Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

INTRODUCTION: Huanta is an interandean valley at 2,400 meters above sea level in the peruvian highlands. It is hyperendemic for HBV, and deaths related to HBV such a fulminant hepatitis, cirrhosis and hepatic carcinoma make up 8% of the total mortality. A pilot program of inmunization against HBV integrated with the Expanded Immunization Program (EPI) was established in 1994, so as to limit the incidence if HBV-HDV, and as a strategy to improve EPI coverages.MATERIALS AND METHODS: A total of 1,412 children under 1 year old and 5,175 children from 1 to 4 years old were scheduled for vaccination. Three doses of the recombinant DNA vaccine agains HBV were used for each child. The schedule was adapted to the EPI vaccination calendar. In children under a year the schedule was: newborns: BCG, Polio, HBVI; 2 months: Poliol DPTI, HBV2; 3 months: Polio 2, DPT2; 4 months: polio 3, DPT3, HBV3; 9 months: Measles. In the group of children from 1 to 4 years old, the schedule was: HBVI at child recruitment; HBV2: after 2 months of the first one, HBV3: after 6 month of the first one.RESULTS: One year after starting, 3 dose immunizations have been made in 1,386 (98.1%) children under one year old and 4,353 (84.1%) in children from 1 to 4 years old. No important side effects related to the HB vaccine have been recorded; one case of HAV and two of HBV occurred in children who were beginning their immunization schedule. The objective of improving vaccination coverage by the EPI was achieved; the coverage in children under one year old for DPT were 76% (1991), 64.5% (1992), 55.2% (1993), and as a result of the strategy the coverage was improved to 98.1%. The program efficacy is demonstrated by the significative reduction of the infection rates of children 3-4 years old in 1994 (24.4-30.4%) compared with the children infection rates of the same age in 1997 (2.3-5.1 %).CONCLUSION: Including the HBV vaccine within the EPI program in a hyperendemic area for HBV-HDV has improved the EPI coverages; the vaccination compaign strategy has shown its effectiveness and safety, showing impact in the reduction of infection rates.
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PMID:[IMPACT OF THE IMMUNIZATION PROGRAM INTEGRATED TO THE EXPANDED IMMUNIZATION PROGRAM(EPI) IN HUANTA,1994-1997] 1214 May 82

Hepatocellular carcinoma (HCC) is one of the most fatal human malignancies, but the molecular mechanisms of hepatocarcinogenesis remain unclear. Although p53 mutations are frequently observed in Asian HCC, it is not a common event in Western HCC. Recent studies suggest that tumor suppressor genes (TSGs) can also be silenced through epigenetic disruption, such as promoter CpG island methylation, during carcinogenesis. To further understand the molecular mechanism of hepatocarcinogenesis, we have investigated the promoter methylation status of nine TSGs (SOCS-1, GSTP, APC, E-cadherin, RAR-beta, p14, p15, p16, and p73) in 51 cases of HCC using methylation-specific polymerase chain reaction. We found that 82% of HCCs had methylation of at least one TSG promoter. The most frequently methylated TSGs in HCC were: SOCS-1 (65%), GSTP (54%), APC (53%), E-cadherin (49%), and p15 (49%). Methylation of SOCS-1, GSTP, APC, E-cadherin, and p15 was more frequent in HCC than in nontumor liver (P < 0.05). Methylation of SOCS-1, GSTP, and p15 was also significantly more frequent in HCC than cirrhotic liver (P < 0.05). Although methylation of one or two genes could be seen in both nontumor and cirrhotic livers, 53% of the HCC cases had three or more TSG promoters methylated, in comparison to 0% in nontumor liver and 13% in cirrhosis (P = 0.001). Methylation of SOCS-1, APC, and p15 was more frequently seen in hepatitis C virus-positive HCC than hepatitis C virus/hepatitis B virus-negative HCC. Our data suggest that promoter hypermethylation of TSGs is a common event in HCC and may play an important role in hepatocarcinogenesis.
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PMID:Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. 1293 51

Hepatitis B virus (HBV) infection affects more than 2 billion people throughout the world. Among them, more than 240 million have chronic infection. Every year, 0.5-1.2 million people die of chronic hepatitis B virus infection (CHBVI), and approximately 60% of liver cancers are related to CHBI and subsequent liver cirrhosis (LC). These HBVI-related diseases impose a considerable economic burden as well as morbidity on patients, families, and society. Family and twin studies have indicated that the host genetic constitution greatly influences the clinical outcomes of HBV infection. During the past several years, genome-wide association studies (GWAS) have identified susceptibility variants for various HBVI-related diseases. Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance. However, whether there exists an association between HLA-DP variants and the progression of CHBVI remains to be determined. Thus, further study should focus not only on identifying more variants in HLA-DP that are associated with various HBVI-related diseases but also on characterizing any newly discovered functional variants at the molecular level. Further, given the complexity of CHBV infection and its progression, gene-gene and gene-environment interactions should also be taken into consideration. Moreover, because both smoking and alcohol affect HBV infection and progression, it is important to understand how these factors interact with genetics to influence HBV-related diseases.
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PMID:Association of variants in HLA-DP on chromosome 6 with chronic hepatitis B virus infection and related phenotypes. 2484 44