Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Libman-Sacks endocarditis is a well-described clinical entity in patients with systemic lupus erythematosus. Transesophageal echocardiography is the definitive imaging modality used in assessing cardiac valvular involvement in this disease process. Herein we describe a young Hispanic woman with systemic lupus erythematosus and multiple tricuspid valvular vegetations who developed splenic and cerebral infarctions while on optimal anticoagulation therapy with warfarin in the setting of a newly diagnosed patent foramen ovale. A review of the literature on Libman-Sacks endocarditis and patent foramen ovale closure is presented.
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PMID:A 38-year-old Hispanic woman with paradoxical embolism and Libman-Sacks endocarditis involving the tricuspid valve. 1760 Jun 75

In antiphospholipid syndrome (APS), there is a high prevalence of valvular heart disease which leads to increased risk of thrombo-embolic events, in particular, cerebrovascular events. We present a patient with cerebral infarction, previous deep-vein thrombosis, and miscarriages with positive lupus anticoagulant and anticardiolipin antibodies. Echocardiographic examination revealed mitral valve leaflet thickening and verrucous vegetations consistent with Libman-Sacks endocarditis, which is commonly associated with APS. In patients with combined Libman-Sacks endocarditis and antiphospholipid antibodies, anticoagulation therapy with warfarin is indicated due to high risk of valvular thrombus formation and subsequent embolization.
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PMID:Libman-Sacks endocarditis and cerebral embolization in antiphospholipid syndrome. 1826 21

The perforation of a mitral valve aneurysm is a rare disease which induces acute mitral regurgitation and is usually induced by infective endocarditis; however, in this case report, acute heart failure was caused by a perforated mitral valve aneurysm that was speculated to be due to Libman-Sacks endocarditis with systemic lupus erythematosis and secondary anti-phospholipid syndrome. Mitral valve plasty was performed and thereafter heart failure improved.
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PMID:Perforated mitral valve aneurysm associated with Libman-Sacks endocarditis. 1879 20

A 21-year-old Hispanic woman presented with a history of spontaneous miscarriage developed palpable purpura and transient visual loss followed by permanent vision loss OD, secondary to a central retinal artery occlusion with concomitant optic disk edema. The differential diagnosis for vascular occlusion in systemic lupus erythematosus includes antiphospholipid antibody, systemic lupus erythematosus-related vasculitis, hypercoaguable state, or Libman-Sachs endocarditis.
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PMID:Getting to the heart of the matter. 1902 23

Systemic lupus erythromatosus is often associated with an antiphospholipid syndrome (APS). A high prevalence of valvular heart disease in APS leads to increased risk of embolic events, particularly cerebrovascular. We present a patient with cerebral infarction, with positive lupus anticoagulant, anticardiolipin antibodies and factor V Leiden mutation. Echocardiographic examination revealed mitral valve anterior leaflet thickening and verrucous vegetations consistent with Libman-Sacks endocarditis, which is commonly associated with APS.
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PMID:[Recurrent multi-focal cerebral stroke complicating Libman-Sacks endocarditis in a young woman with systemic lupus erythromatosus]. 1925 90

Cardiac involvement is a recognized complication of systemic lupus erythematosus (SLE), which can involve most cardiac components, including pericardium, conduction system, myocardium, heart valves, and coronaries. Libman-Sacks (verrucous) endocarditis is the characteristic cardiac valvular manifestation. We report a patient with SLE who had severe aortic regurgitation caused by Libman-Sacks endocarditis. The patient underwent successful mechanical aortic valve replacement.
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PMID:Aortic valve replacement for Libman-Sacks endocarditis. 1963 41

Libman-Sacks endocarditis is the most common cardiac manifestation in patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (PAPS); it is characterized by Libman-Sacks vegetations, valve thickening or fibrosis, valve regurgitation, and rarely valve stenosis. It is most commonly clinically manifested with cardioembolism (predominantly to the brain), uncommonly with symptomatic severe valve regurgitation, or rarely with over imposed infective endocarditis. These three clinical syndromes are associated with a five to eight times higher morbidity and mortality than in a general population. Libman-Sacks endocarditis is infrequently detected by the history and cardiovascular physical examination; it is detected by transthoracic echocardiography (TTE) in 30-40% as compared to 60-80% of patients by transesophageal echocardiography (TEE). Also, TTE as compared to TEE has low sensitivity (63% overall, 11% for valve vegetations), low specificity (58%), low negative predictive value (40%), and a moderate positive predictive value (78%) for the detection of Libman-Sacks endocarditis. In addition, TEE has played a major role in our current understanding of the specific characteristics, evolution, assessment of prognosis, and defining the need and response to medical or surgical therapy of Libman-Sacks endocarditis. Therefore, an increased awareness of the potential clinical complications of Libman-Sacks endocarditis and application of echocardiography, especially of TEE, may lead to an earlier and accurate diagnosis, guidance of therapy, prevention of complications, decreased rate of progression of the disease, and consequently to an event free survival of patients with SLE or PAPS.
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PMID:Diagnostic value of transesophageal echocardiography in Libman-Sacks endocarditis. 1976 69

Libman-Sacks endocarditis, characterized by sterile fibrofibrinous vegetations that have the potential to develop anywhere on the endocardial surface, was originally reported in 1924. The mitral valve is most commonly affected, followed by the aortic valve, whereas tricuspid and pulmonary valves are seldom involved. Libman-Sacks vegetations can be found in approximately 1 of 10 patients with systemic lupus erythematosus by transoesophageal echocardiography (TTE), and they are variably associated with lupus duration, disease activity, anticardiolipin antibodies, and antiphospholipid syndrome manifestations. The capability to perform real-time 3D (RT3D) imaging in the evaluation of Libman-Sacks vegetation size may strengthen the already established role of transthoracic echocardiogram and TTE. The exact estimation of vegetation size may influence therapeutic interventions. Therefore, we are trying to highlight the role of RT3D echocardiography in assessing vegetation size in a patient with Libman-Sacks endocarditis.
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PMID:Real-time three-dimensional echocardiography in evaluating Libman-Sacks vegetations. 1994 16

Libman-Sacks endocarditis of the mitral valve was first described by Libman and Sacks in 1924. Currently, the sterile verrucous vegetative lesions seen in Libman-Sacks endocarditis are regarded as a cardiac manifestation of both systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). Although typically mild and asymptomatic, complications of Libman-Sacks endocarditis may include superimposed bacterial endocarditis, thromboembolic events, and severe valvular regurgitation and/or stenosis requiring surgery. In this study we report two cases of mitral valve repair and two cases of mitral valve replacement for mitral regurgitation (MR) caused by Libman-Sacks endocarditis. In addition, we provide a systematic review of the English literature on mitral valve surgery for MR caused by Libman-Sacks endocarditis. This report shows that mitral valve repair is feasible and effective in young patients with relatively stable SLE and/or APS and only localized mitral valve abnormalities caused by Libman-Sacks endocarditis. Both clinical and echocardiographic follow-up after repair show excellent mid- and long-term results.
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PMID:Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature. 2033 96

In 1924, Libman and Sacks described valvular lesions in patients with lupus erythematosus. Libman-Sacks valvular lesions are sterile fibrinous vegetations that preferentially develop at the left-sided heart valves. Reports of their prevalence range from 53 to 74%. Libman-Sacks endocarditis is associated with disease activity and antiphospholipid antibodies titer. Echocardiography is a useful tool for documenting valvular involvement and dysfunction as well as disease progression. Transesophageal echocardiography is superior to transthoracic echocardiography in detecting Libman-Sacks endocarditis. This report describes the echocardiographic image of Libman-Sacks endocarditis in a patient with active lupus erithematosus.
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PMID:[Libman-Sacks endocarditis]. 2042 38


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