Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was conducted to analyze the prevalence and features of chronic or recurrent headache in Systemic Lupus Erythematosus (SLE), and also the relationship of such headache with other manifestations of the disease. A total of 76 patients (69 women and 7 men) with a mean age of 40 years (r: 24-74 years) were included. An overall severity index for SLE was applied. Fifty-two patients (68%) presented headache, 27 (52%) being vascular and 25 (48%) muscle contraction type. Headache in general was more frequent after the onset of SLE (p less than .001). Prevalence of muscle contraction headache in particular was greater following manifestations of SLE. Family history of migraine was recorded in 54% of the patients with vascular headache. This antecedent was more common in patients in whom migraine started before the onset of SLE (p = .05). A greater number of neuropsychiatric symptoms was observed in the patients with vascular headache and family history (p less than .02). Patients with thrombocytopenia presented headache less frequently (p less than .05). Our results showed headache, of both vascular and muscle contraction types, to be frequent in SLE. We note that there is an increased frequency of muscle contraction headache after the onset of SLE, and that there is a migraine-like headache directly related to SLE. Migrainous patients with familial history have a greater probability to suffer neuropsychiatric manifestations. Finally, it is suggested that severity of SLE is not related to presence of headache.
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PMID:A prospective study of chronic or recurrent headache in systemic lupus erythematosus. 233 79

This study was conducted to analyse the prevalence and features of headache in patients with SLE. 44 patients with SLE were reviewed retrospectively. The mean age of the patients was 43.8 +/- 11.5 years (r: 22-68), mean time of evolution of SLE was 11.8 +/- 9.0 years (r: 1-30). 28 patients (27 woman and 1 man) had clinical evidence of central nervous system involvement, 18 patients (40.9%) had headache; 6 (33.4%) being vascular, 3 (16.7%) migraine, 9 (50%) muscle contraction headache. In 4 patients headache started before the other signs or symptoms of SLE, in 8 patients headache appeared in the first year of the disease. In the patients with headache other manifestations of nervous system involvement were present very often. Most patients had more than one symptom or sign during the course of the illness. The results of our examination showed that headache is frequent in the course of SLE and probably it is connected with vascular lesion of the nervous system. We failed to find a relationship between headache and other manifestations of SLE and the treatment of SLE.
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PMID:[Headache in systemic lupus erythematosus]. 1110 80