Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper describes a case of osteomyelitis due to Salmonella bovis morbificans in a patient with systemic lupus erythematosus (SLE) on long-term corticosteroid therapy. Although the organism was susceptible in vitro to chloramphenicol, ampicillin and co-trimoxazole, therapy with any of these drugs became impossible due to severe allergic reactions. A prolonged course of trimethoprim coupled with surgical debridement cured the lesion. The serum concentration of trimethoprim 24 hours after administration of a single oral dose of 300 mg was over four times the minimum inhibitory concentration (MIC) of the Salmonella sp. involved. These results indicate that trimethoprim may be effective in the treatment of Salmonella osteomyelitis.
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PMID:Salmonella osteomyelitis in a patient with systemic lupus erythematosus. 650 98

Hematogenous Salmonella osteomyelitis is uncommon in immunocompetent hosts, but occurs with some regularity in immunosuppressed patients affected by systemic lupus erythematosus (SLE). Surgical debridement with resection of compromised tissue is central to the surgical management of osteomyelitis. Persistence of septic arthropathy may result from inadequate debridement, areas of osteonecrosis (ON), and an abnormal cellular and humoral dysregulation characteristic of SLE. We describe a 53-year-old Hispanic female with SLE on immunosuppressive therapy, who developed acute salmonella-induced septic arthritis and osteomyelitis of both knees associated with ON and recurrent SLE synovitis. She received prolonged antibiotic therapy and an extensive surgical debridement as part of a successful two-stage bilateral total knee replacement. This report illustrates the significance of Salmonella enterica infection in SLE patients, and the role of underlying bone and joint pathology such as bone infarcts, sub-acute osteomyelitis, and SLE synovitis.
Lupus 2013 Jun
PMID:Salmonella septic arthritis of the knees in a patient with systemic lupus erythematosus. 2375 1