Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effectiveness of alpha-MPG management was evaluated in terms of changes in the liver cell depuration fraction in patients who presented reduced a levels. There was a marked improvement occasionally to the point of normalisation, in patients with toxic hepatosis. Variations were less significant in cirrhosis, especially in patients with a very low liver metabolism flow. No conclusions could be draw in the case of subjects with chronic heaptitis of various aetiology, since their DF was normal under basal conditions. It seems reasonable to suppose that further improvements are obtainable from prolonged administration of the drug.
 ...
PMID:[Evaluation of the liver cell clearance fraction before and after treatment with alpha-mercaptopropionylglycine in chronic hepatopathies]. 55 Jul 50

The authors studied alcoholic hepatosis and hepatic cirrhosis by laboratory, radioisotope and clinical methods. Most of the routine laboratory techniques, excluding hyperurobilinuria were not very informative in alcoholic hepatosis. Much more frequently it was possible to mark disturbances of the bromsulphaleinic and vofaverdine tests. Of special importance in the evaluation of the acuity and depth of the alcohol intoxication was glutamate and sorbitdehydrogenase. The most informative appeared to be radioisotope hepatography in the phase of alcohol hepatosis and scannography in the formation of liver cirrhosis.
 ...
PMID:[Features of hepatic lesions in patients with chronic alcoholic intoxication]. 126 89

Fatty acid spectrum of liver tissue lipids was studied by means of gas-liquid chromatography in 58 bioptic samples from patients with chronic hepatitis, liver cirrhosis and fatty hepatosis. A statistically significant decrease in content of linoleic, arachidonic and docosahexaenic acids as well as an increase in oleic, palmitoleic and myristic acids were found. Under conditions of the diseases studied fatty acid spectrum of liver tissue lipids altered. A decrease in degree of lipid desaturation was especially distinct in liver tissue cirrhosis.
 ...
PMID:[Fatty acid composition of liver lipids in chronic hepatitis, liver cirrhosis and fatty liver]. 363 12

Necropsy findings of hepatobiliary system from 78 patients with end-stage renal disease maintained on hemodialysis are reported. Ninety percent of the patients exhibited some abnormalities. Multiple abnormalities often coexisted in each patient. Hepatomegaly was found in 50% of the patients and could be attributed to a discernible cause in all but two of the affected patients who had isolated hepatomegaly. Hepatic congestion was also prevalent and was complicated by fibrosis, cardiac cirrhosis, and centrilobular necrosis and hemorrhage in some patients. This was associated with chronic fluid overload, hypertension, and/or cardiovascular disease in the affected patients indicating the importance of adequate control of these factors. Mild periportal hepatic fibrosis, fatty metamorphosis, triaditis, hemosiderosis, and cystic changes were also seen with some frequency--the latter were associated with polycystic kidney disease and were complicated by massive intracystic hemorrhage and abscess formation, each in one patient. Chronic active hepatitis was found in three patients and was associated with chronic HBs antigenemia in one patient and presumed non-A, non-B infection in two. Nearly 22% of the patients showed either cholelithiasis at autopsy or before cholecystectomy due to complications. Significant negative findings included lack of acute viral hepatitis, silicone hepatosis, and recently described focal anoxic lesions associated with erythrocyte sludging. In conclusion, the present study has demonstrated the spectrum of hepatobiliary pathology in a large group of patients with end-stage renal disease maintained on hemodialysis.
 ...
PMID:Hepatobiliary pathology in hemodialysis patients: an autopsy study of 78 cases. 375 41

The authors analyse the possibilities of ultrasonic diagnosis of the diffuse liver diseases. Sixty normal subjects and 114 patients (50 with chronic hepatitis, 30 with hepatosis, 34 liver cirrhosis) were examined. The authors suggest a new method consisting in the measurement of the "compensation power", i. e. of the energy that is consumed during penetration via hepatic tissues with more energy being consumed the denser the tissue. A significant difference in that parameter was recorded between hepatitis, liver cirrhosis and hepatosis, permitting the differentiation between the illnesses under consideration. Study of the other parameters (the length, width, liver log, the diameter of the vena cava inferior, of the splenic vein and spleen) enables expanding the number of indicators used in the diagnosis and differential diagnosis of the liver diseases.
 ...
PMID:[Ultrasonic diagnosis of liver diseases]. 638 4

Experiments were made on male Wistar rats fed the cirrhosogenous diet deficient in protein and choline (group I), protein deficient diet with choline addition (group II), and the animal house diet (group III). Based on histological and electron microscopy studies of rat kidneys and liver made 10 months after the onset of experiments, the group I animals developed glomerulopathy with tubulointerstitial component in the presence of liver fibrosis and cirrhosis. The animals belonging to group II with fatty hepatosis had a similar liver lesion, which was less marked, however. The liver lesion in rats with liver cirrhosis was marked by depositions in the mesangial matrix and in the basal membrane of glomerular capillaries. The severity of the pathological process in the kidneys directly correlated with the morphofunctional status of the liver. Alterations in the liver of the group III animals (with the histological liver structure being normal) were regarded as age-associated.
 ...
PMID:[Morphologic changes in the kidneys in experimental cholino-protein deficiency]. 651 83

Thiopronine has been used to treat 88 patients suffering from chronic hepatitis (65), liver cirrhosis in ascitic phase (14), alcoholic hepatosis(5) and acute hepatitis (4). The drug was employed at the attack stage i.v. at a daily dose of 1-2 grams, and at maintenance phase orally at a dose of 0.750-1 gram. It led to a gradual, significant improvement in clinical symptomatology and hepatofunctional haematochemical indices in all chronic forms, only decompensated cirrhosis showing a slight regression. In hepatic forms, normalisation of subjective and objective parameters was particularly fast, between the 4th and 7th days. Tolerance was very good in 98% of cases.
 ...
PMID:[Therapy of hepatic diseases with alpha-mercaptopropionylglycine]. 707 8

An isolate of Fusarium verticillioides (MRC826) that induced experimental leukoencephalomalacia, also caused acute toxicity when fed to pigs and administered per rumen fistula to sheep. Pigs developed severe pulmonary oedema while sheep manifested severe nephrosis and hepatosis. A less toxic isolate (F. verticillioides MRC602), fed to baboons, resulted in acute congestive heart failure or hepatic cirrhosis, depending on the dose. Both isolates were toxic to rats and caused similar lesions, namely, hepatic cirrhosis and intraventricular cardiac thrombosis.
 ...
PMID:A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. 731 7

The lecture is devoted to the important scientific trends in study of chronic liver diseases (CLD): pathomorphosis, the role of slow viruses and immunity in the pathogenesis. Three main genetically closely interlinked forms of CLD--hepatitis, hepatosis, cirrhosis--are considered. Principal methods of treatment in various forms of CLD are also described. The conclusion about necessity of further exploration of the problem is made.
 ...
PMID:[The clinical picture, diagnosis and treatment of chronic liver diseases (a lecture)]. 820 25

In distinguishing normal from abnormal hepatic changes, the author described the expected changes in liver tests that occur during complicated pregnancy. This article reviews the forms of pre-existing liver disease that may affect or be affected by pregnancy, as well as liver diseases that tend to arise during pregnancy. Among the pre-existing liver diseases are autoimmune chronic active hepatitis, which may be activated by pregnancy and tends to be associated with an increased risk of still and premature births. Worsening of chronic hepatitis B and C has occasionally been observed. While some women with cirrhosis can sustain a normal pregnancy without any worsening of hepatic function, others develop liver failure; plus, women with cirrhosis are less fertile and have higher rates of both stillbirths and premature infants. Other liver disorders that may or may not be affected by pregnancy include Dubin-Johnson syndrome, Gilbert syndrome, benign recurrent intrahepatic cholestasis, Wilson's disease, hepatic adenomas, and focal nodular hyperplasia. Among the hepatic disorders that occur during pregnancy in normally healthy women and then resolve after delivery is intrahepatic cholestasis of pregnancy (also known as pruritus gravidarum, recurrent intrahepatic cholestasis of pregnancy, and obstetric hepatosis). Others include acute fatty liver of pregnancy and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count), which may be part of the spectrum of disorders associated with pre-eclampsia/eclampsia. Pregnancy may also trigger the dissemination of herpes infection to the liver.
 ...
PMID:Liver problems in pregnancy: part 2--managing pre-existing and pregnancy-induced liver disease. 973 96


1 2 Next >>