Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum concentrations of laminin and hyaluronate were assayed in 138 patients of liver disease with an enzymoimmunological method. There was a mild increase of hyaluronate level in patients with acute hepatitis (P < 0.05) and a significant increase of both serum laminin and hyaluronate concentrations in patients with chronic hepatic diseases, as compared with those in healthy controls (P < 0.001). Serum laminin and hyaluronate reached the highest levels in patients with liver cirrhosis. Comparing the results from a group of patients with liver cirrhosis with those from a reference group of patients with chronic active hepatitis, we obtained values for specificity, sensitivity, and diagnostic efficiency of 0.90, 0.90 and 0.90 respectively. The results suggested that quantification of serum laminin and hyaluronate may be a useful test to assess the degree of chronic liver injury and to diagnose liver fibrosis.
Zhonghua Nei Ke Za Zhi 1994 Feb
PMID:[The extracellular matrix and liver disease: a study with enzymoimmunological assay]. 807 Feb 90

Copper contents (Cu) in bodies and serum ceruloplasmin (Cp) were assayed in patients with liver cirrhosis (LC) and hepatocarcinoma (HCC) with atomic absorption and other methods. The results were shown as follows: 1. The mean levels of serum Cp and urine Cu in LC were higher than those of normal (P < 0.05 and 0.01). 2. Serum Cu and Cp levels were consistently high in HCC. Urine Cu level was also elevated and had positive correlation with that of serum Cu (r = 0.567, P < 0.01). 3. Cirrhotic liver Cu content was almost the same as that of pericarcinomatous liver Cu, being higher than that of normal and carcinomatous liver. 4. Hair Cu level in both LC and HCC was apparently lower than that of normal subjects. 5. Serum Cu level in patients with tumor more than 5 cm in size was higher than that in patients with tumor less than 5 cm (P < 0.05). 6. Serum Cu level decreased along with the reduction of tumor size after treatment. 7. Serum Cu and Cp levels may be used as markers for detection of HCC, especially for AFP-negative HCC. Serum Cu estimation is valuable in assessment of the therapeutic effect and prognosis in patients with HCC.
Zhonghua Nei Ke Za Zhi 1994 Feb
PMID:[The changes in copper contents and its clinical significance in patients with liver cirrhosis and hepatocarcinoma]. 807 Feb 91

In order to explore latent. HBV infection in primary hepatic carcinoma (PHC) and liver cirrhosis (LC), serum HBV X and S gene were tested with polymerase chain reaction in 40 cases of PHC and LC with both negative HBsAg and HBeAg. The positive rates for X and S gene were much the same. The S gene-positive cases were, however, slightly more than the X gene-positive ones. In the cases of PHC and LC with all the five serum immunologic markers negative HBV DNA was found in 56.3% (9/16) and 45.5% (5/11) of the cases respectively. Of those patients with positive anti-HBs or anti-HBe, HBV DNA was found in 4/8 and 1/4 of the cases respectively. It was shown that in the cases of PHC and LC with all the five markers-negative, about half of them seems to be still related with HBV infection. Some of the PHC and LC cases with positive anti-HBs or anti-HBe may also have low level of viral replication. Detection of HBV DNA with multiple genes is of help to identify more PHC and LC patients with latent HBV infection.
Zhonghua Nei Ke Za Zhi 1993 Mar
PMID:[Identification of latent HBV infection in primary hepatic carcinoma and liver cirrhosis with polymerase chain reaction]. 822 76

In order to know whether HBV antigen exists in extrahepatic tissue, we detected HBV antigen in liver and gallbladder tissue obtained from 31 cases with HBV chronic liver disease (17 active cirrhosis, 14 chronic hepatitis) by using polyclonal antibody and ABC method. All cases were diagnosed by biopsy (n = 12) or autopsy (n = 19), 25 were males and 6 females, the average age was 45.6 years. The results showed that in the liver tissue 30 cases were (96.77%) HBsAg positive and 15 cases (48.39%) HBcAg positive. In the gallbladder tissue 18 cases (58.06%) were HBsAg positive and 8 cases (25.81%) HBcAg positive. Although 26 cases had pathological changes in the gallbladder, the changes had no relation with the existence of HBV antigen. Their symptoms and signs were also not related with the existence of HBV antigen in the gallbladder. Among the 31 cases, 19 died. The cause of death was severe hepatic complication, but not the pathological change of the gallbladder. The results suggest that pathogenesis of HBV in extrahepatic tissue needs to be elucidated.
Zhonghua Nei Ke Za Zhi 1993 Aug
PMID:[Detection and significance of HBV antigen in gallbladder tissue]. 826 87

To explore the characteristics of hepatitis C in China, one hundred and sixty three cases of hepatitis C were followed for 8 years. The rates of abnormal alanine aminotransferase (ALT) were 100%, 73%, 57%, 37% and 28% in less than one, 1, 2, 5 and 8 years after the onset respectively. Abnormality of ALT might be persistent or fluctuating, and the latter type accounted for about 1/3 to 1/2 of the cases. The positive rates of anti-hepatitis C virus (HCV) were 56%, 93%, 94%, 96%, 97%, 93% and 83% in less than two, 2-6, 7-12 months and 1, 2, 5 and 8 years after the onset respectively. Negative conversion of anti-HCV was found only in a few patients whose ALT had returned to normal level and the rates of negative conversion for them were 10%, 8%, 16%, and 22% in 1, 2, 5 and 8 years after the onset. Positive rate of HCV-RNA, detected with nested PCR 8 years after the onset was 84% for patients who still showed positive anti-HCV and there was no significant difference between patients with abnormal (80%) and normal ALT (85%) levels. Genotype II accounted for 93% of the cases. No patient developed hepatocellular carcinoma or decompensated cirrhosis after a follow-up of eight years.
Zhonghua Nei Ke Za Zhi 1995 Aug
PMID:[An eight-year prospective study on 163 cases of hepatitis C]. 869 16

Liver biopsy and autopsy specimens of 153 cases, including 39 cases of acute severe hepatitis (ASH), 21 cases of subacute severe hepatitis (SSH), 11 cases of chronic severe hepatitis (CSH), 22 cases of active cirrhosis (AC), 20 cases of acute mild (AMH), chronic persistent (CPH) and active hepatitis (CAH), respectively, were immunohistochemically stained for proliferating cell nuclear antigen (PCNA) to compare the proliferative activity of hepatocytes by using labelling index (LI). LI is higher in CAH, SSH, and AMH than in AC and CSH (P < 0.01). In the latter, LI was completely negative in most of the specimens (25/33, 75.8%) and few scattered hepatocytes positive for PCNA were found in the remaining 8 cases (8/33, 24.2%) in the area next to the fibrotic septum and varied greatly in different pseudolobules. The results showed that the proliferative activity was very low in the AC and CSH. In some cases of ASH, the residual hepatocytes still kept prominent proliferating ability; it meant that the survived percentage would have been increased with regeneration of hepatocytes if those patients had not died early. In ASH and SSH, LI was significantly higher in patients who survived than in those who died (P < 0.01). The detection of PCNA in liver tissue with severe viral hepatitis is useful for prognostic evaluation.
Zhonghua Nei Ke Za Zhi 1995 Nov
PMID:[Expression of proliferating cell nuclear antigen in the liver tissue of hepatitis B patients]. 873 41

The purpose of this study was to elucidate the clinical significance of nitric oxide synthases (NOS), nitric oxide (NO) and tumor necrosis factor (TNF) in different types of ascites. NOS, NO and TNF in ascitic transudates of 21 patients with liver cirrhosis, ascitic exudate of 32 patients with liver cirrhosis and carcinogenesic ascites of 19 patients were measured by Griess, ELISA and colorimetric methods. Compares to the value in ascitic transudate of 21 patients with liver cirrhosis, NOS (7.32 +/- 3.13 nmol.min-1.g-1), NO (15.4 +/- 7.6 mumol/L) and TNF (331.7 +/- 121.2 mumol/L) in ascitic exudate of 32 patients with liver cirrhosis were significantly higher (P < 0.01). The NO (10.7 +/- 3.2 mumol/L) and TNF (185.6 +/- 84.1 mumol/L) in carcinogenesic ascites of 19 patients were between those in ascitic exudates and those in ascitic transudates of patients with liver cirrhosis (P < 0.05 or 0.01). The NOS activity was highest in carcinogenesic ascites. The decrease of 24h urine volume in patients with cirrhosis was relative to the increase of NO level in ascites. Those suggested that measurements of NOS, NO and TNF in ascites are helpful in differential diagnosis of ascites. The separation between NO level and NOS activity in ascites indicates that the ascites is carcinogenesis.
Zhonghua Nei Ke Za Zhi 1996 Nov
PMID:[Study of nitric oxide synthases, nitric oxide and tumor necrosis factor in different types of ascites]. 959 41

To elucidate the role of apoptosis in the pathological lesion of hepatitis B virus (HBV) infection, biopsied liver tissue specimens of 38 patients with chronic hepatitis B of varying severity were investigated with in situ immunohistochemistry and TUNEL test. Apoptotic hepatocytes were found to be rare, while the nuclei of many cells were positively stained with TUNEL, suggesting 3'-OH ends generated as the DNA was impaired. Of the 17 cases with mild lesion or without piecemeal necrosis, 14 were negative or weakly positive with both Fas and TUNEL test. Of the 7 cases with piecemeal and bridging necrosis, none was strongly positive. In the 14 cases with active hepatitis and early cirrhosis, strongly positive results with Fas were found in 9 and with TUNEL in 3 respectively. It is suggested that the cytotoxic T lymphocyte (CTL)-Fas-apoptosis mechanism was involved in the hepatocyte death of hepatitis B as well. The Fas expression, DNA damage and apoptotic cells distributed mostly in the piecemeal necrosis region, and the ballooning and the necrotic hepatocytes were also clustering in this region. As both the apoptosis and necrosis are mediated by CTL, they are closely related: while transducted by different ways, they occurred independently.
Zhonghua Nei Ke Za Zhi 1996 Nov
PMID:[Fas expression and DNA impairment of hepatocyte in chronic hepatitis B]. 959 43

To investigate the prognostic factors of primary liver cancer (PLC) and improve the long-term results, 1,248 cases of PLC were analysed. Univariate analysis demonstrated that discovery approach, staging of PLC, original gamma-GPT, resection, radical resection, original AFP, tumor size, tumor number, and tumor capsule have very significant effects on prognosis of PLC (all P < 0.001); cirrhosis, HBsAg, local resection, and tumor embolus in portal vein were also significant difference (all P < 0.05); age, sex, original AFP, hepatitis, and differentiation of PLC cells were no significant difference (all P > 0.05). Multivariate analysis demonstrated that original gamma-GPT, radical resection, tumor size, and tumor number were the most significant prognostic factors (all P < 0.001). Some aspects improving long-term survival were discussed.
Zhonghua Nei Ke Za Zhi 1996 Aug
PMID:[Prognostic factors of primary liver cancer]. 959 43

The aim of this study is to ascertain whether the formation of nitric oxide is argumented in patients with liver cirrhosis and its mechanism. 38 cirrhotic patients and 15 normal controls were studied. Higher plasma levels of NO2-/NO3- (stable end products of nitric oxide), endotoxin, tumor necrosis factor alpha (TNF alpha) and cyclic guanosine monophosphate (cGMP) were observed in patients with cirrhosis than in normal controls (P < 0.01, 0.01, 0.01, 0.05). The higher Child-Pugh, the higher plasma NO2-/NO3- level. The concentration of NO2-/NO3- had a positive correlation with that of endotoxin and TNF alpha (r = 0.481, P < 0.01; r = 0.351, P < 0.05). It is suggested that the production of nitric oxide is augmented and could be induced by endotoxin and TNF alpha. Execessive formation of nitric oxide may be related to hyperdynamic circulation in cirrhosis.
Zhonghua Nei Ke Za Zhi 1997
PMID:[Nitric oxide levels in cirrhotic patients]. 981 57


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