Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 50 year old woman presented with pneumococcal septicaemia, septic arthritis, and a lobar pneumonia and was subsequently diagnosed as having systemic lupus erythematosus. The blood film and splenic 99mTc sulphur colloid uptake were normal, although selective functional hyposplenism was shown by the impaired clearance of immunoglobulin coated erythrocytes. Systemic lupus erythematosus presenting with fulminating pneumococcal sepsis in the presence of selective defects in spleen function is previously unreported.
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PMID:Systemic lupus erythematosus presenting as pneumococcal septicaemia and septic arthritis. 232 28

Fatal pneumococcal sepsis due to functional asplenia in a child with systemic lupus erythematosus (SLE) and transient hyposplenism in a 2nd child during an acute flare of SLE are described. Splenic ultrasound examinations and radionuclide spleen scans in 11 other children with SLE were normal. Splenic atrophy and dysfunction is an uncommon but potentially fatal complication of SLE in childhood.
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PMID:Functional asplenia in childhood onset systemic lupus erythematosus. 307 28

Splenic function as measured by number of vacuolated red blood cells (RBC) seen with phase contrast microscopy was studied in 44 patients with systemic lupus erythematosus (SLE). Two of 44 patients (4.6%) had increased percentages of vacuolated RBC (8.4% and 30.6%) indicative of hyposplenism. Both patients had inactive disease at the time, were on low doses of corticosteroids, and had persistence of vacuolated RBC when restudied 2 and 4 months later. The present study confirms the association of hyposplenism with SLE and indicates that the incidence of hyposplenism in SLE is about 5%.
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PMID:Hyposplenism in systemic lupus erythematosus. 634 71

Reticuloendothelial function was assessed in 11 patients with systemic lupus erythematosus, 8 patients with Wegener's granulomatosus, and 20 patients with idiopathic membranous glomerulopathy by using autologous 99mTc-labeled heat-damaged red blood cells. With this method organ uptake could be measured by quantitative scintigraphy. There was no relation between the T1/2 of the blood disappearance curve and the T1/2 of the splenic uptake curve. The T1/2 of the blood disappearance curve was normal in all three patient groups. However, there was a significant shift from spleen to liver uptake in patients with active systemic lupus erythematosus, active Wegener's granulomatosus, and membranous glomerulopathy in comparison with a control group. There was no relation with age, level of circulating immune complexes, complement level, kidney function, or immunosuppressive treatment. We conclude that an increase of the liver component of reticulo-endothelial function may compensate abnormalities in splenic function. This stresses the importance of quantitative scanning to detect such abnormalities. The study provides evidence for disease related hyposplenism in patients with active systemic lupus erythematosus, active Wegener's granulomatosus, and membranous glomerulopathy.
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PMID:Abnormal reticuloendothelial function in patients with active vasculitis and idiopathic membranous glomerulopathy. A study with 99mTc-labeled heat-damaged autologous red blood cells. 684 Jan 27

Hyposplenism, which is suggested by a typical peripheral blood smear and by the absence of splenic activity in a 99m Tc sulphur colloid scan, has been recently found to be associated with various diseases. This condition increases the susceptibility of patients to certain bacterial infections principally by pneumococci, meningococci and Haemophilus influenzae. The association of SLE and hyposplenism has not often been reported before; thus we see fit to report another such case. The administration of polyvalent pneumococcal vaccine is recommended in this condition.
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PMID:Hyposplenism in systemic lupus erythematosus. 687 86

Five of 70 patients with systemic lupus erythematosus seen over a 5-year period had peripheral blood films suggestive of hyposplenism. Technetium-99m-sulfur colloid scans showed no splenic activity in three patients. One of these three patients, who had a spontaneous remission of persistent thrombocytopenia concurrent with the appearance of functional asplenia, had splenic atrophy shown by computed tomography; a second patient, who died of pneumococcal septicemia, was shown to have splenic atrophy with lymphocyte depletion at autopsy. The development of functional asplenia in the third patient has now, to date, had any obvious effect on her disease. In the two patients with normal scans, blood film findings returned to normal with treatment of the underlying disease. Polyvalent pneumococcal vaccine is recommended for patients with lupus erythematosus who have splenic atrophy.
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PMID:Splenic atrophy in systemic lupus erythematosus. 705

Salmonellosis was diagnosed in 4 patients with systemic lupus erythematosus (SLE). Three patients were taking prednisolone, and 3 had evidence of nephritis. All patients were febrile with clinical evidence of lupus activity at the time of diagnosis. Two patients had evidence of hyposplenism during the infection. Because salmonellosis manifests clinical symptoms like those of active SLE, the diagnosis of the salmonella infection was delayed. In 3 patients, the salmonella infection localized to a site of clinical SLE involvement and in all 4 patients, it occurred simultaneously with other bacterial infections. Multiple factors, including impaired mononuclear phagocytic system function, may predispose SLE patients to bacterial infections, especially intracellular parasites such as salmonella.
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PMID:Concurrent systemic lupus erythematosus and salmonellosis. 729 62

During the course of systemic lupus erythematosus in a young female patient the peripheral blood smear incidentally showed the features of hyposplenism. Silent lupus vasculitis with splenic infarction was suspected as the cause of this.
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PMID:Hyposplenia in a patient with systemic lupus erythematosus. 737 21

Although functional hyposplenism, secondary to Fc-receptor blockage by circulating immune complexes saturation, has been described in systemic lupus erythematosus (SLE), only few cases of complete asplenism have been reported. We observed a 60-year-old woman with congenital asplenism who presented with active SLE. The course and the clinical characteristics of such patients are reviewed and the relationship between the asplenic state and initiation and severity of SLE are discussed. These patients are at high risk for fatal pneumococcemia and pneumococcal vaccine is recommended even if long term results are still conflicting.
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PMID:Asplenism and systemic lupus erythematosus. 778 66

Systemic lupus erythematosus is a relatively common autoimmune disease in the United States. Hyposplenism is infrequently described in patients with systemic lupus erythematosus. It is seen in up to 5% of patients and is thought to be caused by vasculitic changes within the spleen. The diagnosis of hyposplenism can be made easily by identifying Howell-Jolly bodies on a peripheral blood smear. The authors describe a patient with systemic lupus erythematosus associated with hyposplenism and discuss possible diagnostic and treatment implications.
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PMID:Splenic hypofunction in systemic lupus erythematosus. 805 31


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