Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Promising new developments involving four anti-HIV agents are described. HE2000, a new treatment for end-stage disease, may interrupt HIV's entry into cells, thus preventing damage. Norvir-SGC, a new gel-capsule form, available June or July 1999, should aid in eliminating the foul taste of the drug, and lessen the chance of diarrhea. New studies of Anadrol-50, a drug promoting lean muscle growth, suggest it is not metabolized by the same liver pathway as most drugs used to treat HIV. Therefore, it probably will not interact with drug "cocktails" or highly active antiretroviral therapy regimens. Research indicates that hydroxychloroquine, a drug for managing rheumatic illness and lupus, may disrupt HIV's attachment to key immune cells including macrophages. However, clinical trials are not being done with this inexpensive drug in favor of using more expensive drugs.
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PMID:Drug watch. 1136 96