Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024141 (
systemic lupus erythematosus
)
44,322
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We studied the in vitro production of interleukin-2 (IL-2), the expression of IL-2 receptors, the absorption of IL-2, and spontaneously expanded suppressor cell function by mononuclear cells from 15 patients with
systemic lupus erythematosus
(
SLE
) and 15 healthy control subjects. These functions were studied in the presence or absence of
AS-101
, a recently described organotellurium compound with immunoregulatory properties.
AS-101
was found to be non-toxic to cells from both patient and control groups; it increased the production of IL-2, elevated the percentage of Tac-positive cells even among cells that had been pre-treated with pronase, and ameliorated the absorption of IL-2. It also enhanced the suppressor cell function in cells from
SLE
patients. Since these functions are known to be defective in vitro in cells of
SLE
patients, and since preliminary testing of
AS-101
in humans indicates that it is a safe drug, this immunoregulatory compound holds promise for a novel and effective treatment of
SLE
.
...
PMID:Effect of the new immunoregulator AS-101 on in vitro functions of mononuclear cells from patients with systemic lupus erythematosus. 253 12
