Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023890 (
cirrhosis
)
42,195
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
As an essential member of the Polycomb group (PcG) proteins,
chromobox homolog 7
(
CBX7
) is found deregulated in some human cancers, and is thought to be a contributing factor in carcinogenesis. However, the expression and role of
CBX7
in hepatocellular carcinoma (HCC) is still not well characterized.
Materials and Methods:
The levels of the
CBX7
protein were quantified in 75 paired HCC and adjacent nontumor tissues by immunohistochemistry; comparisons were made using McNemar's chi-square test. The Kaplan-Meier estimate was used for survival analysis.
Results:
We found that the expression of
CBX7
in HCC tissues was significantly lower than that of adjacent nontumor tissues. In addition, decreased
CBX7
expression levels were correlated with
liver cirrhosis
in HCC patients. Furthermore, the survival times of HCC patients who were
CBX7
-expression-negative were shorter than HCC patients who were
CBX7
-expression-positive.
Conclusion:
Our results show that downregulation of
CBX7
is related to HCC progression and a poor prognosis in HCC patients.
...
PMID:Downregulated Expression of Chromobox Homolog 7 in Hepatocellular Carcinoma. 3099 Mar 38
