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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cardiac manifestations of antiphospholipid antibody syndrome (APLS) comprise a major complication. Herein we report our surgical treatment of aortic regurgitation in a patient with APLS. A 61-year-old woman was referred to our hospital with symptoms of congestive heart failure. Systemic lupus erythematosus had been diagnosed at the age of 36, and immunosuppressive therapy has been continuously performed. APLS was also diagnosed at the age of 55, after which cardiomegaly was noted on chest radiographs and aortic regurgitation was evident on echocardiography. Although immunosuppressive therapy had been continued, cardiac symptoms began to develop. With a presumed diagnosis of valvular disease associated with autoimmune disease, the aortic valve was replaced with a bioprosthesis. Noninfective endocarditis was confirmed in the excised specimen and was likely involved in APLS. The patient was discharged on postoperative day 26 without complications.
Gen Thorac Cardiovasc Surg 2007 Jul
PMID:Aortic valve replacement for aortic regurgitation in a patient with antiphospholipid antibody syndrome. 1767 59

Systemic lupus erythematosus (SLE) is a disease of unknown origin that can affect organs and cause severe damage. Lupus is diagnosed through biopsies and laboratory examinations; however, certain clinical characteristics and the presence of lesions can help with early diagnosis and improve the disease prognosis. SLE patients generally receive immunosuppressants that may cause systemic implications---such as suture dehiscence, increased risk of infection, and delayed healing--that deserve specific attention during dental treatment. This article presents a case of a SLE patient with oral manifestations: ulcerative lesions in the mouth and development of lupus nephritis. This article seeks to emphasize the importance of recognizing the lesions related to SLE, which may help the dentist to establish an early diagnosis.
Gen Dent
PMID:Oral manifestation of systemic lupus erythematosus: lupus nephritis--report of a case. 1825 58

Mucosa-associated lymphoid tissue (MALT) lymphoma arising from the thymus is extremely rare. We present a case of a 23-year-old woman with systemic lupus erythematosus (SLE) who was diagnosed with thymic MALT lymphoma. In 2004, she was diagnosed with a mediastinal tumor on chest radiography during medical follow up for SLE. An anterior mediastinal tumor with multilobular cysts was identified by computerized tomography and magnetic resonance imaging. A thymic malignancy was suspected and an extended thymectomy was performed. After histological and immunohistochemical examinations, the thymic tumor was diagnosed as a MALT lymphoma. There was no recurrence in the 2-year follow-up during which time there was no further treatment.
Gen Thorac Cardiovasc Surg 2008 Jun
PMID:Mucosa-associated lymphoid tissue lymphoma in the thymus of a patient with systemic lupus erythematosus. 1856 24

Catatonia may be encountered in psychiatric disorders, but also in general medical conditions. Cases of catatonia associated with systemic lupus erythematosus (SLE) are rare. Several articles have described this symptomatic association, as well as its management, using electroconvulsive therapy, plasma exchange or benzodiazepines. We report three cases here of patients who presented with catatonia during a lupus relapse, in whom treatment with lorazepam improved the catatonic symptomatology, thus allowing the associated condition to be treated. We touch on several points about the diagnosis, etiology and treatment of catatonia, when it is associated with SLE.
Gen Hosp Psychiatry
PMID:Catatonia and systemic lupus erythematosus: a clinical study of three cases. 1913 15

Performances across a wide variety of animal species share a similar pattern of development. Performance starts out low, over time increases to a peak, and then declines with old age. The increase of performance in early life is due to growth, adaptation, and learning. The author examined changes in running performance in 14 elite greyhound (Canis lupus familiaris) runners. The time to peak performance from initiation of a professional career took up 9.1% of a typical dog's lifespan. This amount of time devoted to skill development relative to species lifespan is similar to that of elite human track runners. Even with controll for changes in size (weight in kilograms), dogs' skill development showed marked improvement with increasing race experience. The author discusses the benefit of future research on motor-skill acquisition in nonhuman athletes.
J Gen Psychol 2009 Jul
PMID:Exceptional running skill in dogs requires extensive experience. 1965 May 25

A 45-year-old woman with antiphospholipid antibody syndrome (APS) and systemic lupus erythematosus was admitted because of severe dyspnea. She had undergone mitral valve replacement (MVR) using a Mosaic bioprosthesis for infective endocarditis 9 years previously. She developed congestive heart failure secondary to mitral bioprosthetic valve stenosis resulting from relatively early structural valve deterioration. She underwent a second MVR using a mechanical valve prosthesis. The explanted bioprosthesis showed marked pannus formation and mineralization with fibrin thrombus formation, especially on the outflow surfaces of the leaflets. After the second operation, she was discharged without APS-related thromboembolic events under meticulous anticoagulant and antiplatelet therapies.
Gen Thorac Cardiovasc Surg 2012 Dec
PMID:Mitral bioprosthetic valve stenosis in a patient with antiphospholipid antibody syndrome and systemic lupus erythematosus. 2258 42

A 50-year-old man with a history of systemic lupus erythematosus and hemodialysis developed acute type A aortic dissection. Computed tomography demonstrated acute type A aortic dissection with chronic distal arch aneurysm and aberrant right subclavian artery that arose from the proximal descending aorta and ran in a retro-esophageal track. Emergent total arch replacement was performed using antegrade cerebral perfusion with circulatory arrest. Both common carotid arteries and the left subclavian artery were chosen as selective cerebral perfusion sites. The right subclavian artery was snared during cerebral perfusion. The right subclavian artery was reconstructed with the right common carotid artery in an end-to-side fashion in the anterior mediastinum. The patient's postoperative course was uneventful, and computed tomography showed excellent blood flow to all four branches. The case description is followed by a discussion of cerebral protection, reconstruction route of the right aberrant subclavian artery and steroids for systemic lupus erythematosus.
Gen Thorac Cardiovasc Surg 2016 Jan
PMID:Emergent total arch replacement for acute type A aortic dissection with aberrant right subclavian artery in a systemic lupus erythematosus patient. 2416 29

Steroids may both be a cause of and treatment for pediatric patients with systemic lupus erythematosus (SLE) presenting with psychotic symptoms. We present two cases demonstrating that careful histories (including prior steroid exposure) and the use of biomarkers can help guide the management of children with SLE presenting with psychosis.
Gen Hosp Psychiatry
PMID:Psychosis in children with systemic lupus erythematosus: the role of steroids as both treatment and cause. 2492 59

Common causes of pulmonary-renal syndrome include anti-glomerular basement membrane (anti-GBM) disease anti-neutrophil cytoplasmic antibody (ANCA) positive vasculitis, and systemic lupus erythematosus. We describe a case of life-threatening pulmonary hemorrhage associated with Campylobacter hemolytic uremic syndrome (HUS), which we believe is a new disease entity. We hypothesize that the cause of this pulmonary-renal syndrome was an immunological reaction to Campylobacter; and that the initiation of high-dose steroids was responsible for the rapid reversal of the patient's pulmonary and renal impairment. The aim of this article is to raise awareness of this unusual cause of a pulmonary-renal syndrome, guiding physicians to recognize it as a potential complication, and to consider high-dose steroids in managing the condition.
J Gen Intern Med 2016 Mar
PMID:Campylobacter-Associated Hemolytic Uremic Syndrome Associated with Pulmonary-Renal Syndrome. 3030 48

Libman-Sacks (LS) endocarditis is one of the most common cardiac manifestations of systemic lupus erythematosus. Rarely, however, it can lead to serious complications, including severe valvular regurgitation or superimposed bacterial endocarditis. We describe the initial diagnostic challenges, clinical course, imaging studies and histopathological findings of a patient who presented with life-threatening lupus complicated by hemoptysis and respiratory failure secondary to a rare complication of LS endocarditis, acute mitral valve perforation. We review the current literature on valve perforation in the setting of LS endocarditis. In conclusion, although the disease is often asymptomatic and hemodynamically insignificant, it can result in serious and potentially fatal complications secondary to valve perforation, which may demand emergency surgical management.
J Gen Intern Med 2016 08
PMID:Mitral Valve Perforation in Libman-Sacks Endocarditis: A Heart-Wrenching Case of Lupus. 2697 91


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