Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024141 (
systemic lupus erythematosus
)
44,322
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A man in his 70s with known
systemic lupus erythematosus
(
SLE
) was admitted with confusion, worsening proteinuria and cutaneous vasculitis despite adherence to his home immunosuppressive regimen. Admission laboratories were consistent with active
lupus
. Despite treatment with pulse-dose glucocorticoids and intravenous immunoglobulin, he developed worsening mental status and meningeal signs. Investigations revealed cerebrospinal fluid (CSF) neutrophilic and plasmacytic pleocytosis and negative cultures. Empiric treatment for SLE flare with potential neuropsychiatric involvement was continued while workup for altered mental status was ongoing. Ultimately,
West Nile encephalitis
was diagnosed by CSF serologies, and steroids were tapered. Altered mental status in a patient with
SLE
has a broad differential, and primary neuropsychiatric
SLE
should be considered only after exclusion of secondary causes. Although evidence of end-organ
SLE
activity usually lends support to a neuropsychiatric
SLE
diagnosis, in this case, serological and clinical evidence of
SLE
activity may have been triggered by acute viral infection.
...
PMID:West Nile encephalitis mimicking neuropsychiatric lupus in a patient with systemic lupus erythematosus. 3134 30
