Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is increasing evidence that, as in systemic lupus erythematosus (SLE), deposition of immune complexes plays a role in the pathogenesis of dermatitis herpetiformis (DH). Dermatitis herpetiformis and SLE were diagnosed in a 15-year-old girl with Marfan's syndrome who died of cardiac tamponade secondary to cystic medial necrosis of the ascending aorta. The concurrence of these diseases suggests that predisposition to immune-mediated disorders may be associated with the expression of multiple clinical entities.
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PMID:Systemic lupus erythematosus and dermatitis herpetiformis: concurrence with Marfan's syndrome. 76 Jun 61

Procainamide, a frequently sued antiarrhythmic agent, may produce a syndrome clinically indistinguishable from idiopathic lupus erythematosis. Pericarditis with or without effusion is occasionally a prominent manifestation of the disease, but cardiac tamponade is exceptional. The patient described had a clinically evident and laboratory confirmed drug-induced syndrome complicated by an unusually severe pericarditis with effusion and tamponade necessitating pericardiocentesis. Treatment with prednisone produced impressive amelioration of the pericarditis with no recurrence of the lupus erythematosis syndrome during a prolonged period of observation following cessation of corticosteroid therapy. Prompt initation of steroid treatment in drug-induced lupus erythematosus complicated by massive pericardial effusion is strongly suggested by this experience.
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PMID:Pericardial tamponade. A presenting manifestation of procainamide-induced lupus erythematosus. 112 94

Emergency pericardiocentesis, guided by a two-dimensional echocardiography, was performed on twenty patients with symptomatic pericardial effusion of various types and causes. There were fourteen men and six women. The underlying causes were: primary lung cancer (6 cases), metastatic cardiac tumors (3 cases), tuberculosis (4 cases), complicated interventional procedures with cardiac chamber or vessel perforations (2 cases), dissecting aortic aneurysm (1 case), systemic lupus erythematous (1 case), idiopathic pericarditis (1 case), bacterial pericarditis (1 case), and myxedema heart disease (1 case). Seventeen cases were performed through the left xipho-sternal approach and 3 cases through the apical approach. None of the patients died as a result of these procedures. A two-dimensional echocardiogram is useful in diagnosing cardiac tamponade as well as in guiding pericardiocentesis, and obtaines highly positive results (20/20). The positive rate of pericardial fluid cytology for malignant cells was 89% (8/9), however, pericardial fluid cultures or direct smear for tuberculosis were negative (0/4). In cancer patients, the mean survival time following pericardiocentesis was 4.2 months (range, 1-7.8 months). We concluded that neoplastic involvement of the pericardium is the most frequent cause of symptomatic pericardial effusion. Pericardiocentesis assisted by a two-dimensional echocardiogram is safe and easy. In addition, pericarditis caused by TB is still significant and must be considered in every case in our nation.
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PMID:Pericardiocentesis: a 20 patients study. 133 Feb 47

Cardiac tamponade is rare as an initial manifestation of systemic lupus erythematosus (SLE), and even more so in paediatric patients. This paper reports an 8 year old girl with SLE with several unusual features: unusual age of presentation, unusual initial organ manifestation and recurrent cardiac tamponade as a complication.
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PMID:Cardiac tamponade as an initial manifestation of systemic lupus erythematosus in early childhood. 155 Apr 18

We report the case of a 21 year-old woman who developed systemic lupus erythematosus and fatal cardiac tamponade. Necropsy examination revealed cardiac tamponade as well as other findings of SLE and an unsuspected vasculitis similar to polyarteritis nodosa.
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PMID:[Fatal cardiac tamponade in systemic lupus erythematosus associated with vasculitis similar to polyarteritis nodosa]. 209 27

A prospective analysis of 30 Egyptian children with systemic lupus erythematosus (SLE) was conducted throughout a 3 year period. The average followup period was 13 months. The age of onset ranged from 8 to 14 years. Most cases presented with more than one of the classical features of the disease. However, 23.3% presented primarily with major organ involvement. One case presenting with cardiac tamponade is reported in our series. The clinical and laboratory manifestations of the disease are presented, though more complete studies are required to confirm any possible differences in these disease manifestations compared with those found in other populations. Contrary to the frequently held view, our results suggest that childhood onset SLE is not rare in Africa or at least some parts of the continent.
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PMID:Juvenile systemic lupus erythematosus among Egyptian children. 229 Jan 56

Although pericarditis is the most common cardiac complication of systemic lupus erythematosus (SLE), cardiac tamponade is distinctly unusual. We report one patient whose initial predominant manifestation of SLE was cardiac tamponade and review the cases of 12 patients with similar presentations.
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PMID:Cardiac tamponade as an initial manifestation of systemic lupus erythematosus. 268 97

A very-low-birth-weight infant died from pericardial effusion and cardiac tamponade confirmed by the post-mortem findings. The mother suffered from lupus-like syndrome consequent to hydralazine treatment for pregnancy-induced hypertension. The possible relationship between mother-infant pathology and hydralazine administration is discussed.
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PMID:Lupus-like syndrome in a mother and newborn following administration of hydralazine; a case report. 270 4

Although in SLE pericarditis is common, cardiac tamponade is rare and its usual treatment has been effusion drainage. A 19-year-old girl presenting with cardiac tamponade was diagnosed with SLE. Treatment with indomethacin rapidly reduced the hemodynamic compromise, avoiding the need for pericardiocentesis.
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PMID:Resolution of cardiac tamponade in systemic lupus erythematosus with indomethacin. 280 50

Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis. After cessation of the sulfasalazine and completion of a six-week course of corticosteroids, these problems resolved over a period of four to six months. It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms. Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.
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PMID:Sulfasalazine-induced lupus erythematosus. 289 66


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