Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

T helper (Th) cells and their cytokines play a pleiotropic role in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a new effector T cell subset, Th9 cells, which preferentially secrete IL-9, has been identified. IL-9 is mainly produced by several T cell subsets including Th9 and Th17, and effective on the functions of Th cells and mast cell. However, there are no unambiguous conclusions that IL-9 contributes to the pathogenesis of SLE. Recently, IL-9 was reported to mediate profound anti-inflammatory effects in several cells or experimental autoimmune models. In particular, IL-9 production seemed to be important in mast cell recruitment. Defect in IL-9/IL-9R axis exhibited a more severe course of Experimental Autoimmune Encephalomyelitis (EAE) and enhanced activity of Tregs, phenotypes reminiscent of SLE. Consistently, IL-9 was implicated in the proliferation of several types of CD4+ T cells, indicating that IL-9 may be therapeutically relevant in SLE. In this article, we briefly discuss the biological features of IL-9 and summarize recent advances on the role of IL-9 in the pathogenesis and treatment of SLE.
...
PMID:Potential roles of IL-9 in the pathogenesis of systemic lupus erythematosus. 2388 12

Interleukin (IL)-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private receptor IL-9R and the IL-2 receptor, gamma (IL-2RG), a common gamma subunit shared by the receptors of many different cytokines. The IL-9R is expressed widely and IL-9 impacts a number of effector cells, such as effector T cells, B cells, innate lymphoid cells, mast cells, polymorphonuclear cells, epithelial cells and smooth muscle cells, playing an important role in regulating inflammatory immunity. The critical role of IL-9 in promoting cellular and humoral immune responses makes it an important focus of potential therapeutic interventions. Recently, a defined subset of T helper type cells, Th9 cells, has been identified by the potent production of IL-9. The involvement of the Th9 cell subset has been described in many types of inflammatory diseases, namely atopic diseases, helminth infections, experimental autoimmune encephalomyelitis and ulcerative colitis. In this review, we summarize the IL-9 biological activities, highlighting roles for IL-9 and Th9 cells in rheumatoid and psoriatic arthritis, systemic vasculitis, systemic lupus erythematosus and systemic sclerosis.
 ...
PMID:Interleukin-9 and T helper type 9 cells in rheumatic diseases. 2715 82