Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic interstitial cystitis (CIC) has been thought to result from autoimmune phenomena and its occurrence in systemic lupus erythematosus (SLE) has occasionally been recorded. We report a patient with SLE whose initial urinary symptoms were caused by CIC. Two of 3 patients (including ours) whose cases have been reported also had diarrhea, a common symptom in idiopathic CIC. All 3 patients had cutaneous and/or bladder vasculitis. CIC occurring in SLE seems to be due to immune complex deposition.
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PMID:Chronic interstitial cystitis as an initial major manifestation of systemic lupus erythematosus. 697 27

Chronic interstitial cystitis and ureteral stenosis has occasionally been reported in systemic lupus erythematosus, mostly associated with gastrointestinal symptoms. We report a case of obstructive uropathy associated to chronic interstitial cystitis as the only manifestation of lupus flare in a patient with SLE and anti-phospholipid syndrome (APS) who had been in remission for many years. The development of chronic interstitial cystitis in patients with SLE and APS has not been previously reported. Histopathological study of her urinary bladder and ureteral meatus showed chronic inflammatory infiltrate in the subepithelium. Lack of significant lower urinary tract symptoms and gastrointestinal involvement were some of the factors that could have prevented an earlier diagnosis. Obstructive uropathy and renal insufficiency initially improved with immunosuppressive treatment and endoureteral protheses, but poor compliance to the therapy led to ominous ending.
Lupus 2008 Jan
PMID:Obstructive uropathy as the only manifestation of flare in a patient with systemic lupus erythematosus and anti-phospholipid syndrome. 1808 83

A 20-year-old woman with systemic lupus erythematosus presented with dysuria, urinary frequency and suprapubic pain and was found to have a chronic interstitial cystitis, a chronic inflammation of the bladder wall, mostly affecting middle-aged women. Chronic interstitial cystitis is an uncommon manifestation of systemic lupus erythematosus.
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PMID:Interstitial cystitis and systemic lupus erythematosus in a 20-year-old woman. 1869 74