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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study of 36 published cases of adult Still's disease shows the following features: the onset takes place usually during the third decade of life, most often as a polyarthralgia characterized by sometimes starting fever, evanescent rash, neutrophil leukocytosis, negativity of the serological tests for rheumatoid arthritis and systemic lupus; lymphadenopathy and splenomegaly are frequent but not constant; serous cavities, particularly pericardium, are rather frequently involved; evolution is characterized by a succession of relapses and remissions, the far prognosis being rather good (1/3 of cures, 1/3 of mild articular relapses, 1/3 of articular sequelae, involving chiefly neck and hips); corticosteroids and heavy doses of aspirin seem to give the best therapeutic results, the usefulness of a maintenance treatment is debatable.
Sem Hop
PMID:[Adult Still's disease (author's transl)]. 625 65

Seronegative systemic lupus erythematosus is defined as a SLE devoided of antinuclear factors as well as of LE cells when at least 4 out of the 14 ARA criteria are present. We describe herein two case reports and review previous literature concerning this topic. This kind of SLE is characterized by a high incidence of Raynaud's disease, photosensitivity, oral ulcerations, alopecia and perhaps less frequent kidney and central nervous system involvement. The hypotheses about the absence of ANF are discussed. The awareness of such a SLE ("devoided of ANF rather than" seronegative") is to be kept in mind from a chemical, therapeutic and pathophysiologic point of view.
Sem Hop
PMID:[Seronegative systemic lupus erythematosus (author's transl)]. 626 42

In a 44 years old woman, a flare up of polyarthritis becoming positive for sero-reaction at the time of hospitalization, is referred to an earlier unknown SLE. The bilateral optic neuritis which began 15 years earlier, while she was pregnant, simultaneously with a bilateral carpal tunnel syndrome is retrospectively related to the SLE. Such an optic neuritis is rare, its clinical features are specified among the neuro-ophthalmological complications in SLE. Very often optic neuritis is associated with myelopathy. Hypercytosis with moderate elevation of albumin C.S.F., a high level of cyclic GMP, and a low concentration of IgG in C.S.F., are found in central neurological complications in SLE. Other biological alterations are described but both their signification and their interest, as well for diagnostic as for therapeutic supervision, are unknown. Neuropathological findings show either vasculitis or demyelinizing lesions. This case shows the therapeutic problems of such medical situations.
Sem Hop
PMID:[The neuro-ophthalmological complications in SLE (author's transl)]. 626 4

The observation of two cases of thrombophlebitis of the calf which occurred in two sisters within a period of three years is reported. The investigation revealed in both cases the presence of a circulating anticoagulant with anti-prothrombinase activity in association with biological signs of systemic lupus erythematosus (L.E.): anti-DNA antibodies, decreased complement levels, false positive BW reactions. In one patient, the skin biopsy showed a continuous IgM band on immuno-fluorescence. After respectively 4 years and 18 months follow-up both patients are still free from clinical symptoms. A review of the literature is presented and the clinical and etiological significance of the presence of a circulating anticoagulant, its relationship with L.E., particularly with "latent" L.E. (presence of biological signs only), and its association with thrombophlebitis are discussed.
Sem Hop
PMID:[Venous thrombosis, circulating anticoagulant and systemic lupus erythematosus. Two cases reported in two identical HLA sisters (author's transl)]. 627 28

Recent advances have shown that the pathogenesis of systemic lupus erythematosus involves a number of interacting factors. Renal involvement is frequent and is one of the leading factor in the prognosis. Renal histopathology is most important in the management of patients. Immunologic tests may help in the diagnosis and also in the evaluation of diseases activity. Although survival has improved dramatically with the use of corticosteroids, there is as yet no evidence that immunosuppressive drugs may be beneficial.
Sem Hop 1982 Jan 21
PMID:[Recent considerations on systemic lupus erythematosus (author's transl)]. 627 26

The case reported here is the first observation of thrombophlebitis of the superior sagittal and left transverse sinuses in a patient with systemic lupus erythematosus. Thrombophlebitis occurred thirty-six years after onset of SLE. The patient had neither nephrotic syndrome nor serum anti-coagulants. Various hypotheses concerning pathogenesis are suggested. The opportunity for heparin therapy is discussed.
Sem Hop 1982 May 20
PMID:[Thrombophlebitis of the superior sagittal sinus in patient with systemic lupus erythematosus (author's transl)]. 628 5

Acute glomerulopathy due to pneumococcal infection occurred in a patient with chronic discoid lupus. The onset of renal involvement in this context suggested that cutaneous lupus may have developed into systemic lupus erythematosus. Renal biopsy established the correct diagnosis. The physiopathology of glomerular involvement in lupus and infections is discussed. Attention is drawn to the significance of complement activation, either by the classical or the alternative pathways according to the etiology.
Sem Hop 1982 May 20
PMID:[Proliferative glomerulopathy in pneumococcal septicemia in a patient with lupus (author's transl)]. 628 6

High toxoplasma antibody titers have been reported in polymyositis and other connectivitis with myositis. The authors describe a case of systemic lupus erythematosus with polymyositis and high titers of IgG toxoplasma antibodies. Studies of muscle biopsy specimens by immunofluorescence and inoculation of mice with muscle extracts failed to demonstrate the presence of Toxoplasma gondii. The nature of the toxoplasmic agression is discussed. It may be that reactivation of a previous infection due to the rupture of cysts was promoted by the immunologic disorders and complement deficiency related to systemic lupus erythematosus.
Sem Hop 1983 Jan 06
PMID:[Systemic lupus erythematosus, polymyositis and toxoplasma antibodies]. 629 86

Lupus panniculitis usually affects the hypodermis and the dermis profundus (Irgang's lupus profundus). In our case, the systemic lupus erythematosus was preceded by an intraabdominal panniculitis, occurring as a voluminous tumor. Histological examination showed the usual picture of panniculitis, but there were also severe fibrinoid necrotic lesions, which should have alerted us. Lupus must be included among the etiologies of intraabdominal panniculitis.
Sem Hop 1982 Dec 30
PMID:[Pseudo-tumorous panniculitis of the mesentery. An unusual initial stage of acute lupus erythematosus in a 10-year-old girl]. 630 53

Systemic lupus erythematosus (SLE) is a polymorphic disease of unknown origin, characterized by many stigmata of autoimmunization which allow a biological diagnosis. Besides non-specific inflammatory disorders, considerable alterations of humoral and cellular immunity are found. The hallmark of the disease is the presence of anti-double-stranded-desoxyribonucleic acid (anti-ds DNA) antibodies, detected by the Farr radioimmunologic method or the crithidia luciliae immunofluorescence technique, both of which are nearly specific for SLE. The clinical significance of other types of anti-nuclear antibodies is unclear. Serial evaluations of antinuclear antibodies, complement fractions, circulating immune complexes, and, above all, immune complexes bound to target organs (kidneys, skin, synovial membranes) are needed to follow the course of the disease. The demonstration of abnormal suppressor T-cell activity has led to current pathogenic hypotheses and ongoing therapeutic trials with immunoregulating drugs.
Sem Hop 1983 Apr 14
PMID:[Biological diagnosis of systemic lupus erythematosus]. 630 98


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