Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of adsorbent plasmapheresis using dextran sulfate columns on anti-DNA and/or anticardiolipin antibodies (aCL) in 6 patients with systemic lupus erythematosus (SLE) was studied by multicenter clinical trials. The titers of anti-DNA (RI assay), IgG anti-dsDNA (ELISA), IgG and/or IgM anti-ssDNA, (ELISA), and IgG aCL (ELISA) significantly decreased or normalized after 4 treatments of plasmapheresis during a 2 to 4 week period. A patient with SLE with recurrent abortion and aCL who was successfully treated by adsorbent plasmapheresis is reported. We expect that adsorbent plasmapheresis will be an influential treatment for patients with not only SLE but aCL syndrome.
 ...
PMID:Selective removal of anti-DNA and anticardiolipin antibodies by adsorbent plasmapheresis using dextran sulfate columns in patients with systemic lupus erythematosus. 206 47

Recurrent thrombosis, abortion and thrombocytopenia are the most frequent manifestation of antiphospholipid syndrome, which usually presents antibodies against some anionic phospholipids. A few years ago, this syndrome was considered as a manifestation of systemic lupus erythematosus; nowadays it is classified as an isolated systemic lupus erythematosus; nowadays it is classified as an isolated autoimmune disease. Hypotheses have been proposed to explain the origin of antiphospholipid antibodies, including infectious and autoimmune diseases with high titles of anticardiolipin antibodies. Genetic factors have also been involved. Laboratory tests of choice for the detection of anticardiolipin antibodies are RIA and ELISA tests; there are some structural differences among them depending on the underlying disease. Hypercoagulability and recurrent thrombosis are the main features of this entity; ischemic heart disease is in this context of outmost importance. Despite the lack of any clinically demonstrated association between antiphospholipid syndrome and ischemic heart disease, there are many "in vitro" studies that support this possibility.
 ...
PMID:[Antiphospholipid syndrome and cardiovascular disease]. 210 94

A 33 year old woman with severe thrombocytopenic purpura complicated by typical lupus anticoagulant developed repeated spontaneous abortion, deep venous thrombosis, and cerebral thrombosis. The platelet count fluctuated from 4,000 to 400,000/mm3 during the 13 year clinical course. The physical and laboratory findings at the time of severe thrombocytopenic purpura were compatible with the criteria of idiopathic thrombocytopenic purpura except for positive lupus anticoagulant. Both immunosuppressive therapy with prednisolone and antithrombotic therapy with warfarin and aspirin were necessary for the control of bleeding and venous and arterial thrombosis.
 ...
PMID:Thrombocytopenic purpura in a patient with lupus anticoagulant: requirement of both immunosuppressive and antithrombotic therapies. 206 61

We have studied, prospectively, the incidence of several antiphospholipid antibodies (lupus anticoagulant, anticardiolipin, anti-phosphatidylserine, anti-phosphatidic acid, anti-phosphatidylinositol and anti-thromboplastin antibodies) in 65 consecutive patients with two or more (range 2-8, mean 3.1) abortions. Lupus anticoagulant activity was detected in seven (10.7%) patients and all of them exhibited other antiphospholipid antibodies. Of the previous pregnancies in these seven women, 88% had ended in spontaneous abortion. Four of them achieved pregnancy after low-dose aspirin therapy was started, and carried successfully to term. It is concluded that antiphospholipid antibodies, namely lupus anticoagulant, should be routinely screened in the recurrent spontaneous aborter.
 ...
PMID:Antiphospholipid antibodies in unselected patients with repeated abortion. 210 83

Twenty-one patients with anti-phospholipid antibodies (APLA), who were selected from 104 patients with antinuclear antibody or anti-DNA antibody, were studied to define clinical characteristics of APLA. Of the 21 patients, the incidences of IgG anti-cardiolipin antibody (ACA), IgM ACA, lupus anticoagulant (LAC) and BFP-STS were 20, 7, 11 and 12, respectively, and they were highly related with each other. The number of items of the 1982 ARA revised criteria for the classification of SLE was significantly low (mean value = 3.3), and also the level of serum C 4 was significantly high (mean value = 88% of normal) compared with those in patients without APLA. The incidence of thrombocytopenia and hemolysis was significantly high when compared with those in patients without APLA, and they were closely related to the presence of LAC. The incidence of thrombosis was markedly high (48%), 10 of 21 patients, especially those of cerebral infarction and deep vein thrombosis. Cerebral infarction was significantly associated with LAC. The obstetric complication was 4 of 13 patients (31%) in the incidence, which was significantly high compared with that in patients without APLA. Of them, natural abortion was closely associated with LAC. Based on these observations, it seems that autoimmunological disease activity in patients with APLA may be slight to mild, and strongly suggested that APLA may play an important role particularly in the pathogenesis of acquired thrombotic tendency.
 ...
PMID:[Clinical characteristics of anti-phospholipid antibodies]. 211 74

More than 95 per cent of the pregnancies with circulating lupus anticoagulant (LA) without therapy lead to abortion or intrauterine death. We report on the course of a pregnancy in a patient, who developed deep venous thrombosis and circulating LA. One of the rare cases of successful pregnancy management without the common prednisolone-aspirin therapy, but with heparin-monotherapy associated with intensive medical and obstetrical surveillance under clinical conditions is reported. In spite of intermittent corticosteroid and immunoglobulin application, a healthy child was born, although normalisation of the aPTT and platelet count was not achieved. It seems, that an alternative concept of therapy may have been established.
 ...
PMID:[The course of pregnancy in lupus anticoagulant syndrome]. 212 Jan 7

Patients with systemic lupus erythematosus often develop thrombosis, recurrent abortion, thrombocytopenia and neurological disease, in association with serum antibodies against phospholipids, termed the secondary antiphospholipid syndrome. In our search for an animal model for the human antiphospholipid syndrome, we examined the MRL-1pr/pr mouse, which develops a lupus-like illness. These mice were found to have significantly elevated levels of serum antiphospholipid antibodies (aPL) and thrombocytopenia compared to normal mice. By immunodiffusion, these antibodies are similar to human aPL. We observed histologic evidence of central nervous system thromboses as well as perivascular infiltrates of the choroid plexus. The high titers of serum aPL, thrombocytopenia, and thrombosis establish this strain as an animal model for the secondary antiphospholipid syndrome.
 ...
PMID:Autoimmune MRL-1 pr/1pr mice are an animal model for the secondary antiphospholipid syndrome. 212 Apr 36

The presence of antibodies to cardiolipin and the lupus anticoagulant were investigated in 189 couples with recurrent abortion. Abnormal coagulation results as measured by an elevation of the APTT or KCT were found in 6% and 7% of patients, respectively; however, the lupus anticoagulant was detected in only 3% of patients. Anticardiolipin antibody levels higher than normal were found in 15% of patients. There was no significant difference between parameters in primary as compared to secondary recurrent aborters or subfertile compared to fertile recurrent aborters. The success of the next pregnancy could not be predicted by any of the laboratory tests.
 ...
PMID:The lupus anticoagulant, anticardiolipin antibodies, and recurrent miscarriage. 212 Nov 57

Antiphospholipidsyndrome is a well-defined entity characterized by spontaneous abortion, thrombocytopenia and recurrent arterial and venous thromboses. The diagnosis is biochemically verified by the presence of antibodies binding to negatively charged phospholipids. A patient with recurrent thromboembolic complications over the years eventually developed a rapidly progressing dyspnoe. Two-dimensional echocardiography showed a large right atrial mass which at operation proved to be a thrombus. Coombs test was positive as were lupus anticoagulans and antibodies against cardiolipin, in addition to thrombocytopenia and prolonged bleeding time. The author reviews the literature and discusses problems regarding diagnostical criteria for antiphospholipidsyndrome, pathogenesis of the "procoagulopathy" and thrombembolic complications associated with the syndrome. Special consideration is given to non-invasive diagnostic methods for distinguishing between atrial myxom and floating thrombus.
 ...
PMID:[Antiphospholipid syndrome with massive right atrial thrombus. Differential diagnosis of myxoma]. 213 29

Even in 1990 there are still conflicting views concerning oral contraception (OCs) and risks associated with pregnancy in women with systemic lupus erythematosus. With regard to OCs, all authors agree that estrogen-progestin combinations are harmful, but the best alternative hormonal contraception has yet to be found. Progestin-based micropills seem to be harmless; cyproterone acetate appears to have no side effects and its usefulness in preventing recurrences is being evaluated. With regard to pregnancy, it would be wise not to contemplate having a child until 6 months have passes since onset of remission. Blood pressure, platelet count, and serum creatinine and uric acid levels must be closely monitored. 2 types of antibodies may be present in the mother and may be responsible for fetal complications. These are antibodies to phospholipids (antiprothrombinase, anticardiolipin, antibodies responsible for dissociated treponema serology), which expose patients to spontaneous abortion or intrauterine death, and the antibody to SS-A (or anti-Ro), which exposes patients to fetal cardiomyopathy and congenital atrioventricular block. (author's modified)
 ...
PMID:[Contraception and pregnancy in systemic lupus erythematosus]. 223 88


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>