Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023890 (
cirrhosis
)
42,195
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have examined the expression of c-myc and c-myc promoter binding protein (
MBP-1
), a novel eukaryotic repressor, in human hepatocellular carcinoma and
cirrhosis
by semiquantitative reverse transcription PCR amplification. Levels were normalized for glyceraldehyde-3-phosphate dehydrogenase messenger RNA and then compared between these two groups and to normal liver. We found that
MBP-1
expression was significantly decreased in
cirrhosis
and c-myc and
MBP-1
were even further diminished in hepatocellular carcinoma. There was no clear correlation between
MBP-1
and c-myc messenger RNA levels. Our results therefore suggest that expression of
MBP-1
and c-myc are decreased in a stepwise fashion in the presence of chronic liver disease and hepatocellular carcinoma in humans and that further study of the interactions of these two genes and their products is warranted to determine their role in human hepatocarcinogenesis.
...
PMID:Expression of c-myc promoter binding protein (MBP-1), a novel eukaryotic repressor gene, in cirrhosis and human hepatocellular carcinoma. 1131 33
