Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The similarities between human and canine systemic lupus erythematosus are enumerated, using the incidence of symptoms reported for man as a guide to the possible incidence of clinical signs in the dog. Differences between the human and canine diseases are listed. Four clinical cases of the disease are reported. Diagnostic procedures were confined to the observation of clinical signs and serological and haematological methods.
J S Afr Vet Assoc 1976 Dec
PMID:Canine systemic lupus erythematosus. The disease, clinical manifestations and treatment. 101 95

Pneumatosis intestinalis in association with connective tissue diseases is an unusual combination whose pathogenesis is not yet understood. Furthermore, steroid medication, often used to treat these diseases, may itself cause pneumatosis. Three cases of scleroderma, systemic lupus erythematosus, and amyloidosis in association with pneumatosis and without prior steroid therapy are presented. The small vessel occlusive pathologic processes in these diseases may cause focal areas of mucosal ischemia resulting in small, perhaps transient ulcerations that allow gas to enter the gut wall from the lumen.
South Med J 1976 Dec
PMID:Pneumatosis intestinalis in association with connective tissue disease. 101 66

In our article is referred to the recognition of collagenosis in the demarcated whole district with 100,000 inhabitants. The occurrence of these diseases is lower than the occurrence of other rheumatic diseases. Our results as well as the observations of other authors confirm that the lupus erythematodes and the diffuse sclerodermia are not rare diseases even in our circumstances and with their evolution tendency they shorten the lives of the affected persons. The high recognition coefficient with large probability corresponds to the real incidence of these two diseases, which can be achieved only by an observation of many years and repeated controls of the correctness of the diagnosis.
Z Gesamte Inn Med 1976 Dec 01
PMID:[Screening of collagen diseases in the years 1961-1972 from a selected population sample]. 102 Apr

Antibodies to ultraviolet light denatured DNA (UV DNA) have been measured in patients with systemic lupus erythematosus (SLE) and normal subjects, using a millipore filter radioimmunoassay. High levels of UV DNA binding were only found in patients with SLE. The presence of UV DNA antibodies correlated well with the presence of native DNA antibodies, although immunodiffusion studies and inhibition techniques showed these antibodies to be immunologically distinct in many cases. Forty-one per cent of the SLE patients had had photosensitivity at some stage of their disease, but there was a poor correlation between this symptom and the presence of UV DNA antibodies. Although UV DNA is known to be a potent immunogen, none of the results from this study suggests that antibodies to UV DNA are more than another example of the broad spectrum of antinuclear antibodies seen in SLE.
J Rheumatol 1976 Dec
PMID:Antibodies to UV light denatured DNA in systemic lupus erythematosus: detection by filter radioimmunoassay and clinical correlations. 102 71

Prevalence of cytoplasmic antibodies--smooth muscle antibodies (SMA), gastric parietal cell antibodies (GPA), and mitochondrial antibodies (MTA)--was evaluated in 148 normal persons and 168 patients by indirect immunofluorescent method. Their prevalence in normal persons was 0%, 2% and 0% for SMA, GPA and MTA respectively, while SMA and MTA were positive in 5.7% and 8.6% of the 35 systemic lupus erythematosus (SLE) patients respectively. The difference in the prevalence of SMA and MTA between these two groups was statistically significant. The higher prevalence of these antibodies and the occurrence of various kinds of antibodies in SLE patients support the thesis that SLE is an autoimmune phenomenon.
Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi 1976 Dec
PMID:Prevalence of cytoplasmic antibodies in systemic lupus erythematosus. 103 34

Antigen-ginding lymphocytes capable of binding native DNA (DNA-ABC) were identified in the peripheral blood of normal controls and patients with systemic lupus erythematosus (SLE) by autoradiography with 125I-nDNA. 12 patients with active SLE had 404 +/- 273 (mean +/- SD) DNA-ABC/105 lymphocytes, while 7 inactive SLE patients and 13 normals had 120 +/- 48 and 48 +/- 36, respectively. All three groups were significantly different from one another (p less than 0.01). No significant correlation was detected between the quantity of anti-native DNA (nDNA) antibody and number of DNA-ABC; however, most patients with large amounts of anti-nDNA antibody had both active disease and large numbers of DNA-ABC. Numbers of DNA-ABC and lymphocytes with surface immunoglobulin (Ig) did not change significantly after an 18-h incubation at 37degreeC. After depletion of B-lymphocytes by passage over bead columns coated with a complex of IgG and anti-IgG, the great majority of DNA-ABC were removed in both normal subjects and SLE patients. Labeling lymphocytes sequentially with 125I-nDNA, followed by an indirect fluorescence technique for identification of surface Ig, indicated that the great mahority of radiolabeled cells had surface Ig by fluorescence microscopy in four normals (average 93%) and five patients with active SLF (average 82%). The predominance of nDNA-sensitive B-lymphocytes in the peripheral blood of both normals and SLE patients is consistent with the concept that the induction of the anti-nDNA antibody response is due to the stimulation of preexisting nDNA-specific B lymphocytes by mechanisms other than those necessarily involving participation of nDNA-specific T lymphocytes.
J Clin Invest 1975 Dec
PMID:Identification of DNA-binding lymphocytes in patients with systemic lupus erythematosus. 108 49

A 23-year-old woman with a nine-month history of SLE, uncontrolled with high daily doses of steroids, was treated with the T-cell immunostimulant drug, levamisole. Following a single oral three-day course of therapy with this agent her immunologic parameters and clinical manifestations underwent marked regression. Continuous two-weekly course of this drug at three days per course have allowed rapid reduction of her steroid and resulted in complete remission of her symptoms. The theoretical considerations for the use of levamisole dovetailed perfectly with the observed response to this agent.
Ann Allergy 1975 Dec
PMID:The treatment of systemic lupus erythematosus (SLE) with the T-cell immunostimulant drug levamisole: A case report. 108 57

A patient with systemic lupus erythematosus developed acute mitral regurgitation due to ruptured chordae tendineae, requiring mitral valve replacement. Typical changes of Libman-Sacks endocarditis were observed in the excised mitral valve. Immunofluorescent studies revealed antinuclear antibody and deposits of immunoglobulins and complement within small vessels.
J Rheumatol 1975 Dec
PMID:Acute mitral regurgitation from ruptured chordae tendineae in systemic lupus erythematosus. 108 31

The incidence of autoantibodies to various nuclear antigens was studied in 64 patients with SLE, 137 patients with various connective tissue diseases, 63 other patients and 90 controls. A positive correlation was found between SLE, nephritis, and the presence of antibody against native DNA. Antibody to denatured DNA showed no specificity for SLE and was correlated with the absence of nephritis. Antibody to RNA-protein occurred mainly in SLE, regardless of the presence or absence of nephritis.
Schweiz Med Wochenschr 1975 Dec 13
PMID:[Antibodies against various nuclear antigens (especially DNA and RNA proteins) in disseminated lupus erythematosus with and without kidney involvement and in other collagen diseases. Preliminary report]. 108 42

Antibodies specific for polyriboadenylic acid (poly rA) are present in sera from patients with systemic lupus erythematosus and from NZB/NZW F1 mice. The specificity of these antibodies was established by inhibition of [3H]poly rA binding and by affinity chromatography. Poly rA binding was associated with the 19S and 7S regions when serum was fractionated by sucrose density gradient untracentrifugation. Young NZB/NZW F1 mice (1-5 months) had only 19S anti-poly rA, whereas old NZB/NZW F1 mice (2 years) had activity in both 19S and 7S regions, suggesting a possible age-dependent switching mechanism in the spontaneous development of antibodies to nucleic acids. The gamma-globulin fraction from an SLE patient was subjected to affinity chromatography on a column of poly rA covalently linked to Sepharose. An enriched population of IgG antibodies binding only poly rA, but not native or denatured DNA, was isolated in this manner. This procedure may have broad biological applicability for the preparation of isolated immunospecific anti-nucleic acid antibodies.
Clin Exp Immunol 1975 Dec
PMID:Antibodies binding polyriboadenylic acid in systemic lupus erythematosus. Immunochemical characterization and isolation by affinity chromatography. 108 83


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