Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prevalence of cytoplasmic antibodies--smooth muscle antibodies (SMA), gastric parietal cell antibodies (GPA), and mitochondrial antibodies (MTA)--was evaluated in 148 normal persons and 168 patients by indirect immunofluorescent method. Their prevalence in normal persons was 0%, 2% and 0% for SMA, GPA and MTA respectively, while SMA and MTA were positive in 5.7% and 8.6% of the 35 systemic lupus erythematosus (SLE) patients respectively. The difference in the prevalence of SMA and MTA between these two groups was statistically significant. The higher prevalence of these antibodies and the occurrence of various kinds of antibodies in SLE patients support the thesis that SLE is an autoimmune phenomenon.
Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi 1976 Dec
PMID:Prevalence of cytoplasmic antibodies in systemic lupus erythematosus. 103 34

From January, 1979 to December, 1990, 105 pregnancies of the 87 mothers with systemic lupus erythematosus (SLE) were studied. There were 15 (14.29%) fetal losses. Among the 90 livebirths, 23 (25.5%) were moderately premature; and 1 (1.1%), was extremely premature. All but 2 (2.2%) had an Apgar score more than 7 at 1 minute. There was no neonatal death. Significantly lower birth body weights were noted compared with the matched control group (p = 0.0001). Birth body length and head circumference were not different. Only 1 of the 13 newborns who had been small for gestational age at birth had body weight and length less than the 3rd percentile during follow-up. Three (3.3%) newborns presented as congenital complete atrioventricular block (CCAVB). Their mothers were all positive for SSA (Ro) antibody. One of them obligatorily needed pacemaker implantation. ECG abnormalities including multiple ventricular premature contractions, wandering atrial pacemaker, sinus arrhythmia, and first degree A-V block were detected in another six newborns. Congenital cardiac defect with secundum type atrial septal defect was noted in two newborns (2.2%). Among the 59 mothers who had been tested for SSA antibody, 29 (49.1%) were positive. The incidence of complete A-V block was significantly higher in newborns of mothers with SSA antibody (p < 0.001). On the contrary, the frequency of fetal loss has higher in newborns of mothers without SSA antibody (p = 0.0043).
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Newborns of Chinese mother with systemic lupus erythematosus (SLE). 129 44

Since 1981 when anti-Ro (SS-A) and/or anti-La (SS-B) antibodies were described to be present in infants with neonatal lupus erythematosus (NLE) and their mothers, subsequent studies have demonstrated the almost universal association of NLE with either or both of these autoantibodies. To our best knowledge, three cases of NLE were reported to be negative in anti-Ro (SS-A) and anti-La (SS-B) antibodies. We report one infant born to a mother with systemic lupus erythematosus (SLE). He had neonatal pancytopenia (thrombocytopenia, anemia, and leukopenia) which got resolved after intravenous immunoglobulin (IVIG) administration. Both anti-Ro (SS-A) and anti-La (SS-B) antibodies were not detectable in his serum by immunodiffusion method while other such as RNP (nonspecific, including U1,U2,U3,...,U6), Sm and Scl-70 antibodies were all positive. This mother had all the above antibodies detectable in her serum. After excluding other possibilities, his pancytopenia was most likely to be attributed to neonatal lupus. We suggest that autoantibodies such as RNP and Sm antibodies may play an important role in the pathogenesis of thrombocytopenia of NLE.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Neonatal lupus erythematosus with negative anti-Ro and anti-La antibodies: report of one case. 129 48

Excessive fetal morbidity and mortality have been noted in patients with systemic lupus erythematosus (SLE). The influence of anti-SSA/Ro antibodies on fetal outcome in SLE patients has rarely been reported, but its high association with congenital heart block or neonatal lupus syndrome is well known. In 430 pregnancies of the 154 SLE patients studied, there was an increased frequency of adverse fetal outcome compared with controls. There was no significant difference in the rates of adverse fetal outcome between anti-SSA/Ro positive and negative SLE patients, except that the incidence of intrauterine growth retardation increased in the positive patients. However, pregnant SLE patients with high titer of anti-SSA/Ro antibodies had more adverse fetal outcomes. All three infants who suffered congenital heart block/neonatal lupus syndrome were associated with maternal anti-SSA/Ro antibodies. The frequency of congenital heart block/neonatal lupus syndrome was 0.79% (3/379) in livebirths of all SLE patients and 1.17% (3/257) in live-births by anti-SSA/Ro positive SLE mothers.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1992 Feb
PMID:The influence on pregnancy of anti-SSA/Ro antibodies in systemic lupus erythematosus. 130 46

The Widal test was performed on 90 blood specimens from typhoid fever patients, on 21 blood specimens from nontyphoid salmonellosis patients and on 46 nontyphoid febrile patients. Of 90 typhoid fever patients, 58 (64.4%) had H agglutinin titer of 1:160 or more and 55 (61.1%) had O agglutinin titer of 1:160 or more. Salmonella typhi H and/or O titer of 1:160 or more occurred in 70 (77.8%) of 90 typhoid fever patients and in 5 (23.8%) of 21 nontyphoid salmonellosis. Only one of the 46 (2.2%) nontyphoid febrile patients showed O agglutinin titer of 1:160, a case which was proven subsequently to be a case of systemic lupus erythematosus. Either O or H can reach to diagnostic level during the first week of typhoid fever, and can be helpful in diagnosis of the illness. In view of the high specificity (91.0%), sensitivity (77.8%) and accuracy (83.4%), the Widal test still has value in the diagnosis of typhoid fever.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1985 Nov
PMID:Diagnostic value of a single Widal test. 241 86

A female newborn of SLE mother developed transient typical discoid-like lupus skin lesions over her face soon after birth and had severe relapse with generalized spreading following an episode of upper respiratory tract infection at 50 days of age. Blood picture showed anemia, transient thrombocytopenia and high ESR. Cardiac echo disclosed small ASD with minimal TR. Both EKG and 24 hrs EKG monitor presented normal findings. Serological studies at the early relapse stage of this disease showed increased serum ANA, IgA and IgM level with normal IgG and decrease of C3 and C4. Both Ro(SSA) and La(SSB) antibody systems were positive in mother but only positive for La(SSB) antibody system in this baby. The alpha-anticardiolipin antibody was negative. We suggest that the Ro(SSA) and/or La(SSB) antibody systems may play a role in the pathogenesis of neonatal lupus erythematosus.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
PMID:Neonatal lupus erythematosus: report of one case. 263 97

Patients with systemic lupus erythematosus (SLE) often possess antibodies against two nuclear antigens, designated "Sm" and "RNP". The exact relationship between Sm and RNP is not clear; the present study was conducted to define these two different nuclear antigens. Rabbit thymus extracts were used to obtain purified Sm/RNP complex and free Sm antigens by using a combination of 25-60% ammonium sulfate precipitation, DEAE-Sephacel and hydroxylapatite chromatography. By using the separated antigens, sera characterized as anti-Sm, anti-Sm/RNP and anti-RNP could be distinguished by enzyme-linked immunosorbent assay (ELISA). Anti-Sm and/or anti-RNP antibodies were detected in 32 (52%) of 62 sera from patients with SLE. Of these 32, 6 contained anti-Sm only, 10 contained anti-RNP only and 16 had both. When HeLa nuclear extracts were used as antigens by immunoblotting, sera with anti-RNP reacted primarily with 2 polypeptides of 68 and 45 KD; sera with anti-Sm recognized mainly on 2 polypeptides of 26 and 14 KD; sera with anti-Sm/RNP recognized both groups. When purified Sm/RNP complex from rabbit thymus extracts was used as antigen by immunoblotting, sera with anti-RNP reacted with 68 KD protein and putative degradation products of the 68 KD protein. (major: 63 KD, 45 KD, 40 KD; minor: 54-47 KD); sera with anti-Sm recognized 14 KD protein; sera with anti-Sm/RNP reacted with both groups. Although Sm and RNP can exist as a Multimolecular complex, the epitopes recognized by anti-Sm and anti-RNP differ greatly. The Sm determinants reside primarily on proteins of 26 KD and 14 KD, whereas the RNP determinants reside mainly on a protein of 68 KD.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1989 Feb
PMID:Molecular characterization of the SM and RNP nuclear antigens. 279 19

The autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus was lower than that of normal individuals (p less than 0.05). The impairment was not due to the dysfunction of various regulatory lymphocytes, but there was a negative correlation with the B cell function. The low autologous mixed lymphocyte reaction was found in patients with high B cell function.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1985 Nov
PMID:[Autologous mixed lymphocyte reaction in systemic lupus erythematosus]. 293 73

Interleukin-2 receptor (IL-2R) is expressed on activated lymphocyte after stimulation with antigen or interleukin-2 (IL-2), meanwhile soluble form of the receptor is released. Using enzyme-linked immunosorbent assay, serum IL-2R levels were determined in 34 healthy controls, 61 patients with systemic lupus erythematosus (SLE) and 32 patients with rheumatoid arthritis (RA), yielding mean +/- SD values of 355 +/- 89, 807 +/- 453 and 567 +/- 210 U/ml respectively. In both SLE and RA patients, the active disease group had more markedly elevated serum IL-2R levels compared with those of the inactive group. In patients with SLE, elevated serum IL-2R is associated with lymphopenia, renal disorders, decreased C3 level and increased anti-DNA, thus make it a good parameter to monitor disease activity in SLE.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1988 Feb
PMID:Serum interleukin-2 receptor in systemic lupus erythematosus and rheumatoid arthritis. 326 81

A retrospective study was made of 137 children with systemic lupus erythematosus (SLE) seen at the Veterans General Hospital in the past 12 years. There were 116 females (84.7%), and 21 males (15.3%). The peak ages of onset were 13-14 years and 16-17 years. Malar rash, arthritis and fever were the most common presentations, as in previous studies. Central nervous system (CNS) involvement occurred in 24 cases (17.5%), and renal disorder was noted in 77 cases (56.2%). Renal biopsy in 67 cases showed a pathological transformation rate of 16.1% (5/31). Ten patients died during the study period, with renal insufficiency the primary cause of death.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1987 Feb
PMID:Systemic lupus erythematosus in children. 359 62


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