Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study is at establishing cirrhotic portal hypertension with common bile duct ligation in 9 mongrel dogs to measure the plasma catecholamine level. On the basis of experimental study, phentolamine, the alpha-adrenoceptor antagonist, was used to treat 14 patients with liver cirrhosis complicating bleeding from esophageal variceal rupture. The results had been shown that the levels of noradrenaline (NE) in both portal and inferior caval vein were increased more significantly in the cirrhotic stage than in the precirrhotic stage. The mechanism of the NE elevation might be due to increased release from enhancement of sympathetic nervous activity. Our clinical data have also been demonstrated that the effect of phentolamine on the 12 cases of variceal hemorrhage is markedly efficacious with no longer bleeding. Only 2 patients had showed no good reaction neither to phentolamine nor to pituiterin, eventually died of liver failure. It is conceivable that phentolamine has the same efficacy in treatment of esophageal variceal bleeding as pituitrin. But less side effect than the latter.
Zhonghua Nei Ke Za Zhi 1989 Sep
PMID:[Phentolamine in cases of liver cirrhosis with bleeding from esophageal variceal rupture]. 262 24

The recombinant protein C11 derived from the C region of HCV genome and C7 derived from the nonstructural region NS3 of the HCV genome were used in ELISA to study 442 cases of liver diseases, including chronic hepatitis, cirrhosis and hepatocellular carcinoma in Beijing District. It was found that HBV infection was more prevalent than HCV infection in this district. Both liver cirrhosis and hepatocellular carcinoma were more related to the superinfection of HBV and HCV rather than HBV infection alone or HCV infection alone. It is suggested that there may be some interaction between the HBV and HCV to worsen the prognosis of these patients.
Zhonghua Nei Ke Za Zhi 1994 Jan
PMID:[An analysis of HCV infection by using recombinant HCV antigen C11 and C7]. 751 37

The point mutation in the precore region of hepatitis B viral genome (nt83) was tested with the method of mispairing PCR-RFLP in 54 chronic hepatitis B patients all confirmed by liver biopsy. The over all detection rate of pre-C mutation was 66.7% and the detection rate of pre-C mutation in chronic active hepatitis patients was as high as 80.0%, being significantly higher than that in chronic persistent hepatitis (46.7%). The detection rate of pre-C mutation was 41.2% in hepatitis B e antigen (HBeAg) positive group and 63.3% in anti-HBe(+) group respectively. The detection rate in anti-HBe(+) patients with normal alanine transaminase activity was as high as 82.4%. During the period of follow up it was found that pre-C mutation may appear and disappear or may persist continually. The results suggested that pre-C mutation was extremely common in chronic hepatitis B virus (HBV) infection. The coexistence of the mutant type and wild type in the patients may be considered as the natural course of HBV chronic infection. Further study on the cause and effect relation between pre-C mutation and genesis of chronic active hepatitis and liver cirrhosis is urgently needed.
Zhonghua Nei Ke Za Zhi 1995 Apr
PMID:[A kinetic study of hepatitis B virus pre-C gene mutation]. 758

It has been shown that hepatitis B virus (HBV) X antigen (HBxAg) functioned as a transactivating element which can act on the enhancer of HBV in an in vitro system and elevate the transcriptional level of HBV. In this study we investigate the relationship between HBxAg expression and HBV replication in patients with chronic hepatitis B and cirrhosis. Rabbit IgG against recombinant HBxAg which was synthesized in E. coli were prepared and used for the detection of HBxAg. HBV DNA was amplified by polymerase chain reaction technique by using primers from HBx gene sequence. Liver tissue samples and sera from the patients were examined immunohistochemically for HBxAg and serologically for HBxAg/anti-HBx respectively. We focused on its expression in these samples in comparison with markers of HBV replication. It was found that in liver HBxAg was present in 72.7% of the patients with chronic active hapatitis (CAH) and 92.6% of those with cirrhosis, while the positivity rate of HBcAg in cirrhosis patients was only 47.8%. In the sera of the patients with CAH, chronic persistant hepatitis and cirrhosis HBxAg was present in 44.4%, 66.6% and 33.3% respectively. It was similar to that observed with HBeAg. Moreover in these HBxAg positive sera HBV DNA can also be detected. It was shown that higher rate of positivity of HBxAg was found in patients with replicative markers (serum HBeAg, serum HBV DNA or liver tissue HBcAg positive). Our results indicate that expression of HBxAg is closely correlated with HBV replication and HBxAg may be an important marker in chronic HBV infection.
Zhonghua Nei Ke Za Zhi 1995 Apr
PMID:[Analysis of hepatitis B virus X antigen expression in chronic hepatitis B and cirrhosis]. 758 1

Persistent infection with hepatitis C virus (HCV) is associated with chronic hepatitis and cirrhosis which may eventually develop into hepatocellular carcinoma (HCC). As far, the pathogenesis mechanism of HCC is unclear and nothing is known of the distribution, frequency or type of infected cells in HCC. One-step reverse transcription in situ polymerase chain reaction (ORT-PCRIS) to detect HCV RNA in HCC samples was developed in our laboratory. Liver tissues from 27 patients with HCC were investigated by this technique for frozen or paraffin-embedded sections. Meanwhile, HCV RNA in sera and extracts of specimens with HCC were assayed by RT-PCR. The positive rate of HCV RNA by ORT-PCRIS was 81.5% (22/27) in the peritumor liver tissues and 77.8% (21/27) in the tumor tissues, significantly higher than 29.6% (8/27) in sera and 37.0% (10/27) in the extreats of HCC by RP-PCR (P < 0.01). HCV RNA positive signals were found mainly in the nuclei of tumor cell, and mainly both the nuclei and cytoplasms in peritumor cells and mainly both the nuclei and cytoplasms in peritumor cells (P < 0.05). Positive granules of HCV RNA were much more in peritumor cells than in the tumor cells. Positive cells were scattered mainly on the point-type in the cancer tissues and on the diffusion-type in the peritumor tissues. Our findings suggest that ORT-PCRIS for detecting HCV RNA in the cell with HCC remarkably prior to traditional RT-PCR. HCV infection plays a relatively important role in determination of HCC development and perhaps HCV replication and its genomic RNA integration with hepatocyte DNA are involved in the course of the malignant transformation of hepatocytes.
Zhonghua Nei Ke Za Zhi 1994 Nov
PMID:[Detection of hepatitis C virus RNA in cells with hepatocellular carcinoma and its practical significance by in situ polymerase chain reaction]. 760 Aug 63

The aim of this study is to observe the changes of bile elements in patients with cirrhosis of liver and to analyse the relationship with stone formation. The gallbladder bile in 24 patients with cirrhosis of liver was obtained with aspiration during operation. The levels of lipids, bilirubin and various metal elements such as potassium, sodium, calcium, magnesium, copper, iron, and zinc in the bile were determined. Elevated unconjugated bilirubin (UCB) level (P < 0.02) and decreased levels of total bile acid (TBA) (P < 0.001), total cholesterol (TC) (P < 0.001), phospholipids (PL) (P < 0.05) and bile viscosity (P < 0.001) were found. The levels of potassium, magnesium, copper and zinc in the bile decreased (all P values less than 0.001), while the level of iron increased (P < 0.02) significantly in cirrhotic patients. The results showed that there is an obvious tendency for gallbladder bile in cirrhotic patients to form pigment stones.
Zhonghua Nei Ke Za Zhi 1994 Nov
PMID:[Changes in lipids, bilirubin and metal elements in the gallbladder bile in patients with cirrhosis of the liver]. 760 Aug 68

Tumor necrosis factor alpha (TNF alpha) was measured with an enzyme-linked immunosorbent assay. TNF alpha levels in peripheral blood of patients with twenty-one cases of chronic persistent hepatitis (7.3 +/- 9.5 micrograms/L), fourty-two cases of chronic active hepatitis (15.4 +/- 31.1 micrograms/L), one hundred and six cases of liver cirrhosis (11.1 +/- 17.7 micrograms/L) and one hundred and ten cases of parimary hepatocellular carcinoma (10.9 +/- 13.3 micrograms/L) was significantly increased when compared with normal controls (4.3 +/- 2.9 micrograms/L) (P < 0.01). There was significant correlation between tumor necrosis factor alpha levels and ALT elevation and also between TNF alpha levels and bilirubin contents more than 100 mumol/L in chronic hepatitis patients. Tumor necrosis factor alpha levels was also significantly in HBV concomitant with HCV and/or HDV infection than in HBV infection alone. There was no correlation in tumor necrosis factor alpha levels and AFP concentrations. These findings show that tumor necrosis factor participates in the activity process of liver disease.
Zhonghua Nei Ke Za Zhi 1994 Oct
PMID:[Tumor necrosis factor alpha levels in patients with chronic liver diseases and its relationship to pathogenesis]. 771 14

The thickness of the wall of the portal vein trunk (PVT) was determined with B-mode ultrasonography in 82 patients of schistosomiasis, with hepatic fibrosis, 35 cases of schistosomiasis without hepatic fibrosis, 30 cases of post-hepatitis cirrhosis and 32 healthy subjects. It was shown that the wall thickness of PVT increased in all the patients with schistosomiasis. The thickness in patients of schistosomiasis with hepatic fibrosis was markedly increased as compared with the other three groups (P < 0.01 in all). The magnitude of increase of the wall thickness correlated well with the severity of the pathological change of hepatic fibrosis. It was also noted that change of wall thickness of PVT was not only accompanied by change in hyaluronate and hydroxyproline estimation, but also closely correlated with the international criteria of ultrasound parameters for assessment of pathological changes of schistosomiasis (rs = 0.839, rs = 0.748). Measurement of the wall thickness of PVT is, therefore, a valuable clinical method for diagnosing schistosomiasis with hepatic fibrosis and determining the severity of its pathological change.
Zhonghua Nei Ke Za Zhi 1994 Dec
PMID:[Determination of the thickness of the wall of portal vein trunk in patients of schistosomiasis japonica with hepatic fibrosis and its clinical significance]. 776 38

In 46 patients with decompensated posthepatitis cirrhosis, various clinical manifestations resulted from changes of bone density were noted. The relation between the changes of bone density and the level of blood calcium, blood phosphorus and alkaline phosphatase (AKP) as well as the metabolism of vitamin D was studied. It is shown that: (1) Bone mineral content (BMC) in the cirrhosis group decreased as compared with that in a control group (P < 0.05). (2) Blood calcium and phosphorus level decreased, whereas AKP level increased significantly (P < 0.01) in the cirrhosis group. (3) When BMC decreased, blood calcium and phosphorus level also decreased significantly (P < 0.01). When the condition of cirrhosis deteriorated, these changes became more obvious. The reasons may be: (1) Disorder of vitamin D metabolism in cirrhosis. (2) Decrease of calcium absorption by intestine. (3) Nutritional disturbance. It is suggested that the occurrence of bone rarefaction in cirrhosis was due to multiple factors.
Zhonghua Nei Ke Za Zhi 1994 Dec
PMID:[A clinical analysis on the variance of bone density in patients with cirrhosis]. 776 39

Acute and chronic effect of Radix Angelicae Sinensis (RAS) on serum gastrin levels in patients with cirrhosis were investigated. The results showed that after intravenous perfusion of RAS, serum gastrin levels of inferior vana cava, hepatic and peripheral veins were significantly decreased. After long-term administration of the agent, the level fell nearly to that of control subjects. It is suggested that the effect of reducing serum gastrin level by RAS may improve portal hemodynamics and be beneficial for portal hypertensive gastroduodenal mucosal lesions in cirrhosis.
Zhonghua Nei Ke Za Zhi 1994 Jun
PMID:[Effect of radix Angelicae sinensis on serum gastrin levels in patients with cirrhosis]. 786 24


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