Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyponatremic and hepatic encephalopathy are common causes of metabolic encephalopathy that may coexist in patients with cirrhosis. The clinical picture is common to any metabolic encephalopathy and is characterized by a confusional syndrome that may evolve into coma. Chronic mild or minimal manifestations can be seen in both, but motor symptoms are more common in hepatic encephalopathy. Recent advances show that in addition to clinical manifestations both encephalopathies share some pathogenetic mechanisms. Dysfunction of astrocytes, osmotic changes in the brain and brain edema are present in both situations. Recognition of these abnormalities is important to plan therapy. New drugs that affect brain hydration may be useful for both encephalopathies.
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PMID:Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence. 2021 2

Predicting the prognosis of cirrhotic patients is considered to achieve a fair allocation among patients awaiting orthotopic liver transplantation (OLT). Serum sodium (Na) concentrations are associated with reduced survival among patients with cirrhosis. The mortality risk of cirrhotic patients, as defined by the Model for End-Stage Liver Disease (MELD) score, is considered to be higher in hyponatremic patients. The aim of this study was to record complications and outcomes of severely hyponatremic patients after OLT. We retrospectively studied 75 recipients of OLT over the last 3 years. Hyponatremic patients showed lower 30-day and intensive care unit (ICU) survivals (P = .022 and .028, respectively), higher rates of neurological complications (P = .038), renal failure (P = .001), and prolonged duration of mechanical ventilation (P = .000) and ICU stay (P = .000). Severe hyponatremia was related to a greater risk for neurological and renal complications after OLT.
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PMID:The effect of hyponatremia on the outcome of patients after orthotopic liver transplantation. 2314 5