Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of retinal vasculitis in SLE-type diseases are reported. The first was central retinal vein occlusion occurring during clinical remission of SLE in a 55 year old black female. Prednisone maintenance therapy was unchanged and visual loss rapidly regressed with heparin therapy. The second case was a 33 year old black female in whom SLE was discovered following relapsing bilateral optic neuritis. A progressive visual improvement was obtained with high dose of prednisone (1 mg/kg/day). The third cas was a 17 year old white girl with retinal vasculitis. She had an unclassified connective tissue disease inaugurated by optic neuritis at the age of 10. High dose prednisone (1 mg/kg/day) was effective on the visual loss. Retinal vasculitis lesions in SLE and their therapy are reviewed.
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PMID:[Retinal vasculitis in lupic disease]. 400 39

At 20 year-old a patient developed a paraplegia which regressed within several months, suggestive of an acute myelitis. Subsequently, several episodes of spastic paraplegia, posterior tracts lesions and retrobulbar optic neuritis, a transient cerebellar syndrome, modifications in cerebrospinal fluid (pleiocytosis, hypergammaglobulin levels, elevated Delpech's ratio) suggested multiple sclerosis. When aged 62 years, the patient developed articular lesions, Raynaud's phenomenon, and buccal ulcers attributed to lupus. LE cells, native DNA anti-antibodies, anti-Sm auto antibodies on immunofluorescence were present. The possibility of a collagen disease, expressed initially and for a long period in an exclusively neurological disorder is discussed. It was considered, however, to be more likely two distinct affections. This association has been reported very rarely, even though two immunity-mediated inflammatory affections are involved.
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PMID:[Multiple sclerosis and lupus]. 609 17

In a 44 years old woman, a flare up of polyarthritis becoming positive for sero-reaction at the time of hospitalization, is referred to an earlier unknown SLE. The bilateral optic neuritis which began 15 years earlier, while she was pregnant, simultaneously with a bilateral carpal tunnel syndrome is retrospectively related to the SLE. Such an optic neuritis is rare, its clinical features are specified among the neuro-ophthalmological complications in SLE. Very often optic neuritis is associated with myelopathy. Hypercytosis with moderate elevation of albumin C.S.F., a high level of cyclic GMP, and a low concentration of IgG in C.S.F., are found in central neurological complications in SLE. Other biological alterations are described but both their signification and their interest, as well for diagnostic as for therapeutic supervision, are unknown. Neuropathological findings show either vasculitis or demyelinizing lesions. This case shows the therapeutic problems of such medical situations.
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PMID:[The neuro-ophthalmological complications in SLE (author's transl)]. 626 4

Unilateral optic neuritis and Jaccoud's Syndrome in a 34-year-old woman suffering from systemic lupus erythematosus is presented. We discuss the probable pathophysiological mechanisms of these two uncommon conditions. The most acceptable incriminating factor for optic neuritis is vasculitis.
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PMID:Optic neuritis and Jaccoud's syndrome in a patient with systemic lupus erythematosus. 665 1

Color thresholds in a series of patients with local or systemic diseases were determined by a chromagraph method and subjected to computer analysis. When compared with normal persons, those with optic nerve disease (multiple sclerosis, optic neuritis, and optic atrophy) showed an overall weakness for all colors (enlarged neutral areas), with an additional specific defect in the orange-cyan (greenish blue) axis. Those with the two retinal diseases studied (macular degeneration and retinitis pigmentosa) also showed threshold elevation for all colors, but with a special defect in the yellow-blue axis. The general elevation was greater for patients with retinitis pigmentosa than for those with macular degeneration, regardless of the visual acuity. In patients undergoing treatment for systemic lupus erythematosus and rheumatoid arthritis, there was a mild elevation of the color threshold, especially for yellow.
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PMID:Clinical studies of color vision with Gunkel's chromagraph. 688 52

Four patients with systemic lupus erythematosus (SLE) and optic neuritis are described. Optic neuritis is uncommon in SLE but may be the presenting feature of the disease. A review of 8 similar cases in the literature indicates that myelopathy is frequently associated, prompting the diagnosis of multiple sclerosis. Visual loss may be permanent despite therapeutic intervention, but rapid improvement occurs in some patients who receive early treatment with corticosteroids.
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PMID:Optic neuritis in systemic lupus erythematosus. 716 91

The appearance of systemic lupus erythematosus (SLE) after thymectomy (or thymomectomy) is presented in four patients together with a comparative review of additional reports found in a Medline search for the years 1966-94 in the English and French literature. Fourteen women and two men of average age of 39 years (range 11-66 years) at presentation, developed SLE after thymectomy (11 patients) or thymomectomy (five patients). Half developed SLE within 3 years after surgery (range 3 months to 18 years). The most common SLE manifestation was polyarthritis occurring in 15 of 16 patients either at presentation or during the first year. Other frequent manifestations included skin rashes, fever, cytopenias and pleuritis. Two rare manifestations of SLE, optic neuritis and transverse myelitis, were reported in two patients. Thymic hormone activity was measured in one patient and was undetectable compared with normal controls. HLA studies in eight patients showed the combination of A1, B8 in four. In conclusion, the appearance of SLE after thymectomy or thymomectomy appears to be more than a coincidence. It may provide insights into the pathogenesis of SLE.
Lupus 1995 Feb
PMID:Appearance of systemic lupus erythematosus after thymectomy: four case reports and review of the literature. 776 37

The authors describe an 11-year-old girl with systemic lupus erythematosus (SLE) who developed simultaneous bilateral acute optic neuritis. Severe initial visual loss followed by permanent visual deficit occurred in both eyes despite therapeutic intervention. Recurrence of optic neuritis in one eye caused the vision to deteriorate further. The most probable pathogenesis is occlusive vasculitis involving the small arterioles of the optic nerves.
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PMID:Bilateral simultaneous optic neuritis in childhood systemic lupus erythematosus. A case report. 795 33

Two patients had frequent attacks of acute myelitis and optic neuritis. One patient lacked any other organ involvement whereas the other developed systemic manifestations of systemic lupus erythematosus 14 years after the onset. Both patients developed antinuclear and antidouble strand DNA antibodies after the onset of neurological involvement. These patients, whose neurological manifestations were indistinguishable from multiple sclerosis, were thus considered to have systemic lupus erythematosus related collagen disease.
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PMID:Recurrent opticomyelitis associated with anti-DNA antibody. 808 84

Although the association between transverse myelitis (TM) and systemic lupus erythematosus (SLE) has been reported previously, it remains a rare clinical condition. Our experience treating three women with lupus TM within a few months is presented. In each patient, spinal cord dysfunction was accompanied by laboratory or clinical evidence of SLE. Further neurologic manifestations, such as optic neuritis, developed in all patients, suggesting other diagnoses, including multiple sclerosis (MS), Devic's syndrome, and lupoid sclerosis. The outcomes for these three women were severe disability, death, and moderate disability, respectively. The severity of outcome did not seem to correlate with the timing or intensity of treatment. Physiatrists should be aware of the potential for neurologic progression in lupus TM, because patients with this condition invariably require rehabilitation.
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PMID:Three women with lupus transverse myelitis: case reports and differential diagnosis. 955 15


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