Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatocellular carcinoma (HCC) is the most prevalent primary liver tumor that affects the world population. Liver cancer inevitably causes great harms and its treatment is extremely difficult. Its development is related to the existence of chronic liver injury, such as in cirrhosis. Cancer is a disease related to the process of inflammation so, research with anti-inflammatory agents has been performed for the development of anti-tumor drugs. Fructose-1,6-bisphosphate (FBP), a metabolite of the glycolytic route, has shown anti-inflammatory actions. The purpose of this study is to investigate the effect of FBP on HepG2 cells growth and inflammatory parameters. Results showed that FBP decreased the proliferation of HepG2 cells through trypan blue assay, without causing necrosis, shown by the intracellular release of LDH. By flow cytometry, we observed a significant IL-8 decrease which is closely related to the tumoral progression and chemotherapeutic resistance, especially in HCC. Then, we found, by RT-PCR, a high expression level of pro-apoptotic protein, such as Bax and p53, and decreased the expression levels of anti-apoptotic proteins, like Bcl-2 suggesting apoptosis. Finally, our results showed that FBP can be a potential therapeutic agent to slow the progress of HCC.
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PMID:Fructose-1,6-bisphosphate decreases IL-8 levels and increases the activity of pro-apoptotic proteins in HepG2 cells. 2824 45

Spontaneous Bacterial Peritonitis (SBP) is a frequent and severe complication in patient with cirrhosis and ascites due to CLD with high mortality rate (20%-40%). SBP causes an inflammatory reaction resulting in an increased number of PMNs in ascitic fluid. It was reported that diagnosis of SBP is established when the ascitic fluid PMN count is greater than 250 cells/mm3 Lysis of the PMNs during transport to the laboratory, may occur which may lead to false negative results. This study evaluated the*usefulness of some recent parameters for diagnosis of SBP that can be used for future development of a rapid bedside test. Identifying a sensitive marker that can be used for rapid diagnosis of SBP in cirrhotic patients will have important clinical and economic consequences for this group of patients and also for clinicians involved in their cares. This study was conducted on 100 patients with ascites admitted to Tropical Medicine department, Al-Azhar University.Hospitals in the period from January 2015 to August 2015. The results showed that there was a highly significant positive correlation between ascetic fluid LAF level and neutrophils in ascitic fluid in cases of SBP, Also there wasopositive correlation between ascetic fluid LAF and ascetic fluid LDH (p value<0.001).
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PMID:THE PREDICTIVE VALUE OF SOME RECENT PARAMETERS FOR DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS. 3015 40


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