for 18 month, showing no evidence of recurrence of lupus nephritis.
Pol Arch Med Wewn 1994 Mar
PMID:[Lupus nephritis with nephrotic syndrome successfully treated with plasmapheresis and cyclophosphamide]. 802 31

Renal biopsies collected from 18 patients with the symptoms of nephropathy accompanying systemic lupus erythematosus-diagnosed and clinically confirmed according to the accepted criteria-were examined histologically. Morphological examinations revealed mesangiocapillary glomerular nephritis in 11 patients, mesangial proliferative glomerular nephritis in 6 patients, and focal proliferative glomerular nephritis in 1 patients. Morphological examination was widened by calculation of process activity (AI) and chronicity (CI). Despite diagnosed diffuse glomerular nephritis, the prognosis was rather good in the majority of patients. To the group of "increased risk" only 5 patients were classified. No correlation between clinical symptoms, renal involvement and AI and CI values was found.
Pol Tyg Lek
PMID:[Morphologic description of kidney in systemic lupus erythematosus with particular attention to features indicating active or chronic process]. 817 Aug 12


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