Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have reviewed 275 patients who were tested in the light testing clinic in the 10 years from 1972 to 1981. 151 patients (55%) were referred with eczematous changes of the skin attributed to light, while 76 (28%) had a history of polymorphic light eruption. Light tests gave abnormal results in 54 (36%) of the dermatitis group, showing a photoallergy in 17 patients and UV sensitivity with or without sensitivity to visible light in 30 patients. 7 out of 10 cases with clinical reactions to phenothiazines also had abnormal test results. Patients with polymorphic light eruption reacted normally in our test system. Abnormal tests were obtained in solar urticaria, in a few cases of non-eczematous phototoxic reactions, folliculitis of the acne type and systemic lupus erythematosus. Additional patch tests with standard allergens revealed a high % of contact sensitivity in the 30 UV sensitive patients.
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PMID:Skin testing with simple equipment in photodermatoses. 717 51

To know the clinical characteristics of male patients with systemic lupus erythema(SLE), the clinical and laboratory indications of 46 male SLE patients were analysed and compared with those of 269 females. The results showed that: 1. There was family history in 21.28% of male patients. 2. As compared with female SLE patients, pleurisy, pericarditis, lupus nephritis(LN), proteinuria, renal failure, the incidence of types, V-LN and the positive rate of Sm antibody were more common in males while facial erythema, Raynaud's phenomenon and photoallergy were less in male. There were statistical differences between the male and female. 3. The confirmed diagnosis for the male SLE was delayed. The recovery rate was lower and the mortality was higher in males. These findings suggest that evident genetic predisposition, atypical clinical manifestations, serious renal injury and the worse prognosis are the characteristics of male SLE.
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PMID:[A clinical study on male patients with systemic lupus erythema]. 1221 33

Benzophenones are common causes of photoallergy and are increasingly used in products other than traditional sunscreens. Patients may be unaware of any sunscreen exposure when using a product such as shampoo containing benzophenone. Benzophenones also may produce photoallergic contact urticaria, in addition to delayed contact and photocontact dermatitis, which may complicate the clinical presentation. Allergy to benzophenone should be considered in the diagnosis of patients with patchy erythema of the face and neck that is not typically eczematous and that may otherwise be attributed to a rosacea diathesis, lupus erythematosis, or simple flushing. Patch and photopatch testing are indicated to evaluate these patients for allergy to benzophenone.
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PMID:Facial erythema as a result of benzophenone allergy. 1457 46