Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mixed connective tissue disease (MCTD) was first reported 25 years ago. This report provides an assessment of the course of juvenile (J) MCTD in 224 patients available in the literature until 1996, including our own 33 patients. Most patients improved and remissions were observed in 3-5% (up to 27%). Among the long-term problems, a loss in joint function was seen in up to 29% of the cases, renal involvement in up to 47%, restrictive lung disease in up to 54% and gastrointestinal manifestations consisting of oesophageal dysmotility in up to 29%. Cerebral involvement was rare but severe. Cardiovascular problems observed include cardiomyopathy, myopericarditis and pulmonary hypertension. Among other long-term problems were Raynaud's phenomenon and scleroderma-like skin changes in up to 86% of the patients. Seventeen of the 224 patients had died (7.6%) because of sepsis or infection (7), cerebral complications (3), heart failure (2), pulmonary hypertension (2), renal failure (2) or gastrointestinal bleeding (1). The mortality rate of JMCTD seems to be in the same range as that of juvenile systemic lupus erythematosus, dermatomyositis and scleroderma. When compared with the other connective tissue diseases, however, mainly minor long-term problems are seen in the surviving patients.
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PMID:Course of mixed connective tissue disease in children. 945 80

The cardiovascular system is often involved during systemic lupus erythematosus (SLE), but only few studies have documented myocardial ischemia and myocardial infarction in young patients. We observed 2 cases of coronary artery disease in young patients with SLE and different clinical presentations. In the first case, a 26-year-old woman, with SLE diagnosed at the age of 12 years, was evaluated for angina (CCS class II). Myocardial scintigraphy revealed a clear reversible thallium-201 apical perfusion defect. During the following 5 years worsening effort angina led to coronary angiography which revealed the presence of a complete obstruction of the left anterior descending coronary artery (LAD) treated with surgical myocardial revascularization (internal mammary artery implantation on the LAD). The second patient had myopericarditis and an acute myocardial infarction 1 year before coming to our observation. Coronary angiography revealed the presence of 100% obstruction of the LAD. On this basis, a diagnosis of SLE was made. Our data constitute two relevant examples of coronary artery disease with different clinical presentation in young SLE patients.
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PMID:Coronary artery disease in young patients with systemic lupus erythematosus: two case reports. 1497 54

We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.
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PMID:Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C. 1852 29

Myocarditis and pericarditis are identified at autopsy in up to 50% of patients with systemic lupus erythematosus. However, clinical symptoms of heart failure are unusual, occurring in only 5%-7% of patients. Drug-induced lupus is rare and typically causes classic lupus symptoms of rash, fever, pleuritis, renal insufficiency, and arthritis. We present an unusual case of drug-induced lupus from chronic phenytoin use in a man who presented with symptoms of fulminant myopericarditis. To our knowledge, this is the first such case reported in English.
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PMID:Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus. 1893

Systemic lupus erythematosus (SLE) remains of unknown origin. Herpes viridae infections seem to play a role in the pathogenesis of this disease. We report a 31-year-old man who presented an acute cytomegalovirus (CMV) infection with persistent fever and myopericarditis as the presenting manifestation of SLE. This case report emphasizes a difficult differential diagnosis between SLE and an acute CMV infection and suggests a possible role of this virus in the pathogenesis of SLE.
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PMID:[Acute cytomegalovirus infection revealing systemic lupus erythematosus]. 2088 Jun 15

Recurrent pericarditis occur in around a quarter of patients after a first episode of acute pericarditis. Most of the cases are idiopathic or viral pericarditis or post-pericardial injury syndromes. Recurrent pericarditis are most likely to occur in patients with known systemic lupus erythematosus or rheumatoid arthritis but are rare in other systemic auto-immune diseases. We report here an unusual case of a patient with a 5-year history of four acute myopericarditis revealing Wegener's granulomatosis. Clinicians should consider the possibility of Wegener's granulomatosis in case of recurrent pericarditis and look for features suggestive of granulomatous disease affecting the upper and lower respiratory tract. In this setting, antineutrophil cytoplasmic autoantibodies (ANCA) testing and/or biopsy of involved organs appear of particular interest to confirm the diagnosis.
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PMID:[Recurrent pericarditis as an initial manifestation of Wegener's granulomatosis]. 2168 40

Myocardial involvement with clinical symptoms is a rare manifestation of systemic lupus erythematosus (SLE), despite the relatively high prevalence of myocarditis at autopsies of SLE patients. In this review, we report the case of a 19-year-old male SLE patient who initially presented with myopericarditis and was successfully treated with high dose of glucocorticoids.
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PMID:Myopericarditis in a korean young male with systemic lupus erythematosus. 2177 88

A 15-year-old African-American boy presented with unilateral decrease in vision following an episode of myopericarditis. His ocular examination was significant for diffuse retinal oedema and intraretinal haemorrhages. He was diagnosed with a central retinal vein occlusion and was referred to rheumatology for further evaluation following negative hypercoaguable studies. He was later found to have systemic lupus erythematous. Approximately 8 months after presentation, the patient's vision improved and remained stable at 20/40.
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PMID:Acute central retinal vein occlusion following episode of myopericarditis in an adolescent patient. 2390 77

We describe herein a 61-year-old African American woman who presented with takotsubo cardiomyopathy preceded by lupus myopericarditis. The case highlights the importance of the association between pericarditis and takotsubo cardiomyopathy. This new stressor adds to the existing evidence that these two entities may coexist and do not have to be mutually exclusive.
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PMID:Lupus myopericarditis as a preceding stressor for takotsubo cardiomyopathy. 2589 4

Myopericarditis with a pericardial effusion as the initial presenting feature of SLE is uncommon. We report an unusual case of myopericarditis and pericardial effusion with subsequent heart failure, as the initial manifestation of SLE. The timely recognition and early steroid administration are imperative in SLE-related myopericarditis with cardiomyopathy to prevent the mortality associated with this condition.
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PMID:Myopericarditis and Pericardial Effusion as the Initial Presentation of Systemic Lupus Erythematosus. 2826 Dec 71


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