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Target Concepts:
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Query: UMLS:C0024141 (
systemic lupus erythematosus
)
44,322
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Patients with
systemic lupus erythematosus
(
SLE
) have a chance of developing liver involvement in their lifetime. The main cause of liver involvement in
SLE
patients is previous treatment with hepatotoxic drugs or hepatotropic viral hepatitis. Wilson's disease is a hereditary disorder and is usually diagnosed in patients presenting either neuropsychiatric disorders or manifestations related to chronic liver disease. Fulminant hepatic failure as the initial manifestation of Wilson's disease is rare. The relationship between
systemic lupus erythematosus
and Wilson's disease has not been established. We report a case of a 12-year-old girl with
SLE
who presented fulminant hepatic failure as an initial manifestation of Wilson's disease. The diagnosis was established with decreased serum ceruloplasmin level and the presence of
Kayser-Fleischer ring
. We treated with repeated plasma exchange. Despite repeated plasma exchange she died of multi-organ failure on the 16th hospital day. Considering this case, Wilson's disease should be considered as a cause of fulminant hepatic failure, especially in juvenile age cases.
...
PMID:[A case of fulminant hepatic failure in Wilson's disease combined with systemic lupus erythematosus]. 1249 22
The authors report a female case of
systemic lupus erythematosus
(
SLE
) that was diagnosed as Wilson's disease (WD) when neurological manifestations were evident three years after the first admission. The brain imaging studies showed bilateral symmetrical basal ganglia involvement, slit lamp examination revealed
Kayser-Fleischer ring
of the cornea, and 24-hour urinary copper and serum ceruloplasmin also confirmed the diagnosis. The patient also had hemolytic anemia and hypoparathyroidism, which are rare presenting features of WD.
SLE
may be associated with WD, and presence of neurological, behavioral, or liver function abnormalities should raise the suspicion, even without apparent features of WD.
...
PMID:Systemic lupus erythematosus, hypoparathyroidism, and hemolytic anemia in a patient with Wilson's disease. 3154 51
