Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023890 (
cirrhosis
)
42,195
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gastrointestinal failure
(
GIF
) is frequent in patients managed in the intensive care units and manifests as gut paralysis or ileus.
GIF
is often associated with sepsis or multiorgan failure. In critically ill patients, the precipitating causes of
GIF
include inflammation, sepsis, electrolyte abnormalities, and acidosis. It is possible that
GIF
is associated with an increase in bacterial translocation, especially in those with
cirrhosis
and portal hypertension, and this may play a significant pathogenic or prognostic role in acute-on-chronic liver failure (ACLF). The critical care literature suggests that
GIF
is associated with a higher mortality risk. In this review, we summarize the evidence for a potential association between
GIF
and ACLF and propose treatment options for the management of
GIF
. Moreover, we suggest
GIF
to be considered as another organ failure when the severity of ACLF is assessed.
...
PMID:Gastrointestinal Failure in Critically Ill Patients With Cirrhosis. 3118 4
