Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a young girl, aged 17 years, there occurred, 9 months after starting treatment with isoniazid and rifampicin, clinical signs of rheumatoid arthritis with facial erythema of vespertilio type. The presence of L.E. cells and antinuclear antibodies with a high titer, the rapid disappearance of all the clinical signs on stopping isoniazid, and the transient exacerbation of the syndrome on giving a single dose of isoniazid, gave the diagnosis of systemic lupus erythematosus induced by isoniazid. 18 months after stopping the drug, the patient is apparently cured, but there persists in the serum antinuclear antibodies in low concentration (1/200). A study of acetylation of isoniazid in this patient and her 3 sisters, showed that they were all of the slow acetylating phenotype. The late prognosis of this disease and the physiopathological value of the slow acetyl phenotype are worth discussion.
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PMID:[Lupus syndrome during treatment with isoniazid]. 5 40

A woman with cutaneous vasculitis had a severe bullous eruption that was suggestive of erythema multiforme. The patient also had a history of recurrent urticaria that continued intermittently for over a year of follow-up examination. Skin biopsy specimens of both urticarial and erythema and multiforme lesions showed leukocytoclastic vasculitis. An illness resembling systemic lupus erythematosus (SLE) is suggested by transient, low-titer, positive antinuclear antibody tests, persistent deposits of immunoglobulin and complement in normal skin, arthralgias, circulating immune complexes, and chronic hypocomplementemia. This case is similar to cases previously reported as "hypocomplementemic vasculitis," an "unusual SLE-related syndrome," and "urticaria with vasculitis."
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PMID:Urticarial vasculitis: report of a case and review of the literature. 15 33

Antibodies to soluble ribonucleoprotein (sRNP) are by definition a prerequisite for the diagnosis mixed connective tissue disease (MCTD). They are also found in 30--40% of other rheumatic conditions with a high titred speckled IFL reaction. The same is true for the most characteristic clinical features of MCTD, viz. Raynaud's syndrome and polymyositis--polymyalgia. The serological and clinical symptoms mentioned are closely associated. An association between anti-Sm and the SLE symptoms butterfly erythema, nephropathia, other visceropathias and cerebrovascular disease is confirmed by the present study. Although anti-Sm has less diagnostic specificity for SLE than has anti-ds-DNA, it is useful as a diagnostic aid in SLE cases lacking the latter antibody. The results of the present study tend to support the hypothesis that anti-sRNP may be associated with a prophylactive effect against serious vasculitis and nephropathia. When anti-sRNP and anti-Sm occur together they seem to act competitively so that the symptom associated with the antibody having the highest titre tends to dominate the clinical picture. Both anti-sRNP and anti-Sm produce speckled nuclear patterns in the indirect immunofluorescence test. Sera with immunofluorescence titres below 1/25 were not found to react against either sRNP or Sm. On the other hand all sera tested that had a speckled IFL reaction greater than or equal to 1/800 also had anti-sRNP.
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PMID:Symptomatology and diagnosis in connective tissue disease. II. Evaluations and follow-up examinations in consequence of a speckled antinuclear immunofluorescence pattern. 36 40

A review of inflammatory subcutaneous disease revealed that lymphoid follicles are observed frequently in lupus panniculitis. They are found rarely in other lymphocytic inflammatory diseases involving the panniculus, such as morphea, erythema nodosum, and erythema induratum. The lymphoid follicle may be an indication of immunoreactive and connective tissue disease, and cases should be evaluated with this in mind.
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PMID:Lymphoid follicles in subcutaneous inflammatory disease. 43 65

beta-Carotene and canthaxanthin in a dose of 75--250 mg a day by mouth reduced the symptons of exposure to the sun in all 7 treated patients with erythrohepatic protoporphyria (EPP), in 15 of 18 with polymorphous light eruptions (PMLE) and in 3 of 4 with lupus erythematodes discoides. In the EPP group the protoporphyrin level tended to vary inversely with that of the serum carotenoids. The level of retinol-binding protein in plasma remained unchanged despite a substantial rise in the concentration of the serum carotenoids. Estimation of the minimal erythema dose for unfiltered light from a Xenon lamp in 7 patients with PMLE showed an increase in only 1 patient. Neither clinical examination nor repeated laboratory studies revealed any serious side effects of the treatment.
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PMID:Oral carotenoids for photohypersensitivity in patients with erythrohepatic protoporphyria, polymorphous light eruptions and lupus erythematodes discoides. 57 Jan 77

Three infant boys with a centrifugal annular erythema mainly consistent with erythema annulare centrifugum, developing a few weeks after birth, are described. The lesions disappeared before the age of 6 months, without atrophy, and during this period the infants were otherwise healthy. This group is considered to belong to one of three types of reactivity in infants associated with or expressed as a connective tissue disease, especially lupus erythematosus, in the mother and child or in either. In type 1, signs and symptoms of systemic lupus erythematosus are or will be present in the mother and the child displays discoid lupus erythematosus lesions at birth or soon after. In type 2, the mother has the same signs and symptoms as in type 1 but the child develops a centrifugal annular erythema 3-6 weeks after birth. In type 3, discoid lupus erythematosus is present at an early stage in the infant, while the mother is healthy. This type may represent an early onset of lupus erythematosus in the infants.
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PMID:Annular erythemas in infants associated with autoimmune disorders in their mothers. Report on three cases. 85 42

A review of medical history concerning case history reports of adverse clinical manifestations of hormonal contraceptives is presented. The unusual complicatons described are: gingivitis, dilation of the ureters, masculinization of the female fetus, candidiasis, ischemic colitis, megaloblastic anemia, chorea, alopecia, chloasma pigmentation, prophyria, photosensitivity, herpes gestationis, lupus, erythematous syndrone, erythema modosum and corneal irritation. The pathophysiology of the lesion and its relation to hormone action are presented.
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PMID:Unusal signs and symptoms associated with oral contraceptive medication. 110 27

There are many causes of malar erythema besides the classic butterfly rash of acute cutaneous lupus erythematosus (LE). Twenty-one patients (6.7% of new patient visits) referred to a dermatology department-based rheumatic skin disease subspecialty clinic over a 5-year period in whom a diagnosis of cutaneous LE had been entertained were found to have diagnoses other than autoimmune connective tissue diseases. Sixteen of the patients in this cohort (76%) had acne rosacea (rosacea), while the remaining five had other dermatologic disorders. Review of their records revealed that upon referral nine of these 21 patients (43%) had positive antinuclear antibody (ANA) assays, most with insignificant or marginal titers by our laboratory standards. On repeat ANA testing in our laboratory, all of these patients had insignificant ANA titers. Physicians may be giving too much weight to low-titer ANAs in assessing patients with isolated malar erythema. These issues are discussed in the overall context of the differential diagnosis of malar erythema. A simple punch skin biopsy can be very helpful in distinguishing cutaneous LE from other causes of malar erythema.
Lupus 1992 Aug
PMID:Prevalence of acne rosacea in a rheumatic skin disease subspecialty clinic. 130 86

An SLE patient developed aseptic necrosis of the right scaphoid bone 4 years after an episode of aseptic necrosis of bilateral femoral heads caused by corticosteroid treatment. Since the aseptic necrosis of the right scaphoid bone was preceded by the insidious exacerbation of SLE as evidenced by facial erythema, it was considered to be a result of vasculopathy due to active SLE. It took 14 months to make a correct diagnosis of the aseptic necrosis of the scaphoid bone by a chanced roentgenogram for the routine evaluation for osteoporosis. Therefore, the importance of an awareness of this possibility and repeated radiographic examinations is emphasized for the correct diagnosis of joint manifestations in SLE.
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PMID:Aseptic necrosis of unilateral scaphoid bone in systemic lupus erythematosus. 139 84

A 33-year-old woman with a 9-year history of psoriasis developed a severe SLE with no signs of visceral involvement during a 3-week exposure to PUVA (psoralen and UVA) therapy. The patient fulfilled the criteria of the American Rheumatism Association (25) for the diagnosis of SLE. She showed dermatological lesions including facial erythema, photo-sensibility arthritis, hematological disorders including leuko-, lympho-, thrombocytopenia, antinuclear antibodies, and dsDNA antibodies. With a therapy that included corticosteroids, chloroquine, and azathioprine the disease could be controlled. The coincidence of a PUVA therapy and the first flare-up of an SLE demonstrates a possible pathogenic role of UV light in SLE.
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PMID:[Significance of ultraviolet light in the pathogenesis of systemic lupus erythematosus: case report and discussion of the literature]. 157 32


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