Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case of a 39 years old woman with acute transverse myelitis manifested as a syndrome of the anterior spinal artery is presented. Etiologic investigation diagnosed a primary antiphospholipid syndrome because of the finding of significantly high titers of anticardiolipin antibodies discarding the presence of systemic lupus erythematosus for the lack of sufficient diagnostic criteria. The association between both clinical pictures is infrequent.
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PMID:[Acute transverse myelitis and primary antiphospholipid syndrome]. 143 4

Two flares of acute myelitis were observed in a 31-year-old woman with previously known mild SLE. The two myelitic episodes both occurred within 1 week after intense sun exposure, and for this reason photobiological induction of the manifestation is considered likely. The diagnostic utility of MRI in the acute situation and the possible influence of sex-steroids on SLE manifestations are also illustrated by this case.
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PMID:Two UV-induced episodes of myelitis in a patient with systemic lupus erythematosus. 145 33

Transverse myelitis is a rare but serious complication of systemic lupus erythematosus (SLE). Standard treatment with medium to high doses of oral prednisone has been inadequate to control neurologic sequelae, and patients remain confined to a wheel chair or even die. We employed aggressive treatment in 7 patients with transverse myelitis complicating SLE with pulse methylprednisolone for acute episodes followed by pulse cyclophosphamide for a mean of 6 months; most of our patients are currently able to walk and have partial or total sphincter control.
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PMID:Transverse myelitis in systemic lupus erythematosus--the effect of IV pulse methylprednisolone and cyclophosphamide. 157 49

Transverse myelitis is one of the most serious neurological complications occurring in the course of systemic lupus erythematosus. We describe two lupus patients, with transverse myelitis, one of whom had associated optic neuritis. In both, magnetic resonance imaging of the spinal cord showed an abnormal signal. In one case a good response to steroid and immunosuppressive therapy was observed; the other case failed to improve despite the therapy applied.
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PMID:Transverse myelitis in systemic lupus erythematosus: two cases with magnetic resonance imaging. 164 55

This study presents the case of a 32 year-old patient carrying a belatedly diagnosed systemic lupus erythematosus (SLE), who suddenly developed transverse myelitis. This complication had been preceded a few hours earlier by a sole neurological disorder consisting in a universal nystagmus. This neurological condition was accompanied by a renal syndrome revealed by a nephritic sediment with scarce functional repercussions. The patient was treated with a combination of high doses of methylprednisone and cyclophosphamide. The central neurological and renal disorder remitted, but it was impossible to reverse the patient's paraplegia, which became permanent. This paper includes a review of the 46 cases of transverse myelitis and SLE published so far with regard to diagnosis, treatment and results, a comparison with the case under study, and the conclusions drawn.
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PMID:[Transverse myelitis and systemic lupus erythematosus. A case report]. 182 26

We describe a patient with acute transverse myelitis as the first symptom of systemic lupus erythematosus who was successfully treated with cyclophosphamide and prednisone. The literature on transverse myelitis is reviewed and its clinical presentation, diagnosis, therapy and prognosis are discussed. A new therapeutic approach involving cyclophosphamide and prednisone is proposed.
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PMID:[Acute transverse myelitis in systemic lupus erythematosus: successful therapy with cyclophosphamide and prednisone]. 199 4

We describe a pair of monozygotic twins who are concordant for myasthenia gravis but discordant for systemic lupus erythematosus (SLE). SLE developed in twin 1 18 years post-thymectomy and has been characterized by recurrent transverse myelitis and optic neuritis. Twin 2 remains well post-thymectomy, except for a skin rash and persistent leukopenia. Both twins have developed autoimmune thyroid disease. We review genetic and environmental factors of importance in the pathogenesis of SLE and discuss the possible role of thymectomy in the etiology of the disease.
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PMID:A pair of monozygotic twins who are concordant for myasthenia gravis but became discordant for systemic lupus erythematosus post-thymectomy. 205 38

The authors provide disease histories of 4 patients afflicted with genuine systemic lupus erythematosus (SLE). There were 2 men and 2 women who developed acute transverse myelitis (ATM) at an age of 24 to 31 years. Before ATM developed, SLE standing was from 3 to 10 years. Based on the authors' and reported data, the problems of the pathogenesis, clinical picture, diagnosis and prognosis in that grave complication of SLE are discussed. As for the mechanisms of ATM development, the role of antiphospholipid antibodies is reviewed. The data on familial aggravation of the patients are presented in terms of the development of the antiphospholipid syndrome in their relatives. Emphasis is laid on the necessity of early intensive care with glucocorticoid hormones and cyclophosphamide of patients with associated SLE and ATM in order to improve their prognosis.
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PMID:[Acute transverse myelitis in patients with systemic lupus erythematosus]. 206 59

We describe a patient with systemic lupus erythematosus (SLE) who presented with acute transverse myelitis. Magnetic resonance imaging (MRI) of the cervical spine demonstrated increased signal intensity and diffuse edema in the cervical cord. The patient had low titer of IgG antiphospholipid antibodies and hypocomplementemia. Cerebrospinal fluid analysis showed pleocytosis, increased protein and decreased glucose. Clinical improvement of the neurologic impairment was noted after high dose corticosteroids and intravenous bolus cyclophosphamide. A repeat MRI 12 days after the treatment was normal. MRI of the spine can be useful in the diagnosis and followup of patients with SLE presenting with an acute myelopathic syndrome. Early aggressive treatment may contribute to complete recovery of these patients.
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PMID:Acute transverse myelitis in systemic lupus erythematosus: magnetic resonance imaging and review of the literature. 217 53

All 4 patients with transverse myelitis (TM) included in a prospective study of 500 patients with systemic lupus erythematosus (SLE) tested for anticardiolipin (aCL) antibodies were found to be positive. To determine if the apparently strong association between transverse myelitis and antiphospholipid antibodies (aPLA) in patients with SLE continued to hold, we chose 12 patients with SLE with transverse myelitis from 2 institutions. Eleven of the 12 patients with SLE were tested for aCL and all but one was positive. Most of them (n = 8) had both IgG and IgM isotype aCL. The one who was negative had had a positive VDRL and prolonged APTT 15 months earlier, coinciding with the episode of transverse myelitis. One patient died before she was tested for aCL but she also had a false positive VDRL. Thus, all 12 patients with SLE with transverse myelitis had evidence of aPLA. We conclude that there is strong association between transverse myelitis in SLE and the presence of aPLA.
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PMID:Transverse myelitis: a manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies. 209 69


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