Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024141 (
systemic lupus erythematosus
)
44,322
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Intestinal goblet cells of patients with ulcerative colitis and Crohn's disease highly express a binding protein of the Fc portion of IgG (
FcgammaBP
), which is entirely different from the Fcgamma receptors I,II, and III on neutrophils and macrophages. In this study, we proved the qualitative existence of
FcgammaBP
antigen in the sera of patients with rheumatoid arthritis and
systemic lupus erythematosus
, and, further, established a highly sensitive and quantitatively reproducible assay for
FcgammaBP
antigen in order to prevent the cross-reactivity of
FcgammaBP
with von Willebrand factor which has about 30% homology. This assay revealed a higher level of
FcgammaBP
antigen in the blood stream of patients with autoimmune diseases, especially progressive systemic sclerosis. This would suggest that abnormal production of autoantibodies reflects increased generation of
FcgammaBP
in goblet cells and its secretion into the circulation by an unknown mechanism.
...
PMID:Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases. 1160 Feb 3
