Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infection with opportunistic organisms, either singly or in combination, is known to occur in immunocompromised patients. A patient with systemic lupus erythematosus who developed Pneumocystis carinii pneumonia, cytomegalovirus pneumonitis, and salmonellosis is reported. She responded to early treatment with intravenous trimethoprim-sulphamethoxazole (20 mg/kg).
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PMID:Coexisting Pneumocystis carinii pneumonia, cytomegalovirus pneumonitis and salmonellosis in systemic lupus erythematosus. 166 29

A retrospective review was undertaken of zoonotic Salmonella infections among 173 patients with systemic lupus erythematosus (SLE) who were followed by two departments of rheumatology in Copenhagen during an average period of 16 years. A total of six Salmonella infections were registered in five patients as one patient had two episodes of infection with Salmonella typhimurium with an interval of three years. All six infections were diagnosed during the years 1986-1990. During the period 1984 to 1988, the number of registered Salmonella infections increased from 900 to 3,500 in the Danish background population. All six infections were accompanied by Salmonella bacteraemia. the present investigation and studies of the literature demonstrate a considerably increased risk of Salmonella bacteraemia in SLE patients as compared with the population as a whole. This should be borne in mind when febrile SLE patients are investigated.
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PMID:[Salmonella infections in patients with systemic lupus erythematosus]. 194 89

Despite the high frequency of both pericardial involvement and of infectious complications in SLE, septic pericarditis is uncommon. We report here a patient with SLE who developed tamponade due to Salmonella infection. Most of the other eight recorded cases of septic pericarditis in SLE were due to Staphylococcus aureus and none has been previously attributed to Gram-negative bacteria.
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PMID:Salmonella pericarditis with tamponade in systemic lupus erythematosus. 240 7

The Widal test was performed on 90 blood specimens from typhoid fever patients, on 21 blood specimens from nontyphoid salmonellosis patients and on 46 nontyphoid febrile patients. Of 90 typhoid fever patients, 58 (64.4%) had H agglutinin titer of 1:160 or more and 55 (61.1%) had O agglutinin titer of 1:160 or more. Salmonella typhi H and/or O titer of 1:160 or more occurred in 70 (77.8%) of 90 typhoid fever patients and in 5 (23.8%) of 21 nontyphoid salmonellosis. Only one of the 46 (2.2%) nontyphoid febrile patients showed O agglutinin titer of 1:160, a case which was proven subsequently to be a case of systemic lupus erythematosus. Either O or H can reach to diagnostic level during the first week of typhoid fever, and can be helpful in diagnosis of the illness. In view of the high specificity (91.0%), sensitivity (77.8%) and accuracy (83.4%), the Widal test still has value in the diagnosis of typhoid fever.
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PMID:Diagnostic value of a single Widal test. 241 86

Patients with systemic lupus erythematosus (SLE) are at increased risk for infections. Insufficiency of the reticuloendothelial system caused either by immunosuppressive therapy or inadequate opsonisation are mechanisms by which Salmonella infections in particular appear in these patients. Salmonella infections can provoke a polyarticular reactive arthritis while Salmonella bacterial arthritis usually is monarticular. We report on the seriousness of a Salmonella infection (enteritis complicated by polyarticular bacterial arthritis) in a patient with SLE.
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PMID:Polyarticular Salmonella bacterial arthritis in a patient with systemic lupus erythematosus. 266 66

Non-endemic Salmonella bacteremia tends to occur in patients with chronic disease. We reviewed all cases of Salmonella infection documented in adults at Bellevue Hospital during the years 1975-1982. Unexpectedly, the most frequent underlying disease found among bacteremic patients was systemic lupus erythematosus (SLE). Patients with SLE accounted for 6 of 30 Salmonella bacteremias as compared with 13 of 2,388 non-Salmonella gram-negative bacteremias. Salmonella was the single most frequent gram-negative isolate from the blood of SLE patients. All lupus patients with Salmonella infection were bacteremic. In contrast, isolates from blood represented only 23% of all Salmonella infections documented in the non-lupus population. Presentation was characterized by fever (greater than 103 degrees F) and abdominal pain. Four of the 6 patients were hypocomplementemic. All were receiving immunosuppressive therapy. We conclude that SLE patients in a municipal hospital setting are at increased risk for Salmonella sepsis. This should be considered when empiric antibiotic therapy is initiated.
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PMID:Salmonella bacteremia in systemic lupus erythematosus. Eight-year experience at a municipal hospital. 388 Nov 3

The salmonella group of bacteria consists of at least 1700 subtypes and causes widespread gastroenteric disease throughout the world, there being approximately two million cases yearly in the United States alone. An uncommon but interesting complication is the hematogenous lodgment of organisms in other sites of the body with resultant localized abscess formation, often months or years later. We present a review of 15 cases seen in our affiliated hospitals over a nine-year period. Remote salmonellosis most often occurs in patients with underlying systemic disease, such as lupus, malignancy, diabetes, and sickle cell disease, or in association with therapy that suppresses host resistance including steroids and cancer chemotherapy. The most frequent sites of involvement are bone marrow, joints, meninges, pleura, and blood vessels, or in an area of locus minoris resistentiae. The latter include scars, hematomas, fracture sites, prosthetic devices, and neoplasms. Our experience would suggest that these infections, which can remote both in location and time from the original gastrointestinal episode, are perhaps more frequent today than is generally realized. Diagnosis is often delayed because of lack of familiarity with this entity. Treatment consist of either drainage or excision of infected tissue often combined with long-term antibiotics.
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PMID:Remote salmonellosis: surgical masquerader. 707 24

Salmonellosis was diagnosed in 4 patients with systemic lupus erythematosus (SLE). Three patients were taking prednisolone, and 3 had evidence of nephritis. All patients were febrile with clinical evidence of lupus activity at the time of diagnosis. Two patients had evidence of hyposplenism during the infection. Because salmonellosis manifests clinical symptoms like those of active SLE, the diagnosis of the salmonella infection was delayed. In 3 patients, the salmonella infection localized to a site of clinical SLE involvement and in all 4 patients, it occurred simultaneously with other bacterial infections. Multiple factors, including impaired mononuclear phagocytic system function, may predispose SLE patients to bacterial infections, especially intracellular parasites such as salmonella.
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PMID:Concurrent systemic lupus erythematosus and salmonellosis. 729 62

Infections in systemic lupus erythematosus are frequent. However, osteoarticular Salmonella infections are rarely reported. We report a case of systemic lupus erythematosus diagnosed in a 15 year-old girl. Seven months later, she presented with fever and a localized collection of the upper extremity of the left tibia related to a Salmonella enteritidis acute osteomyelitis (sub periosteal abscess). The out-come was chronic and led to death. The authors emphasize the severity of non typhoidal salmonellosis in systemic lupus erythematosus.
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PMID:[Systemic lupus erythematosus and Salmonella enteritidis osteomyelitis]. 748 Nov 56

We report the case of a 74-year-old woman with long-standing systemic lupus erythematosus (SLE) who developed Salmonella septicaemia and an aortic mycotic aneurysm which proved fatal. She had received only low dose prednisolone (average 5-10 mg) as treatment for her disease, which appeared to be inactive at the time of her presentation with septicaemia. This is the first case report of this particular manifestation of salmonellosis in SLE and the patient died despite standard antibiotic treatment. This case emphasizes the need for continued vigilance for signs of Salmonella infection when managing patients with SLE.
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PMID:Fatal salmonellosis in systemic lupus erythematosus. 767 27


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