Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 5-year follow-up of 154 male and female patients treated for alcoholism at the Donwood Institute, 22 deaths were recorded--almost 4 times the expected number. Typical causes were accidents, suicide, cirrhosis of the liver, cancers of the upper digestive and respiratory tracts and ischemic heart disease. Compared with other samples of alcoholics, unusually few deaths occurred during the first 2 years of follow-up, which suggests the importance of the post-treatment attention given to these patients and the need to greatly extend the duration of aftercare.
 ...
PMID:Mortality among patients treated for alcoholism: a 5-year follow-up. 16 51

Men drafted into the Army, hospitalized during 1944 to 1945 for service-connected trauma to the extremities, and consequently separated for disability were followed for mortality from January 1946 to April 1977. Three groups were established consisting of those whose injury resulted in (a) limb amputation, (b) disfiguration without loss of body part, (c) loss of part of hand or part of foot. Group (a) had a mortality, standardized for age and calendar time, 1.4 times that of Group (b), matched on age and length of service at admission, and 1.3 times that of Group (c), similar on age and length of service to Group (a). The excess mortality of limb amputees was statistically significant (P less than .05) for ischemic heart disease, other diseases of the cardiovascular system, suicide by poisoning, alcholic cirrhosis, and cute pancreatitis. Possibly (P less than .1) there was also an increased risk of diabetes and cancer of the buccal cavity and pharynx.
 ...
PMID:Report to the Veterans' Administration Department of Medicine and Surgery on service-connected traumatic limb amputations and subsequent mortality from cardiovascular disease and other causes of death. 39 10

The suggested association between high consumption of beer and an increased risk of death from cancer of the colon and rectum was investigated among blue-collar workers at a Dublin brewery, who consume more than average amounts of beer, usually in the form of stout. A study of their mortality between 1954 and 1973 showed that they had as good an expectation of life as all Dublin males, with no increased risk of death from cancer of the oesophagus, pharynx, liver or of cirrhosis of the liver, accidents or suicide, conditions normally associated with the high consumption of alcohol. They had significantly increased risk of death from cancer of the rectum and also from diabetes mellitus. Twenty per cent of the workers, differentiated by their place of work within the brewery, had a much higher risk of death from cancer of the rectum.
 ...
PMID:Causes of death of blue-collar workers at a Dublin brewery, 1954--73. 49 8

Analysis of age-standardized death rates for the main categories of deaths, over the period 1951--1977, shows a three-quarter fall in mortality from infectious diseases, a reduction of mortality from cardiovascular disease more accentuated in women (-46%) than in men (-23%) and a decrease in mortality from tumors in women only (-21%). Suicide rates slightly increased and mortality from accidents started to decrease in 1971, more markedly in men than in women. As regards the last category including all other causes of deaths, a decline in mortality of approximately a half in both sexes was observed. Calculation of the potential years of life lost between ages 1 and 70 (PYLL) reveals that in men, for the year 1977, 25% were due to accidents, 23% to tumours and 22% to cardiovascular diseases, whereas in women tumours came first (36%) and preceded cardiovascular disease (17%). Analysis of PYLL by individual cause of death shows, in decreasing order of importance, for men: motor accidents, suicide, ischaemic heart disease, other accidents, cancer of lung, cerebrovascular disease and cirrhosis of liver, and for women: suicide, breast cancer, motor accidents, other accidents, cerebrovascular disease, ischaemic heart disease and uterine cancer. Finally, life expectancy at birth increased, over the period 1951--1977, from 66.4 to 71.8 years in men and from 71.0 to 78.4 years in women, which ranks Switzerland third among the 10 industrialized countries studies.
 ...
PMID:[Mortality trends in Switzerland 1951-1977. Principal categories of the causes of death]. 51 12

From 1951 to 1971 male doctors reduced their cigarette smoking more than did men in social classes I and II combined. In 1970-2, 665 male doctors died aged under 65. Had they shown the same improvements in cause-specific death rates over the 20 years as men in classes I and II, 699 deaths would have been expected. This "saving" of 34 deaths in the doctors comprised savings from coronary heart disease (83), stroke (16), and lung cancer (8) balanced by 60 "losses" from three stress-related causes--namely, accident, poisonings, etc (30); suicide (26); and cirrhosis of the liver (4)--plus 13 from other causes. As a relative reduction in mortality from heart disease in doctors (as compared with that in social classes I and II) also occurred during 1931-51--that is, before they began to give up smoking--some of the saving in heart-disease deaths in 1951-71 was probably not related to changes in smoking habits. The relative worsening in mortality from stress-related diseases may have been due partly to a possible adverse effect of giving up smoking if smoking had acted to reduce stress. From these findings, the benefits of giving up smoking may not be so great as has commonly been assumed.
 ...
PMID:Has the mortality of male doctors improved with the reductions in their cigarette smoking? 53 59

This is a study of alcoholic mortality in which time, cause, and age at death were variables of critical interest. Five cohorts of 100 members each were followed 12, 11, 9, 6, and 4 years. A total of 133 cases were located as deceased. The overall case fatality rate (CFR) was .0371. Higher CFR's were observed in years 1 to 6. Cardiovascular disease, violence (homicide, suicide, accidental), cirrhosis, carcionomas, and acute intoxication were the leading causes of death. Violent deaths were more prevalent in younger admission age groups. The cardiovascular/other ratio increased in older admission age groups.
 ...
PMID:Alcoholic mortality: a 12-year follow-up. 74 74

The general death rate rises during business booms and falls during depressions. The causes of death involved in this variation range from infectious diseases through accidents to heart disease, cancer, and cirrhosis of the liver, and include the great majority of all causes of death. Less than 2 percent of the death rate-that for suicide and homicide-varies directly with unemployment. In the older historical data, deterioration of housing and rise of alcohol consumption on the boom may account for part of this variation. In twentieth-century cycles, the role of social stress is probably predominant. Overwork and fragmentation of community through migration are two important sources of stress which rise with the boom, and they are demonstrably related to the causes of death which show this variation.
 ...
PMID:Prosperity as a cause of death. 83 36

An analysis has been made of 235 deaths that occurred among 1905 patients with peptic ulcer who constituted a random sample of the occurrence of ulcer disease in an area of Denmark comprising half a million inhabitants. The disease itself, according to the death certificate, was considered the primary cause of death in 10% of the cases; half of these had been operated on immediately before death. The other patients died more frequently than expected from the following causes: chronic bronchitis, pulmonary emphysema, cancer of the lung, cirrhosis of the liver, and cancer of the pancreas. Although the comorbidity with chronic bronchitis and emphysema was especially pronounced in patients with gastric ulcer, the association with liver cirrhosis and cancer of the pancreas occurred only in patients with duodenal ulcer. In women the mortality rate attributable to cardiac and vascular diseases was lower than expected. No excess coincidence of suicide was found. Berkson's fallacy is considered to be of much less importance as a possible explanation of the comorbidity found in the present study than in the majority of publications concerned with this question.
 ...
PMID:Causes of death in duodenal and gastric ulcer. 90 79

In the contemporary United States, mortality is 60% higher for males than for females. Forty percent of the excess of male mortality is due to arteriosclerotic heart disease, which is more common among men in part because they smoke cigarettes more than women do, and apparently also because they more often develop the competitive, aggressive Coronary Prone Behavior Pattern. Men who do not develop this Behavior Pattern may have as low a risk of coronary heart disease as comparable women. Oophorectomy of young women may increase the risk of coronary heart disease, but administration of female hormones generally does not reduce risk. One third of the sex differential in mortality is due to men's higher rates of suicide, fatal motor vehicle and other accidents, cirrhosis of the liver, respiratory cancers and emphysema. Each of these causes of death is linked to behaviours which are encouraged or accepted more in males than in females: using guns, drinking alcohol, smoking, working at hazardous jobs, and seeming to be fearless. Thus, the behaviors expected of males in our society make a major contribution to their elevated mortality.
 ...
PMID:Why do women liver longer than men? 101 12

In the contemporary United States, males have 60 percent higher mortality than females. In Part I, published in the previous issue, we showed that 40 percent of this sex differential in mortality is due to a twofold elevation of arteriosclerotic heart disease among men. Major causes of higher rates of arteriosclerotic heart disease in men include greater cigarette smoking among men; probably a greater prevalence of the competitive, aggressive Coronary Prone Behavior Pattern among men; and possibly a protective role of female hormones. In addition, men have higher death rates for lung cancer and emphysema, primarily because more men smoke cigarettes. In Part II we analyze the other major causes of men's higher death rates: accidents, suicide, and cirrhosis of the liver. Each of these is related to behaviors which are encouraged or accepted more in men than in women in our society--for example, using guns, being adventurous and acting unafraid, working at hazardous jobs and drinking alcohol. We conclude with suggestions for reducing male mortality; for example, by changing the social conditions which foster in men the behaviors that elevate their mortality.
 ...
PMID:Why do women live longer than men? 101 15


1 2 3 4 5 6 7 8 9 10 Next >>