Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cystic fibrosis was diagnosed after age 13 in 25 patients. All had an elevated sweat chloride and either a sibling with cystic fibrosis or typical pulmonary infection or digestive symptoms caused by exocrine pancreatic deficiency. Fourteen had long-standing pulmonary or digestive symptoms. In contrast, four of eight patients whose symptoms began after age 13 presented with biliary cirrhosis. Three male patients were asymptomatic at diagnosis. Opacification of all paranasal sinuses was found in all patients examined radiologically. At diagnosis, pulmonary-function testing showed obstructive changes in 19 patients and sputum cultures showed Pseudomonas aeruginosa in 15 patients. Delayed menarche in five of seven female patients and infertility in the asymptomatic male patient (two of whom were found to have aspermia) could have led to earlier diagnosis. Teenagers and young adults with long-standing pulmonary or digestive symptoms, unexplained cirrhosis, aspermia, or a sibling with cystic fibrosis should be sweat-tested by pilocarpine iontophoresis.
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PMID:Cystic fibrosis diagnosed after age 13. Twenty-five teenage and adult patients including three asymptomatic men. 88

In a few alleged rape cases, examination of vaginal secretions will be negative for spermatozoa but positive for significant levels of prostatic acid phosphatase. These laboratory results can occur in cases in which the accused is known to have sired children. The most common etiologic factors for the aspermia are vasectomies and chronic alcoholism with or without cirrhosis.
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PMID:Prostatic acid phosphatase, aspermia, and alcoholism in rape cases. 739 97

Administration of alcohol in the food of male white rats for 2 or more months, in daily quantities of 0.25 to 2.25 cc., results almost constantly in the appearance of marked degenerative alterations in the testicles. These changes affect the steps of spermatogenesis in inverse order to their occurrence, so that for some time before sterility and complete aspermia result, the animal is producing spermatozoa with all possible degrees of abnormality and deficiency. The possible relation of this abnormal spermatogenesis to the production of defective offspring is obvious. Individual rats show marked differences in the degree of change produced by equal amounts of alcohol. The fibrous, interstitial, and vascular elements of the testicle are not affected, except for intertubular edema compensating for tubular atrophy. These experimental observations harmonize with the necropsy findings in human alcoholics. No other tissue was found to be noticeably affected by the alcohol; especially to be remarked is the absence of cirrhosis or fatty infiltration in the liver.
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PMID:THE EFFECT OF ALCOHOL ON THE REPRODUCTIVE TISSUES. 1986 82