Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023890 (
cirrhosis
)
42,195
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Morphine hydrochloride
10 mg suppository was given every 6 hours in a patient with hepatoma and
hepatic cirrhosis
. The serum morphine concentration increased continuously until 4 hours after the second administration, and peak level showed 17 ng.ml-1. Morphine-6-glucuronide and morphine-3-glucuronide in the serum persisted at low levels of 32.4 ng.ml-1 and 169 ng.ml-1 respectively. Three days after the administration, morphine suppository had to be discontinued because of severe nausea and vomiting. It should be noticed that a remarkable reduction in morphine metabolism may occur and this may lead to unexpected high serum concentration of morphine in a patient with hepatic dysfunction.
...
PMID:[A patient with hepatoma and hepatic cirrhosis showing abnormally high blood morphine concentration after periodical suppository administration]. 830 46
