Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Per-rectal portal scintigraphy with Tc-99m pertechnetate is a method to evaluate portosystemic shunting (shunt index) in inferior mesenteric vein. In this study the shunt index was estimated in patients with chronic liver disease in relation to the severity of liver injury, portal hypertension and incidence of oesophageal varices. Shunt index was elevated in patients with non-cirrhotic liver disease as compared with healthy normals (34 +/- 6% vs 8 +/- 2%; p < 0.0005). Moreover, patients with cirrhosis had the shunt index of 65 +/- 4% which was higher than in other groups. There was no correlation of the shunt index to the Child-Pugh classification, hepatic venous pressure gradient and varices size in the cirrhotic patients. Conversely, the shunt index differentiated variceal bleeders from non-bleeders (80 +/- 4% vx 59 +/- 6%; p < 0.005). These data show that peripheral collateral circulation develop in response to mild elevation of portal pressure, but its hemodynamic efficacy to alleviate portal hypertension seems to be unremarkable. High shunt index might reflect elevated risk of bleeding from varices.
Pol Arch Med Wewn 1994 Jul
PMID:[Per-rectal scintigraphy of the portal system with pertechnetate TC-99M: clinically useful examination of patients with chronic liver disease.Part I]. 797 85

In 28 patients with liver cirrhosis as compared with the control group decreased concentrations of alpha 2-antiplasmin, antithrombin III and activator plasminogen inhibitor were observed. Decrease of these inhibitors was lower in advanced stages of cirrhosis accompanied by hypoalbuminemia and hyperbilirubinemia.
Acta Haematol Pol 1994
PMID:[Plasma serine protease inhibitors in patients with liver cirrhosis]. 806 85

Differential value of ACE activity and acid alpha 1-glycoprotein was evaluated in the selected liver and biliary tract diseases. The study involved 75 patients divided into 4 subgroups, according to the character of their disease: patients with the acute viral hepatitis, chronic viral hepatitis, liver cirrhosis, and cholelithiasis. It was found that ACE activity was significantly increased in all pathologies involving liver parenchyma, and normal in patients with extrahepatic cholestasis. It was also shown that simultaneous assays of ACE and acid < alpha 1-glycoprotein may serve as a sensitive test differentiating jaundice in parenchymal hepatic diseases from that in the course of extrahepatic pathology.
Pol Tyg Lek
PMID:[Activity of angiotensin converting enzyme I and levels of acid alpha glycoprotein in selected liver and biliary tract diseases]. 823 40

A case of a 54-year patient with decompensated liver cirrhosis is presented. As a major symptom rapidly increasing hydrothorax on the right side without marked ascites was observed. Diagnosing and simultaneously establishing etiology of hydrothorax on the base of clinical and laboratory findings was a difficult process. Imaging tests did not show any signs of splenomegaly.
Pol Tyg Lek
PMID:[Hydrothorax as a major symptom of decompensated liver cirrhosis]. 823 46

In 462 left testes of males, died in the age of 17-91 years (x = 51,9 +/- 16,8 years) the occurrence frequency and the degree of teratospermatogenesis activity was assessed. In the whole material, the phenomenon occurred in 84% of cases. In 47,83% of cases the grade of intensity was low (+), in 22% high ( ), in 14% moderate (++). Alcoholic intoxication occurred to have the heaviest impact on teratospermatogenesis frequency (92,5%); in liver cirrhosis the occurrence frequency was significantly more rare (76%). The age of cadavers and the weight of the gonad did not correlate with teratospermatogenesis occurrence frequency. Postmortem autolysis was not connected with the phenomenon occurrence also. It correlated positively albeit with type II and III seminiferous tubules, i.e. with tubules, where spermatogenesis was stopped on the stage of spermatids and spermatocytes, and negatively with hyalinized tubules, and also with the V% value of tubular membranes.
Patol Pol 1993
PMID:Studies on teratospermatogenesis occurrence in man. 836 13

Genetically determined impairment of copper excretion from the liver into the bile in Wilson's disease (WD) cause that "free copper" is accumulated in toxic amounts not only in the liver, but also in other organs. In WD liver biopsy often could not be made because of serious disturbances in hemostasis. The aim of the study was: a) to demonstrate our 9 patients with various form of WD. b) to examine some blood clotting factors and compare the results with these obtained in other liver diseases. The diagnosis of Wilson's disease was made on the basis of disturbed copper metabolism. Among our 9 patients (8 women and 1 man, between 17-33 years old) we diagnosed: 3 patients with fulminant Wilson's disease with all day deep jaundice, hemolytic anemia, haemorrhagic diathesis and liver failure, died, 2 patients with active chronic hepatitis, hemolytic anemia and haemorrhagic diathesis, 2 patients with liver cirrhosis, haemorrhagic diathesis, Kayser-Fleisher ring, neuropsychiatric syndrome, 2 asymptomatic patients without haemorrhagic diathesis. The prothrombin index and the factors of prothrombin stem (II, V, VII, X) were lower than in other kinds of cirrhosis. After treatment with d-penicillamine the clothing factors returned near to the norm, similar as the biochemical and immunological results.
Pol Tyg Lek 1995 Sep
PMID:[Wilson's disease in personal material--disturbances in hemostasis]. 865 42

Plasma prekallikrein (PPK) is a single-chain glycoprotein synthesized in the liver. The aim of our study was to evaluate a plasma prekallikrein as the marker reflecting liver protein synthesis in patients with chronic liver diseases. PPK levels have been measured by own modification of amidolytic micro-assay in 43 patients with chronic liver diseases and 37 healthy volunteers as control group. As compared to control group, PPK level was significantly decreased in patients with chronic active hepatitis and with decompensated liver cirrhosis and significantly increased in patients with liver cirrhosis complicated by hepatocellular carcinoma. There was no difference in plasma prekallikrein between patients with compensated liver cirrhosis and controls. The results suggest that PPK might be a useful index for the assessment of residual functional liver mass in patients with chronic liver diseases.
Pol Arch Med Wewn 1995 Nov
PMID:[Plasma prekallikrein in chronic liver diseases]. 883 36

A case of 25 years lasting semi-invasive (necrotic) aspergillosis is presented. Aspergilloma in the probably post-tuberculous cavity was the first sign of the disease. Then, in the course of disease, two broncho-pleural fistulas, bronchiectases and cirrhosis of the lung were observed. Effective antifungal treatment with itraconazole was followed by pneumonectomy of the affected lung.
Pneumonol Alergol Pol 1996
PMID:[Chronic semi-invasive aspergillosis with broncho-pleural fistula treated with itraconazole and surgically]. 898 50

Influence of liver pathology on changes in concentrations of individual thyroid hormones, in spite of extensive investigations, remains obscure and the presented opinions are conditionary. The aim of the work was to show whether impairment of liver function (cirrhosis, chronic active hepatitis CAH) affects basic concentrations of TT3, TT4, fT3, fT4 and TSH. The investigations were carried out in 30 males (mean age 51.8 years) with cirrhosis of the liver and in 30 males (mean age 38.9 years) with CAH. The diagnosis was established on the basis of the clinical picture, results of biochemical and serological blood tests, as well as on histopathological examination of liver samples. The control group consisted of 20 male healthy volunteers. Fasting blood samples were collected between 7 and 8 a.m. Concentrations of TT3, TT4, fT3, fT4 and TSH were estimated with the RIA method. A significant decline of TT3, TT4, fT3, fT4 concentration and TT3/TT4 index in males with liver cirrhosis were observed.
Pol Arch Med Wewn 1996 Oct
PMID:[Levels of pituitary-thyroid axis hormones in men during the course of chronic active hepatitis and liver cirrhosis]. 908 43

The 19,094 autopsy examinations carried out between 1976-1990 revealed 698 (3.65%) case of cirrhosis, of which 64.6% were men. During the last 5 years the percentage of coexistance of hepatoma (hepatocellular carcinoma) with cirrhosis was higher 5-year periods (5.8%; 5.4%). Moreover, the same changing interrelation was observed for other malignancies and cirrhosis-higher (15%) in the last period than in the proceeding years (11.1%; 11.3%). The severity of atherosclerotic changes and coexistance of peptic ulcers, gall bladder disease and productive pulmonary tuberculosis in cirrhotic patients were also assessed. Finally the direct causes of these patients' death were discussed.
Pol Merkur Lekarski 1996 Sep
PMID:[Coexistence of some diseases and analysis of death causes based on autopsy examinations carried out in liver cirrhosis patients based on autopsy observations in 1976-1990]. 913 85


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