Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the effect of Lipo-PGE(1), a prostaglandin (PG) E(1) preparation used to treat cutaneous ulcers associated with systemic sclerosis (SS) and systemic lupus erythematosus (SLE), on health-related quality of life (HR-QOL) using the Medical Outcome Study 36-item Short-Form Health Survey (SF-36) questionnaire. A total of 192 SS and SLE patients were treated for 3 months. At baseline the scores for each of the five SF-36 subscales were significantly lower than the age- and sex-adjusted standard values for the Japanese general population. After treatment, mean (+/- SD) SF-36 scores for body pain and general health perception significantly increased from 48.6 +/- 24.1 to 55.3 +/- 26.1 and from 36.8 +/- 16.7 to 40.2 +/- 17, respectively. Emotional QOL parameters including vitality and mental health, however, showed no improvement. Physician-rated symptom scores significantly improved after administration of Lipo-PGE(1). In conclusion, Lipo-PGE(1) improved both cutaneous ulcers and HR-QOL, especially physical QOL.
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PMID:Effect of Lipo-PGE1 on health-related quality of life in patients with systemic sclerosis and systemic lupus erythematosus in Japan. 1823 Feb 78

To identify the impact of systemic lupus erythematosus (SLE) on health-related quality of life (HRQoL) domains compared with the results of healthy controls by systematically reviewing the literature. A systematic literature search was performed on MEDLINE, Web of Science and EMBASE until April, 2018 to obtain eligible studies reporting mean and standard deviation scores for each domain of the 36-item Short-Form Health Survey (SF-36) in SLE patients and healthy controls. Random effect model was performed to summarize the scores of each domain. The forest plot was used to compare the scores of SLE patients with healthy controls. Review Manager (version 5.3) was adopted in the meta-analysis. In all, 13 studies were included in the work, including 1279 SLE patients and 1466 healthy controls. Compared with controls, patients with SLE had lower scores in all SF-36 dimensions (physical function, physical role function, body pain, general health, vitality, social function, emotional role function, mental health), especially in the physical role function. SLE does impair HRQoL to varying degrees. It is indispensable to measure and assess HRQoL of SLE patients regularly, which contributes to formulate targeted interventions appropriately and provide effective ways of management of the disease positively.
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PMID:The impact of systemic lupus erythematosus on health-related quality of life assessed using the SF-36: a systematic review and meta-analysis. 3094 91