Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The usefulness of Doppler blood flow ultrasonography in diagnosis of some liver diseases was investigated. Normal subjects and patients with AH and CPH had no blood flow signal on their abdominal wall and their femoral veins were normal. One (5%) of 20 patients with CAH was found to have blood flow signals on abdominal wall and the direction of the flow was normal, suggesting that collateral circulation has been established due to portal hypertension as a result of liver cirrhosis. 12 out of 20 cases of liver cirrhosis with no varices on abdominal wall had blood flow signals on their abdominal wall and the direction of the flow was normal. One case of Budd-Chiari syndrome with occlusion of hepatic vein and inferior vena cava showed blood flow signal on his abdominal wall and the direction of the flow was abnormal. One case of constrictive pericarditis showed abnormal blood flow in the femoral veins. In conclusion, this method is highly useful for the diagnosis and differential diagnosis of portal hypertension of cirrhosis and Budd-Chiari syndrome. It is also of help for the diagnosis of pericarditis and some other vascular deformity.
Zhonghua Nei Ke Za Zhi 1991 Sep
PMID:[Usefulness of Doppler blood flow ultrasonography in diagnosis of liver diseases]. 183 17

The rate of micronucleus formation in lymphocytes was determined in 42 patients (including 10 acute icteric hepatitis B, 15 chronic active hepatitis B (CAH), 8 liver cirrhosis and 9 liver cancer) and 13 normal subjects. The results showed that the rate of micronucleus formation in lymphocytes in the patients with CAH (12.267 +/- 5.298%), liver cirrhosis (12.375 +/- 8.551%) or liver cancer (19.444 +/- 13.324%) was markedly higher than that in those with acute icteric hepatitis B (5.400 +/- 1.430%) or normal subjects (3.308 +/- 1.284%) (P less than 0.01). The rate of micronucleus formation in lymphocytes is higher in the liver cancer group than that in the CAH group or cirrhosis group (P less than 0.05). The rate of presence of two or more micronuclei in the lymphocytes was obviously higher in the liver cancer group (3.667 +/- 4.743%) than that in the liver cirrhosis group (1.500 +/- 1.690%), CAH group (1.467 +/- 1.807%), acute icteric hepatitis B group (0.600 +/- 1.075%) or healthy group (0.462 +/- 0.660%) (P less than 0.01 or less than 0.05). This method is much simpler than the measurement of chromosomal damage, and its reliability is as good as the latter. Measurement of micronuclei in lymphocytes can reflect the degree of liver damage in patients with the infection of hepatitis B virus. It may be used as the subclinical marker of the patients with liver cancer too.
Zhonghua Nei Ke Za Zhi 1991 May
PMID:[Determination of the rate of micronucleus formation in lymphocytes in liver diseases and its clinical significance]. 187 42

In this study, HBsAg, HBcAg and HBV DNA in myeloid cells of 57 patients with hepatitis have been examined by using ABC staining method. The results show that in the myeloid cells of 54 patients with positive HBVM in serum, there are 4 cases with HBV positive antigen, HBcAg has been found in a case of acute hepatitis and HBsAg in a case of chronic hepatitis and a case of liver cirrhosis respectively, HBsAg and HBcAg were found simultaneously in another case of liver cirrhosis. Nothing has been found the myeloid cells of 3 cases with negative HBVM in serum. All these findings suggest that myeloid cells are probably another breeding ground for duplicating HBV.
Zhonghua Nei Ke Za Zhi 1991 Jan
PMID:[The conditions of HBV infection in myeloid cells in patients with hepatitis]. 203 91

Changes in serum procollagen-III-peptide (PIIIP) and intravenous tryptophan tolerance test (ITT) were studied in 121 patients with liver cirrhosis during a follow-up period of up to 18 months. The patients received either nifedipine (31 cases, 60 mg/day), verapamil (28 cases, 120 mg/day), cinnarizine (29 cases, 150 mg/day) or tetrandrine (33 cases, 150 mg/day). The significant changes were found in ITT in any of the four drugs administrated for over three months. Serum PIIIP concentration decreased significantly in patients under tetrandrine therapy for 18 months (12.06 +/- 3.91 ng/ml vs 16.57 +/- 5.69 ng/ml before treatment). These data suggest that tetrandrine therapy may have favourable effects on hepatic fibrosis and improvement of liver function in liver cirrhosis.
Zhonghua Nei Ke Za Zhi 1990 Aug
PMID:[Significance of serum procollagen-III-peptide in reflecting the therapeutic effects of calcium-channel blockers on hepatic fibrosis]. 208 11

Beta 2-Microglobulin expression on hepatocyte membrane was studied in 117 liver biopsies from patients with acute and chronic hepatitis B and in 11 subjects with normal liver function, using immunohistochemical PAP method. In normal liver beta 2-microglobulin could not be detected on hepatocyte membrane, compared with that in subjects with normal liver, in asymptomatic HBsAg carrier and in patients with chronic persistent hepatitis, there is significant enhancement of beta 2-microglobulin expression in patients with acute mild hepatitis and chronic mild active hepatitis. Beta 2-Microglobulin expression in patients with chronic active hepatitis with moderate to severe activity and cirrhosis has a significant enhancement, when compared with acute mild hepatitis and chronic mild active hepatitis. Moreover, location of beta 2-microglobulin expression on hepatocyte membrane was associated with lesion of hepatocytes. Enhanced expression of beta 2-microglobulin on hepatocyte membrane in acute and chronic hepatitis B probably reflects enhanced display of HLA-ABC antigens and may influence the course of hepatitis B virus infection by increasing susceptibility of T cell-mediated hepatocytelysis.
Zhonghua Nei Ke Za Zhi 1990 Feb
PMID:[A study of the relation of the expression of beta-microglobulin and hepatocytic lesions in hepatitis B]. 220 29

Six cases of cyanosis and digital clubbing caused by liver cirrhosis were reported. The mean levels of PaO2 and PaCO2 were 6.4 +/- 0.8 kPa (48.3 +/- 6.2 mmHg) and 3.9 +/- 0.8 kPa (29.5 +/- 6.1 mmHg) respectively. The cause of cyanosis and digital clubbing in liver cirrhosis was discussed. Abnormal intrapulmonary shunting (IPS), which was proved in 4 cases by whole-body radionuclide scanning with 99mTc-MAA, is suggested as the major cause of cyanosis in liver cirrhosis. Clinically IPS is usually associated with debilitating conditions characterized by hyperventilation, abnormality of lung diffusion and orthodeoxia or platypnea. The authors suggest that whole-body radionuclide scanning with 99mTc-MAA may be performed for establishing IPS if liver cirrhosis is highly suspected to be the cause of severe hypoxemia.
Zhonghua Nei Ke Za Zhi 1990 Feb
PMID:[Diagnosis of cyanosis and digital clubbing caused by liver cirrhosis]. 220 37

To clarify the correlation of hepatitis D virus (HDV) infection and viral replication in liver diseases, the authors detected HDV RNA and serological HDV markers in serum from 285 patients with hepatitis B and 45 asymptomatic carriers of HBsAg. With dot blot hybridization, serum HDV RNA was detected in 8.8% (29/330) of the patients with HBV infection. The positive rate of HDV RNA in fulminant hepatitis was higher than that in benign hepatitis (15/74 vs 3/47, P less than 0.05). 10 of the 139 patients with chronic active hepatitis and 1 of the 6 cases with cirrhosis were positive for HDV RNA. However, all of the 19 cases with chronic persistent hepatitis and 45 asymptomatic carriers of HBsAg were negative fo, HDV RNA. Serological HDV markers, HDAgr anti-HD and IgM-anti-HD, were determined with ELISA. HDV RNA was detected in all of the serum samples with positive HDAg and/or IgM-anti-HD, in 15 of the 26 cases with positive-anti-HD and in 8 cases without HDV markers. Our results showed that 40 of the 330 patients with HBsAg were infected by HDV. This investigation suggests that HDV is one of the etiological factors for fulminant hepatitis and chronic active hepatitis.
Zhonghua Nei Ke Za Zhi 1990 Jun
PMID:[Hepatitis D virus RNA in serum from patients with hepatitis B]. 226 30

Serum alpha-L-fucosidase (AFU) was determined in 33 patients with hepatocellular carcinoma (HCC), 4 with secondary metastatic liver cancer, 61 with various liver diseases, 12 with gastrointestinal tumor and 50 healthy controls. The results showed that AFU level was significantly higher in HCC (14.48 +/- 5.77) than that in the controls (3.33 +/- 0.72) and in patient with other diseases (P less than 0.01). Serum AFU level was also increased in fulminant hepatitis (8.96 +/- 3.99), acute hepatitis (8.94 +/- 4.94) and chronic hepatitis (7.27 +/- 2.58), P less than 0.01 or 0.05. There was no significant difference in AFU level between the controls and patients with secondary metastatic liver cancer (6.25 +/- 0.84), cirrhosis (6.30 +/- 3.17), gastrointestinal tumor (4.43 +/- 1.64), liver hemangioma and liver abscess (4.86 +/- 2.22). A level exceeding 10.5u was a useful marker for the diagnosis of HCC with 78.8% sensitivity and 90.0% specificity. The diagnostic positivity was 81.8% in low AFP producing HCC, whereas 93.9% in those with elevated AFP. Our data indicate that serum AFU is a useful tumor marker for HCC, particularly in detection of AFP-low or negative HCC patients.
Zhonghua Nei Ke Za Zhi 1989 Jul
PMID:[A preliminary study on serum alpha-L-fucosidase assay in the diagnosis of hepatocellular carcinoma]. 248 Feb 10

Antipyrine (AP) clearance was determined in 23 cases with liver cirrhosis (LC), 12 with chronic active hepatitis (CAH), 12 with hepatocellular carcinoma (mcHCC), 20 with non-hepatic diseases and 70 healthy controls. ICG Clearance was performed simultaneously in 9 cases of them. The results showed that AP clearance was significantly decreased in patients with LC and moderately decreased in CAH and HCC, its diagnostic sensitivity in LC was significantly higher than that of GPT. The significant positive correlation between the AP and ICG clearance was noted and AP clearance also well correlated with serum albumin level and prothrombin time. It is suggested that AP clearance may be used as a quantitative test to determine the reserve capacity of liver and as a substitutive test for ICG clearance.
Zhonghua Nei Ke Za Zhi 1989 May
PMID:[Evaluation of antipyrine clearance in chronic liver diseases]. 255 53

The authors collected 41 cases of cirrhosis in native Tibetans with pathological verification. It is found that 60.98% of the cases were alcoholic cirrhosis, with an incidence significantly higher than that of 7.6% reported in the inland (P less than 0.01). 74.19% and 20% of the cirrhosis in male and female patients respectively were alcoholic, while 50% of the cirrhosis in the female were due to malnutrition. Among the Tibetan cirrhotics 12.2% was due to hepatitis and 4.88% each to hydatid disease and tuberculosis. The average age of these cirrhotics was 47.05. The frequent occurring age was between 41-50 (about 41.46%). The Tibetan cirrhosis in peasants and herdsmen were 51.28%. At the first admission, 84.49% got jaundice and 90.2% got ascites. These percentages were higher respectively than 43.2% and 50.5% from the Lanzou report (P less than 0.01). Ascites was serious, portal vein expanded, but splenomegaly were merely 17.07% (normal were 82.93%). These spleens expanded just a little, macrosplenopathy was not found.
Zhonghua Nei Ke Za Zhi 1989 Sep
PMID:[Analysis of the etiology and clinical characteristics of Tibetan cirrhosis in Tibet]. 262 23


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