Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a 35-year-old man with systemic lupus erythematosus and an associated protein-losing enteropathy that was most likely due to mesenteric venulitis or thrombosis. Evaluation of the patient's intestinal abnormality was aided by the use of magnifying endoscopy; the duodenal villi were lustrous and swollen and of various size, a pattern different from that previously described for intestinal lymphangiectasia. The patient was treated with corticosteroids, resulting in a good clinical response and return of the villi to normal shape and size.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. Observations by magnifying endoscopy. 268 13

Enteric protein loss resulting in profound hypoalbuminemia and anasarca is an uncommon manifestation of systemic lupus erythematosus and only rarely is the initial presentation of disease. A few patients with SLE and protein-losing enteropathy in the absence of increased central venous pressure or intestinal lymphangiectasia have been reported. We describe the utility alpha-1-antitrypsin clearance in stool for diagnosing and monitoring enteric protein loss during successful immunosuppressive drug therapy in a patient who presented with massive enteric protein loss as the initial manifestation of systemic lupus erythematosus.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. Diagnosis and monitoring immunosuppressive therapy by alpha-1-antitrypsin clearance in stool. 278 7

Protein-loss into the gastrointestinal tract is a feature of many different diseases, a number of which are immunologically mediated, e.g. systemic lupus erythematosus or Crohn's disease. The pathogenic mechanism of protein-losing enteropathy in diseases without obvious enterocyte injury are unknown. Brown-Norway-rats (BN-rats) were gavaged with low doses of HgCl2 for 39 weeks. Within 2 weeks, the intestines showed strong linear staining for IgG and IgA along vascular and intestinal basement membranes. Granular deposits containing IgG and C3 were present along intestinal basement membrane only in the late stages of the experiment; only in these animals increased intestinal protein loss as measured by fecal Cr-51 excretion was found. These findings suggest that immune complex deposition along the intestinal basement membrane can lead to protein-losing enteropathy. This disease may be used as a model for the study of immunologically mediated intestinal disease.
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PMID:[Mercuric chloride-induced enteropathy in the rat: a model of gastrointestinal disease with immunologic pathogenesis]. 296 59

Two patients with systemic lupus erythematosus (SLE) presented with anasarca, pleural effusions and severe hypoalbuminema. Both were demonstrated to have protein-losing enteropathy, a rare complication of SLE. Other causes of gastrointestinal protein loss were excluded. There were marked similarities in both cases including circulating ANF with speckled staining, anti-(U1)RNP antibodies and low serum complement levels. Complete remission was achieved in both with prednisolone. Anti-(U1)RNP may be a marker for a subset of SLE in which protein-losing enteropathy is a major manifestation.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. 307 59

A case of a person with a mixed connective-tissue disease, who subsequently developed protein-losing enteropathy with a partial response to prednisolone therapy, is presented. Protein-losing enteropathy has been reported in several patients with systemic lupus erythematosus but not in patients with mixed connective-tissue disease. This case broadens the association of protein-losing enteropathy with autoimmune diseases and suggests that the diagnosis should be considered in patients with mixed connective-tissue disease who have hypoalbuminaemia.
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PMID:Protein-losing enteropathy and mixed connective-tissue disease. 318 26

A 33-year-old woman presented a recurrent steroid-sensitive protein-losing enteropathy as the major manifestation of systemic lupus erythematosus. An increased capillary permeability for proteins is considered to be the most likely explanation.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. 400 95

Although protein-losing enteropathy can be associated with a variety of disorders, only three cases have been described in association with systemic lupus erythematosus. In the case described herein, protein-losing enteropathy was the only clinical manifestation of systemic lupus erythematosus. Small intestinal biopsy revealed edema and mild mononuclear cell infiltration in lamina propria mucosae and no evidence of lymphangiectasia. X-ray studies of the gastrointestinal tract were normal. Protein-losing enteropathy responded to high-dose corticosteroid therapy. Protein-losing enteropathy should be suspected as a possible cause of unexplained hypoalbuminemia in systemic lupus erythematosus.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. 682 33

A 22-yr-old woman with a 7-yr history of systemic lupus erythematosus presented with anasarca and a serum albumin of 0.8 g/dl. Renal and hepatic function were near normal; the major route of protein loss appeared to be the intestine. A full-thickness section of jejunum obtained at laparotomy demonstrated a severe, diffuse vasculitis involving the venules of the submucosa and muscularis externa with infiltration of polymorphonuclear leukocytes and macrophages, and deposits of C3. There was a similar focal damage of the walls of the small vessels in the lamina propria, and deposits of C3 and fibrinogen in a thickened basement membrane of the intestinal villi. This report documents that in systemic lupus erythematosus the intestine can be affected with a vasculitis similar to that seen in the skin and can cause thickening of the basement membrane of intestinal villi. These lesions may be responsible for protein-losing enteropathy.
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PMID:Systemic lupus erythematosus and intestinal venulitis. 701 90

A 12-year-old girl, who was later found to have systemic lupus erythematosus (SLE), had a protein-losing enteropathy. Histologic documentation of intestinal lymphangiectasia in the absence of congestive heart failure, retroperitoneal masses, or constrictive pericarditis marks this case as demonstrating a unique association of SLE with intestinal lymphangiectasia.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. 715 12

The case of a woman with SLE and protein-losing enteropathy secondary to intestinal lymphangiectasia is described. Corticosteroid therapy improved all clinical symptoms, laboratorial findings and intestinal histological alterations.
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PMID:Intestinal lymphangiectasia in systemic lupus erythematosus. 724 48


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