Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pulmonary vasculitis occurs most commonly in the collagen vascular diseases and in granulomatous pulmonary disease. In the collagen vascular group, vasculitis causes diffuse interstitial inflammation and subsequent fibrosis, resulting in interstitial radiographic patterns, especially in the lower lung fields. Vasculitis accompanied by granulomatosis typically produces focal inflammation and is, therefore, manifested as nodules and masses. The more typical collagen vascular diseases include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. The most common vasculitis granulomatosis is Wegener's, with similar radiographic abnormalities occurring in lymphomatoid granulomatosis. Atypical examples of vasculitis pulmonary disease include ankylosing spondylitis, in which upper-lung field fibrobullous changes are seen. Periarteritis nodosa and Behcet's syndrome include abnormalities of large vessels and thromboembolic phenomena. Bronchocentric granulomatosis and allergic granulomatosis involve airway abnormalities as well as vasculitis and granuloma formation.
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PMID:Vasculitis in the lung. 289 60

Pulmonary vasculitis is an uncommon complication of systemic lupus erythematosus (SLE), and has not been previously documented in pregnancy. This case report describes the rapidly fatal course of a pregnant SLE patient, whose terminal illness was manifested by severe pulmonary hypertension and unexpected autopsy findings of medium and large vessel vasculitis. The relationship of these unusual manifestations to other clinical and serologic features of SLE, as well as novel therapeutic options, are discussed.
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PMID:A fatal pulmonary complication of lupus in pregnancy. 884 93