Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of lupus erythematosis is described, unusual because severe thrombosis occurred before diagnosis of the lupus symptoms and because the patient recovered after stopping oral contraception. The 24-year-old woman had been taking combined pills (2.5 mg lynestrenol and .075 mg mestranol) for 1 year. She experienced chest, foot, and calf pain and stopped working, then sought emergency hospitalization 3 weeks later for intense dyspnea and pain in both legs. She had no femoral pulse, and a clot was removed from the right femoral artery; 2 more clots were found in the pulmonary vessels and the aorta. She was treated with heparin (Calciparine sc) for 6 weeks. A few days after stopping anticoagulants, she was hospitalized again with right chest pain, anemia, swollen glands, but no skin lesions or lupus cells. Endos copy revealed lupus erythematosis lesions on the liver and spleen. She also had elevated IgG, IgM, alpha-glucoproteins, and an antinuclear antibody titer of 1/500. A 3-month pregnancy ended in spontaneous abortion when anticoagulants were supplemented with strong corticoids (60 mg/day prednisone). 1 month later she was fully recovered. The oral contraceptive may have precipitated the lupus, since it regressed after stopping and was aggravated again by pregnancy.
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PMID:[Thrombosing disease in the course of a lupic syndrome revealed by an estroprogestational agent]. 515 Mar 17