Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Calcinosis universalis is an unusual complication of systemic lupus erythematosis (SLE). We describe the case of a 22-year-old patient diagnosed with SLE during childhood, who developed a previously unreported complication of parotid calcification. Medical treatment of calcinosis is often ineffective, whereas surgical intervention completely relieved the patient's symptoms.
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PMID:Parotid calcification in systemic lupus erythematosis. 1243 47

Calcinosis cutis is a deposition of calcium salts in the skin and subcutaneous tissue which can occur in connective tissue diseases such as scleroderma, dermatomyositis, myositis and overlap syndrome, but rarely in association with systemic lupus erythematosus (SLE). It is subdivided into a localized 'circumscripta' and diffuse 'universalis'. The few reported cases of calcinosis in SLE were mainly of the circumscripta type. Calcinosis universalis is extremely rare and is usually associated with a history of chronic active SLE in female patients, with few proven effective treatments. We report a case of a young female patient with a long and complicated history of SLE. She presented with widespread pain and tenderness associated with multiple subcutaneous skin lesions. She was found to have evidence of calcinosis universalis on X-rays. Investigations did not reveal any associated conditions that could explain this diagnosis other than her prolonged history of SLE.
Lupus 2020 Oct
PMID:Calcinosis cutis universalis in a patient with systemic lupus erythematosus: a case report. 3269 83