Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024141 (
systemic lupus erythematosus
)
44,322
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We examined the activities of peptidases in plasma and tissues of the New Zealand Black (NZB) mouse as an animal model of human
systemic lupus erythematosus
, and also in serum from patients with rheumatoid arthritis and
systemic lupus erythematosus
. Activities of dipeptidyl peptidase II (DAP II) and
post-proline cleaving enzyme
(PPCE) were increased, and dipeptidyl peptidase IV (DAP IV) activity was decreased in plasma and spleen of NZB mice, as compared with the control BALB/c mice. Likewise, the activity of DAP II was increased and that of DAP IV was decreased in serum of patients with rheumatoid arthritis and
systemic lupus erythematosus
. These results indicate the importance of hydrolytic enzymes in the pathogenesis of autoimmune diseases.
...
PMID:Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in mice with lupus erythematosus-like syndrome and in patients with lupus erythematosus and rheumatoid arthritis. 288 36
We investigated the changes in the activities of proteases and other hydrolytic enzymes in spleens of MRL mice as a model of systemic
lupus
erythematodes (SLE). Although there are various abnormalities in the activities of proteases in the spleens of such animals, a multivariate study helped to extract two important components. The first component, representing the activities of serine proteinases, tended to decrease with advancing age in MRL mice but not in control animals. The second component, representing Pro-IP and
prolyl endopeptidase
, tended to decrease with advancing age in control animals, but not in the MRL mice. The discrepancy between these two components may be related to the immunopathologic disturbances in this model.
...
PMID:Dissociation between serine proteinases and proline related enzymes in spleen of MRL mouse as a model of systemic lupus erythematodes. 329 60
