Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Increase in the production of hepatic lymph is a compensatory mechanism known to occur in cirrhosis, neoplasia of the liver, biliary obstruction, and right-sided cardiac decompensation with elevated hepatic venous pressure. In hepatic lymphostasis, dilated hepatic lymphatics are reflected on CT as low attenuation rims--perivascular lucencies (PVLs)--surrounding the portal veins and the intrahepatic vena cava. In this study, CT scans of the livers of normal controls and patients in each of the four disease categories mentioned above were evaluated for the presence of PVLs; the presence/absence of PVLs was correlated with other CT findings and various biochemical and pathophysiologic parameters. The PVLs were seen with some frequency in patients in each of the four disease categories (12-52%) but in none of the normal controls. In patients with tricuspid incompetence, the presence of PVLs correlated perfectly with the presence of mottled enhancement of the hepatic parenchyma (evidence of sinusoidal stasis). The presence of PVLs was associated with elevation of certain biochemical parameters, but no common biochemical marker was observed across the disease categories. Perivascular lucencies on CT reflect altered hepatic lymphatic dynamics; in the absence of impaired efferent lymph drainage, they reflect increased lymphatic flow. However, the sensitivity of the finding--the relationship of the presence/absence of PVLs on CT to the degree of alteration of the lymphatic dynamics--has yet to be assessed.
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PMID:Increased lymphatic flow from the liver in different intra- and extrahepatic diseases demonstrated by CT. 206 65

Intestinal fat absorption was examined in rats with CCl4-induced liver cirrhosis. Marked lymphangiectasia of the small intestine was observed in rats after CCl4 was given subcutaneously biweekly for 10--12 weeks. Intestinal epithelial uptake of linoleic acid administered in the loop was not impaired, but accumulation of lipid droplets in the intestinal epithelial cells and disturbed lymphatic transport of absorbed fat were observed in these rats. These data suggest that lymphostasis of the intestine may play an important role in fat malabsorption in liver cirrhosis.
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PMID:Lymphatic role in the pathogenesis of fat malabsorption in liver cirrhosis in rats. 714 Apr 88