Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A previously well 36 year old man presented with cardiac tamponade as the initial manifestation of systemic lupus erythematosus. This diagnosis should, therefore, be considered not only in cases of pericarditis but also in those of tamponade.
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PMID:Systemic lupus erythematosus presenting with cardiac tamponade. 670 65

We evaluated the complement system in 20 patients presenting with a first episode of meningococcal meningitis, meningococcemia, or meningococcal pericarditis. Assays of total serum complement activity were performed prospectively in 12 patients and retrospectively in 8. Six of the twenty patients had a complement deficiency (CH50 greater than 2 S.D. below the normal mean). Three of these six had a deficiency of a terminal-pathway protein (C6 in two and C8 in one), and the other three had deficiencies of multiple complement proteins associated with underlying systemic lupus erythematosus or multiple myeloma. Patients with decreased amounts of complement were similar to normal patients in terms of sex, age, type of infection, and meningococcal serogroup, but 3 of the 6 patients with a complement deficiency were black, as compared with none of the 14 patients with normal function (P = 0.018). Complement deficiency is common in patients with a first episode of meningococcal disease and may be due to either a deficiency in a single terminal protein or a complement-depleting underlying illness.
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PMID:Prevalence of congenital or acquired complement deficiency in patients with sporadic meningococcal disease. 683 95

The clinical features of early cases of systemic lupus erythematosus (SLE) in 67 (55 female and 12 male) patients are reported in a prospective study and its prevalence rate is calculated. The disease accounted for 0.67% of all medical admissions and it was the third most frequent inflammatory rheumatic disease. By comparison with rheumatoid arthritis and extrapolation of the data, the prevalence of SLE was one case per 1867 of the population, one per 1127 of the total female population and for women aged between 10 and 49 years it was one per 616. Multisystem involvement was noted in all patients. Our results were presented and compared with other studies. Significant differences between our study and others were noted with respect to alopoecia, mouth ulcers, pericarditis and pleurisy. Subclinical involvement of the liver was noted in 26% and of the lungs in 19%. Hepatomegaly was noted twice as often in younger compared with older patients. SLE is a disease with an apparently increasing prevalence in Iraq. There is a need for a greater awareness on the part of practising physicians and more widespread availability of sensitive laboratory tests for diagnosis of the disease.
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PMID:Clinical features of early cases of systemic lupus erythematosus in Iraqui patients. 687 84

Two patients with systemic lupus erythematosus (SLE) had pericardial tamponade. The pericardial fluid from both patients contained "mixed" type cryoglobulins consisting of IgG, IgM, and C1q. There was a selective concentration of antinuclear antibodies in the pericardial fluid cryoglobulin of one patient. Pericardial fluid from the same patient contained immune complexes. Anti-DNA antibodies were found in the serum, pericardial fluid, and pericardial fluid cryoprotein. Immune complexes isolated from the pericardial fluid by polyethylene complexes isolated from the pericardial fluid by polyethylene glycol precipitation contained antinuclear antibodies including anti-DNA antibodies. Immune complexes may be important in the pathogenesis of pericarditis in SLE.
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PMID:Immune complexes in the pericardial fluid in systemic lupus erythematosus. 696 47

Pleural pericarditis, fever, and a positive reaction for antinuclear antibody developed in a 50-year-old white woman while she was receiving methyldopa (500 mg daily). After withdrawal of the drug, there was complete resolution of the clinical signs and symptoms, as well as normalization of the patient's antinuclear antibody titer. To our knowledge, this is the first reported case of a clinical lupus-like syndrome induced by therapy with methyldopa.
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PMID:Systemic lupus-like syndrome induced by methyldopa therapy. 697 39

Review of 3,084 autopsies from 1967 to 1977 at Grady Memorial Hospital Yielded 14 cases of myocardial abscess unassociated with infective endocarditis acceptable for our study. No case was diagnosed ante mortem. Gram-negative organisms, fungi, and Staphylococcus aureus were isolated. Underlying conditions included alcoholic hepatitis, acute myocardial infarction, systemic lupus erythematosus, and various malignancies. The physical examination, chest roentgenogram, and electrocardiogram were not helpful in establishing a diagnosis. complications included pericarditis and congestive heart failure. A high index of suspicion in a debilitated patient not responding to conventional antimicrobial therapy appears to be the only clue to the antemortem diagnosis. Cardiac scintigraphy is promising as a possible means of earlier detection.
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PMID:Myocardial abscesses unassociated with infective endocarditis. 701 88

A 12-year-old girl, who was later found to have systemic lupus erythematosus (SLE), had a protein-losing enteropathy. Histologic documentation of intestinal lymphangiectasia in the absence of congestive heart failure, retroperitoneal masses, or constrictive pericarditis marks this case as demonstrating a unique association of SLE with intestinal lymphangiectasia.
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PMID:Protein-losing enteropathy in systemic lupus erythematosus. 715 12

This report concerns a retrospective study of 14 patients with systemic lupus erythematosus (SLE) of onset after age 50, the clinical, evolutive, and therapeutic aspects having been evaluated. Eleven patients were female and three were male. Mean age of onset of symptoms was 60 years. Most frequently observed symptoms were arthralgias and/or arthritis, followed by pleurisy and/or pericarditis. A high incidence of liver involvement was noted. All the patients were treated with 6-methyl prednisolone. Four patients died, two as a consequence of chronic renal failure, and two from complications likely related to corticosteroid therapy. It is concluded that SLE of late onset has certain clinical and therapeutic features that distinguish it from that of earlier onset.
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PMID:[Systemic lupus erythematosus with late clinical onset (author's transl)]. 725 44

A retrospective study of 112 cases of lupus erythematosus, 103 acute disseminated lupus erythematosus (ADLE) and 9 chronic discoid lupus (CDL), was conducted to determine the incidence of disorders of conduction (DC), and to study their prognosis and discuss their pathogenicity. The mean age of the group was 38 +/- 16 years, and the mean follow-up period after discovery of the DC was 53 months. Cardiac lesions were present in 49.5 p. cent of the 103 patients with ADLE : pericarditis in 27 p. cent, murmur from lupus endocarditis or cardiomyopathy in 23 p. cent, heart failure in 4.8 p. cent, and hypertension in 17 p. cent. Disorders of conduction were present in 18 (17.5 p. cent) of the 112 patients studied. These included 5 partial right bundle-branch blocks (no complete right bundle-branch block), 2 complete and 3 partial left bundle-branch blocks, 5 complete, 2 first degree, and 1 second degree atrioventricular blocks (AVB). The atrioventricular blocks were usually located in the truncal or fascicular regions, but in 2 cases they were nodal in origin. The 5 complete AVB were associated with ADLE in two cases and CDL in the three other cases. The AVB in the ADLE cases appeared 9 to 20 years after the onset of the lupus, these two patients developing pericardiomyocarditis unaccompanied by disorders of conduction. The three complete AVB occurring during CDL were detected 9 to 18 months after the diagnosis. A fatal outcome was noted in 13 (12.5 p. cent) of the ADLE patients and one of the 9 cases of CDL. Ten-year survival curves showed no difference in prognosis for the groups with or without disorders of conduction, but mortality increased in patients with DC after 10 years. As disorders of conduction were more frequently observed in patients with lupus than in a control population, they can be attributed to either a lupus myocarditis or prolonged administration of synthetic antimalarial agents. Disorders of conduction, and particularly complete AVB are, in fact, observed in patients without pericardiomyocardial lesions, and when they exist usually develop a long time after the onset of the cardiac lesion. All patients had been treated with antimalarials, however, and the onset of the DC was associated with a chloroquine myopathy in some of them. Three of the five complete AVB were observed during the course of CDL in patients without cardiac lesions, this being a supplementary argument for implicating synthetic antimalarials.
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PMID:[Disorders of conduction in lupus erythematosus : frequency and incidence in a group of 112 patients (author's transl)]. 730 72

To alleviate recurrent pericardial effusion secondary to systemic lupus erythematosus, pericardio-peritoneal window was performed. Subsequently, end stage renal disease developed and the patient required peritoneal dialysis. Patency of the pericardio-peritoneal window was demonstrated by intraperitoneal injection of Tc-99m SC through a Tenckhoff catheter, which prompted special counsel to the patient in order to prevent infectious pericarditis potentially complicating peritoneal dialysis induced-peritonitis.
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PMID:Scintigraphic assessment of pericardio-peritoneal window patency. Relevance to peritoneal dialysis. 755 64


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