Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of central retinal vein occlusion with second development of the same type of retinal vein occlusion in the fellow eye, is reported. The patient was a 68 year-old man with a history of thyroid gland disorder and a cardiac arrhythmia. He presented also with bilateral tilted disc. The first eye occlusion was initially nonischemic, but converted secondarily into an ischemic type and required laser panretinal photocoagulation. The biological assay found the presence of lupus anticoagulant antibodies and rheological findings (major plasma hyperviscosity, increased erythrocyte aggregation, high hematocrit and fibrinogen levels). The patient was given high doses of troxerutin, and aspirin. Central retinal vein occlusion occurred in the fellow eye one year later, a few weeks after the decrease of troxerutin doses. Hemodilution therapy was performed and visual acuity remained unchanged. Unusual risk factors for retinal vein occlusion are discussed. Lupus anticoagulant antibodies may sometimes lead to occlusive vascular phenomenon. Although these antibodies are not commonly found in retinal vascular occlusion, they may constitute a contributory factor. Tilted disc has often been involved in the pathogenesis of central retinal vein occlusion. Finally, abnormal rheological findings, major in this case, are found in more than half of the cases of retinal vein occlusion.
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PMID:[Bilateral central retinal vein occlusion and circulating anticoagulant]. 756 Jul 89

Central retinal vein occlusion (CRVO) is frequent in patients with systemic lupus erythematosus (SLE), but the treatment of the macular edema with this disease is extremely difficult. We report a case of cystoid macular edema (CME) secondary to unilateral CRVO in a patient with SLE that responded to intravitreous injection of an anti-vascular endothelial growth factor (VEGF) agent. A 33-year-old Japanese woman was referred to our department with unilateral impairment of vision. Microperimetry (MP-1) showed a cessation of foveal sensitivity. Fluorescein angiography showed CME without ischaemia of the macular region or peripheral retina (nonischemic CRVO). A diagnosis of CME and unilateral nonischemic CRVO combined with SLE was made and intravitreous anti-VEGF therapy was given. A sample of aqueous humor was harvested at the start of intravitreous injection after obtaining informed consent. Then the levels of VEGF and monocyte chemotactic protein (MCP)-1 were measured in the aqueous humor by enzyme-linked immunosorbent assay, revealing that VEGF was 234 pg/mL and MCP-1 was 501 pg/mL. Two weeks later, left eye vision improved to 20/20. Optical coherence tomography (OCT) showed considerable amelioration of retinal swelling and CME. MP-1 showed a marked increase of foveal sensitivity. However, she had recurrence of edema 3 months later. After harvesting aqueous humor again, intravitreous injection of an anti-VEGF agent was repeated for CME. The aqueous VEGF and MCP-1 levels were 156 pg/mL and 360 pg/mL, respectively. These findings suggest that inflammation was improved by intravitreous injection of bevacizumab. Intravitreous injection of anti-VEGF agents may be effective for CME due to nonischemic CRVO in SLE patients if their inflammatory factor levels are low.
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PMID:Unilateral macular edema with central retinal vein occlusion in systemic lupus erythematosus: a case report. 2369 Jun 76

Retinal vascular occlusion is the most common cause of retinopathy leading to severe visual loss in all age groups. Central retinal vein occlusion (CRVO) is usually seen in older age group and is often associated with systemic vascular diseases. Although the exact cause and effect relationship has not been proven, central retinal vein occlusion has been associated with various systemic pathological conditions, hence a direct review of systems toward the various systemic and local factors predisposing the central retinal vein occlusion is advocated. We describe the development of central retinal venous occlusion with associated cystoid macular edema (CME) in two healthy infertile women who were recruited for in vitro fertilization cycle for infertility. Predisposing risk factors associated with central retinal vein occlusion are obesity, sedentary life style, smoking, and some systemic diseases such as hyperlipidemia, hypertension, associated autoimmune disorders e.g., antiphospholipid antibody syndrome, lupus, diabetes mellitus, cardiovascular disorders, bleeding or clotting disorders, vasculitis, closed-head trauma, alcohol consumption, primary open-angle glaucoma or angle-closure glaucoma. In our patients, they were ruled out afterdoing allpertaining investigations. The cases were managed with further avoidance of oral contraceptives and intra-vitreal injections of Bevacizumab (Avastin), an anti-vascular endothelial growth factor (anti-VEGF drug) and Triamcinolone acetonide (a long acting synthetic steroid). Hence, even if no systemic diseases are detected. Physical examinations are recommended periodically for young women on oral contraceptive pills.
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PMID:Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. 2386 59