Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diaphragm peritoneum from 12 operated patients and 34 patients who died from liver cirrhosis with or without ascites was studied by means of light microscopy and electron transmission and scanning microscopy. Considerable lesions are found in the peritoneum: cuboidization of mesothelial cells, basal membrane thickening, dilation of stomata, lymphatic lacunae and collectors lumina. Liver cirrhosis with ascites is frequently followed by lymphatic vessels thrombosis and firm attachment of the diaphragm to the liver resulting in the inhibition of the ascitic liquid elimination. Thus both the enhancement of liquid transudation into the abdominal cavity and the disturbance of the drainage function of the diaphragm peritoneum take place.
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PMID:[Routes of resorption of peritoneal fluid in the diaphragm in liver cirrhosis (morphologic study)]. 185 76

With increased formation of lymph the lymphatic vessels of the liver are detectable on X-ray and can be assessed. Lymphatic vessels of the portal areas and Glisson's capsule and the pathways of the efferent extrahepatic lymphatics are described. Examples of pathological hepatograms in cirrhosis are presented.
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PMID:[Patho-anatomy of lymph vessels of the liver from a roentgenologic viewpoint]. 647 58

From 1975 to 1982, central lymph drainage was performed in our hospital, on 12 infants with atresia of the intrahepatic bile ducts. The greater omentum was used for the drainage. It was mobilized and attached to the incised hilar lymph nodes and lymphatic vessels of the hepatic-duodenal ligament and to the decapsulated duodenum. In two children, this method was combined with Kasai's operation. These two children developed cirrhosis of the liver. Only one of the other 10 children, who underwent our own procedure, has developed cirrhosis so far. The remaining 9 children show no signs of liver damage.
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PMID:[Omento-porto-duodeno-pexy in the treatment of bile-duct atresia and hypoplasia in infants]. 664 6

Morphological study of the hepatic lymph vessels in 16 patients with diseases of the liver and biliary tract and the thoracic duct in individuals of different ages showed that the number and diameter of the lymphatic vessels and the diameter of the thoracic duct increase in the phase of inflammation, Proliferation of connective tissue in cirrhosis reduces the number of lymph vessels, induces valvular incompetence in the thoracic duct attended by ascites. Sixteen patients with diseases of the liver and biliary tract underwent operation for drainage of the thoracic duct. Biochemical parameters and the flow of lymph indicated that the diminished lymph issue is attended on the second day by decrease of the intoxication indices by one third, which is revealed by endotoxin--bile acids, bilirubin, the liver reduces in size and pruritus disappears. The results of the study substantiate the operation for drainage of the thoracic duct and show its importance as a method for the prevention of hepatic insufficiency and for detoxification.
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PMID:[Substantiation of the thoracic duct drainage in diseases of the liver and biliary tract]. 783 40

Succinylated wheat germ agglutinin, specified by the amino sugar beta(4)-N-acetylglucosamine, bound frequently to the endothelial cells of the hepatic arterial branches and small vessels of the peribiliary capillary plexus, while it did not bind to the endothelial cells of venous vessels such as portal vein branches and hepatic venous radicles, nor to lymphatic vessels. Sinusoidal endothelial cells were also negative for succinylated wheat germ agglutinin. Proliferating small vessels in the enlarged portal tracts and fibrous septa in patients with extrahepatic biliary obstruction or chronic active hepatitis with or without cirrhosis tended to be positive for succinylated wheat germ agglutinin. Such findings have not been previously reported, to the best of our knowledge. Thus, succinylated wheat germ agglutinin may be a new and useful histochemical tool in routinely processed tissue sections to discriminate intrahepatic vessels into several categories, particularly into two categories (arterial and other vessels), in normal as well as diseased livers.
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PMID:Succinylated wheat germ agglutinin lectin binding in intrahepatic vessels. A new histochemical tool. 834 44

Chylous ascites is mainly due to malignant abdominal disease or cirrhosis. We report the case of chylous ascites associated with protein losing enteropathy caused by fibrotic compression of abdominal lymphatic vessels and superior mesenteric vein complicating alcohol-related chronic pancreatitis. This is the second case published in the literature.
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PMID:[A case of chylous ascites associated with exudative enteropathy complicating chronic pancreatitis of alcoholic origin]. 846 71

Renal sodium and water retention and ascites associated with cirrhosis develop in the setting of severe sinusoidal portal hypertension, hyperdynamic circulation (characterized by arterial hypotension, hypervolaemia, high cardiac output and low peripheral vascular resistance), homeostatic activation of the renin-angiotensin-aldosterone system, sympathetic nervous system and antidiuretic hormone production (i.e. mechanisms designed to maintain arterial pressure within normal limits) and marked increase in hepatic and splanchnic lymph production that overcomes the transport capacity of the lymphatic vessels to the general circulation, leading to leakage of fluid within the peritoneal cavity. Splanchnic arteriolar vasodilation and the increased splanchnic blood flow that characterize portal hypertensive states could be a major factor in the pathogenesis of cirrhotic ascites because it may account for the hyperdynamic circulation, the activation of endogenous neurohormonal systems that cause sodium and water retention and, also, by altering of splanchnic capillary haemodynamics and permeability, the excessive production of lymph in this vascular territory.
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PMID:Mechanism of sodium retention and ascites formation in cirrhosis. 849 67

Patients with cirrhosis of the liver have increased hepatic and gastrointestinal lymph flow that may contribute to the formation of ascites and pleural effusions. Increased lymph flow, which is due to postsinusoidal portal hypertension, causes a high rate of flow through the thoracic duct. Because of the high flow rates, disrupted lymphatic vessels in patients with cirrhosis of the liver may fail to close, a situation that results in chylous ascites, pleural effusions, or chylous fistulas. Chylous fistulas deplete proteins, fluid, and lymphocytes and thus lead to volume depletion and coagulopathy. Herein we describe an unusual case in which a high-output traumatic thoracic duct-cutaneous fistula developed in a patient with cirrhosis and led to volume depletion and coagulopathy. Correction of the portal hypertension with placement of a transjugular intrahepatic portosystemic shunt led to closure of the fistula and normalization of accompanying metabolic abnormalities.
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PMID:Thoracic duct-cutaneous fistula in a patient with cirrhosis of the liver: successful treatment with a transjugular intrahepatic portosystemic shunt. 869 1

A case of a 41-year-old man with diarrhea, hypoalbuminemia, and cryptogenic cirrhosis with features of portal hypertension is described. Protein-losing enteropathy was confirmed by analysis of whole-gut lavage fluid, and intestinal inflammation and infection were excluded. Distal duodenal biopsy specimens showed evidence of edematous villi with prominent submucosal vascular and lymphatic vessels. A transjugular intrahepatic portosystemic stent-shunt was inserted, resulting in resolution of both his diarrhea and elevated whole gut lavage fluid protein concentrations. His symptoms recurred and then again improved after shunt thrombosis and parallel shunt placement, respectively. Histological improvement of the villous edema was also noted. This is the first recorded case of protein-losing enteropathy caused by portal hypertension confirmed by successful treatment with transjugular intrahepatic portosystemic stent-shunt.
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PMID:Transjugular intrahepatic portosystemic shunt as a treatment for protein-losing enteropathy caused by portal hypertension. 894 50

Transcutaneous transhepatic lymphography was conducted in 116 patients with hepatic cirrhosis 127 times in total to study up the type of plasma flow. An inguinal nodulolymphography was performed additionally in several patients. Peripheral type of the plasma flow with the lymphatic vessels net arrangement on periphery of hepar was revealed in 46 patients, the lymphatic ducts blockade on the level of lig. gastroduodenalis, LI-LII vertebral bodies, forming the cisterns--in 24 and without them--in 7 thoracic duct blockade close to its outfall--in 48, and in 11 of them--extended type of the duct outfall. The choice of operative procedure--hepatic extraperitonealization, intraperitoneal and peripheral lymphovenous anastomosis conduction--was accomplished according to the type of the plasma flow present.
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PMID:[The use of x-ray contrast methods in the differential diagnosis of the causes of ascites]. 937 65


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