Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although newer and more effective treatments are now available for hepatitis C virus (HCV) infection, non-HCV viral hepatitis remains an important cause of liver disease, especially among HIV-infected individuals. Hepatitis B virus (HBV) is the leading cause of cirrhosis worldwide, and approximately one-quarter of patients with cirrhosis develop decompensated liver disease within 5 years. Initial treatment for chronic HBV infection includes peginterferon alfa, entecavir, and tenofovir. Approximately 15 million of the estimated 350 million individuals with chronic HBV infection have evidence of exposure to hepatitis D (delta) virus (HDV), which requires hepatitis B surface antigen for transmission and packaging. HBV/HDV coinfection is associated with more severe acute hepatitis and higher mortality than acute HBV monoinfection. Chronic coinfection is associated with a higher risk of cirrhosis and decompensated liver disease. The mainstay of treatment for HDV infection is peginterferon alfa for at least 48 weeks. Cases of hepatitis E virus (HEV) infection in HIV-infected persons have been reported. HEV infection can become chronic in immunosuppressed patients, and chronic infection is associated with rapid development of cirrhosis. There are no established guidelines for treating HEV infection in HIV-infected persons. This article summarizes a presentation by Jennifer Price, MD, at the IAS-USA continuing education program held in San Francisco, California, in June 2013.
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PMID:An update on hepatitis B, D, and E viruses. 2453 56

Treatment of hepatitis C virus (HCV)-infected patients with cirrhosis remains challenging. Biopsy to stage liver fibrosis remains the standard for identifying cirrhosis, although the noninvasive technique of transient elastography is promising in this regard. Cirrhosis is categorized as compensated or decompensated, with the latter characterized by ascites, hepatic hydrothorax, bleeding varices, hepatic encephalopathy, and hepatorenal syndrome. In the interferon alfa treatment era, patients with compensated cirrhosis have been candidates for interferon alfa-based treatment, whereas those with decompensated cirrhosis have been treated with caution and only at a tertiary care or transplant center. New interferon alfa-free regimens offer safer treatment alternatives to patients with cirrhosis. Response to interferon alfa-based therapy alone and in combination with the first-generation HCV protease inhibitors boceprevir or telaprevir for the treatment of HCV genotype 1 infection has been poorer in patients with cirrhosis than in those without. With regimens that include newer direct-acting antivirals, response rates are tremendously improved for patients with cirrhosis but still slightly lower than those for patients without cirrhosis. As new regimens enter use outside of clinical trials, optimizing efficacy for patients with cirrhosis will be an important goal. Patients with cirrhosis must be taught to practice liver wellness following HCV cure, to lower the risk of progression of their liver disease. Risk of hepatocellular carcinoma also persists in patients with cirrhosis even if cure of HCV infection is achieved. The risk of these complications is dramatically reduced with cure of HCV infection through antiviral treatment. This article summarizes a presentation by Andrew J. Muir, MD, MHS, at the IAS-USA continuing education program held in Atlanta, Georgia, in September 2013.
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PMID:Cirrhosis in hepatitis C virus-infected patients: a review for practitioners new to hepatitis C care. 2539 70

All patients with HIV infection should be screened for hepatitis B virus (HBV) infection. Preventive HBV vaccination is less effective in HIV-infected patients than in those without HIV infection. Emtricitabine, lamivudine, and tenofovir disoproxil fumarate (tenofovir) each have activity against HIV and HBV. In HBV/HIV-coinfected patients, if HBV or HIV treatment is needed, it should be initiated with tenofovir and emtricitabine or tenofovir and lamivudine as the nucleoside analogue reverse transcriptase inhibitor backbone of a fully suppressive antiretroviral regimen. If HBV treatment is needed and tenofovir cannot be used safely, entecavir is recommended in addition to a fully suppressive antiretroviral regimen. Initiation of treatment for HBV infection is based on the presence of cirrhosis and on HBV DNA level, alanine aminotransferase level, and biopsy results. Current HBV treatments are associated with low functional cure rates. This article summarizes a presentation by Kenneth E. Sherman, MD, PhD, at the IAS-USA continuing education program held in San Francisco, California, in March 2015.
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PMID:Management of the Hepatitis B Virus/HIV-Coinfected Patient. 2651 94

Direct-acting antiviral (DAA) regimens now allow treatment of previously untreated or treated (including prior DAA failures) patients with chronic hepatitis C virus (HCV) infection with 8 or 12 week regimens, largely without the use of ribavirin. Newer next-generation pan-genotypic regimens with activity against resistance-associated substitutions include glecaprevir/pibrentasvir (GLE/PIB), a combination of a nonstructural protein (NS)3 protease inhibitor and an NS5A inhibitor, and sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX), a combination of an NS5B polymerase inhibitor, NS5A inhibitor, and NS3 protease inhibitor. Both regimens have indications in DAA-experienced patients. GLE/PIB is approved for treatment of patients with genotype 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis and for the treatment of patients with genotype 1 infection previously treated with a regimen containing an NS5A inhibitor or an NS3/4A protease inhibitor, but not the combination. SOF/VEL/VOX is approved for retreatment of patients without cirrhosis or with compensated cirrhosis with genotype 1, 2, 3, 4, 5, or 6 infection previously treated with an NS5A inhibitor-containing regimen, or with genotype 1a or 3 previously treated with a SOF-containing regimen without an NS5A inhibitor. This article summarizes an IAS-USA webinar given by Susanna Naggie, MD, MHS, on August 30, 2018.
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PMID:Treating HCV Infection: It Doesn't Get Much Better Than This. 3064 83

Hepatitis B virus (HBV) infection is a lifelong dynamic disease that can be controlled with treatment but cannot yet be cured. Risk of end-stage liver disease and hepatocellular carcinoma (HCC) increases with ongoing inflammation and HBV viremia. Initial treatments consist of tenofovir or entecavir. Patients who require treatment include those with chronic hepatitis, cirrhosis, HCC, or HIV coinfection; patients receiving immunosuppressive treatments; and women in the third trimester of pregnancy who have elevated HBV DNA level. A number of virologic and host immune approaches are being investigated with the aim of achieving HBV eradication. This article summarizes an IAS-USA webinar given by Marion G. Peters, MD, on June 14, 2018.
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PMID:Hepatitis B Virus Infection: What Is Current and New. 3064 84